Disodium terephthalate (Synonyms: Terephthalic acid disodium salt)

Cat. No.: HY-W250127 Purity: 99.93%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Disodium terephthalate (Terephthalic acid disodium salt) is an isomer and a precursor of polyester PET, which can be used to make clothing and plastics. Disodium terephthalate can be used to build skin tumor models.

For research use only. We do not sell to patients.

Disodium terephthalate Chemical Structure

CAS No. : 10028-70-3

Size	Stock	Quantity
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	Get quote	Estimated Time of Arrival: December 31
25 g	Get quote	Estimated Time of Arrival: December 31
50 g	Get quote	Estimated Time of Arrival: December 31
> 100 g	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of Disodium terephthalate:

Terephthalic acid In-stock

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Disodium Terephthalate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Terephthalic acid can be used in animal modeling to create skin tumor models. In experiments, Terephthalic acid is administered orally to weanling and adult mice, exhibiting distinct pharmacokinetic features. Terephthalic acid is metabolized in the body to form calcium terephthalate or calcium hydrogen terephthalate, leading to oversaturation in the urine and promoting the formation of bladder stones. The lithogenic effect of Terephthalic acid is more pronounced in weanling mice than in adults, and its effect on bladder stone formation is more significant at higher doses (1000 mg/kg/day), with no noticeable effects observed at a dose of 142 mg/kg/day. The safe dosage range for Terephthalic acid in terms of inducing lithogenesis is: oral administration not exceeding 0.5 mg/kg/day, and a total concentration in drinking water not exceeding 3 mg/L.

Induction of skin tumor^[2]

Background

Terephthalic acid can promote excessive cell proliferation and induce skin tumor formation by disrupting the p16-cyclin D1/Cdk4-Rb cell cycle regulatory pathway^[3].

Specific Modeling Methods

Mice: C57BL/6• male and female • 8-10 weeks old
Administration: 10 μg/mouse • topical application • refer to the note for details on the administration method

Note

(1) The K14Cre^ER-Cenp-50/U^fl/fl mice used in the experiment are for conditional knockout of Cenp-50/U and are on a C57BL/6 background.
(2) DMBA and Terephthalic acid combined administration: Shave the backs of 8-10 week old mice, first apply DMBA (HY-W011845) (25 μg per mouse, dissolved in 200 μL of acetone) to the shaved dorsal skin, then apply Terephthalic acid (10 μg per mouse, dissolved in 200 μL of acetone) on the 3rd day after the first DMBA treatment.
(3) After 4 rounds of the above DMBA and Terephthalic acid combined treatment, mice receive Terephthalic acid (10 μg per mouse, dissolved in 200 μL of acetone) alone twice weekly for 20 weeks.

Modeling Indicators

Phenotypic Observations: Skin tumors in mice, including papillomas and carcinomas.

Correlated Product(s): DMBA (HY-W011845)

Opposite Product(s): /

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

210.09

Formula

C₈H₄Na₂O₄

CAS No.

10028-70-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C(O[Na])=O)C=C1)O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 70 mg/mL (333.19 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7599 mL	23.7993 mL	47.5986 mL
5 mM	0.9520 mL	4.7599 mL	9.5197 mL
10 mM	0.4760 mL	2.3799 mL	4.7599 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.93%

Select Batch:

Data Sheet (277 KB) SDS (480 KB)

COA (247 KB) HNMR (224 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. Heck HD, et al. The induction of bladder stones by terephthalic acid, dimethyl terephthalate, and melamine (2,4,6-triamino-s-triazine) and its relevance to risk assessment. Regul Toxicol Pharmacol. 1985 Sep;5(3):294-313. [Content Brief]

[2]. Saito M, et al. CENP-50 is required for papilloma development in the two-stage skin carcinogenesis model. Cancer Sci. 2020 Aug;111(8):2850-2860. [Content Brief]

[3]. Cui L, et al. Deregulation of the p16-cyclin D1/cyclin-dependent kinase 4-retinoblastoma pathway involved in the rat bladder carcinogenesis induced by terephthalic acid-calculi. Urol Res. 2006 Oct;34(5):321-8. [Content Brief]

[4]. Ball GL, et al. Toxicological review and oral risk assessment of terephthalic acid (TPA) and its esters: A category approach. Crit Rev Toxicol. 2012 Jan;42(1):28-67. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.7599 mL	23.7993 mL	47.5986 mL	118.9966 mL
	5 mM	0.9520 mL	4.7599 mL	9.5197 mL	23.7993 mL
	10 mM	0.4760 mL	2.3799 mL	4.7599 mL	11.8997 mL
	15 mM	0.3173 mL	1.5866 mL	3.1732 mL	7.9331 mL
	20 mM	0.2380 mL	1.1900 mL	2.3799 mL	5.9498 mL
	25 mM	0.1904 mL	0.9520 mL	1.9039 mL	4.7599 mL
	30 mM	0.1587 mL	0.7933 mL	1.5866 mL	3.9666 mL
	40 mM	0.1190 mL	0.5950 mL	1.1900 mL	2.9749 mL
	50 mM	0.0952 mL	0.4760 mL	0.9520 mL	2.3799 mL
	60 mM	0.0793 mL	0.3967 mL	0.7933 mL	1.9833 mL
	80 mM	0.0595 mL	0.2975 mL	0.5950 mL	1.4875 mL
	100 mM	0.0476 mL	0.2380 mL	0.4760 mL	1.1900 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Disodium terephthalate Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Disodium terephthalate10028-70-3Terephthalic acid disodiumBiochemical Assay Reagentsbiochemical assayreagentInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Disodium terephthalate (Synonyms: Terephthalic acid disodium salt)

Other Forms of Disodium terephthalate:

Disodium terephthalate Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Disodium terephthalate Related Antibodies

Molarity Calculator

Dilution Calculator