2. Anti-infection Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation NF-κB Neuronal Signaling Membrane Transporter/Ion Channel MAPK/ERK Pathway
  3. HIV HIV Protease Apoptosis Reactive Oxygen Species Calcium Channel NO Synthase Interleukin Related Toll-like Receptor (TLR) p38 MAPK JNK
  4. Saquinavir mesylate

Saquinavir mesylate  (Synonyms: Ro 31-8959/003)

Cat. No.: HY-17003 Purity: 99.84%
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Saquinavir (Ro 31-8959) mesylate is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir mesylate also has anti-inflammatory activity and can induce apoptosis of human red blood cells.

For research use only. We do not sell to patients.

Saquinavir mesylate Chemical Structure

Saquinavir mesylate Chemical Structure

CAS No. : 149845-06-7

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10 mM * 1 mL in DMSO
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Based on 13 publication(s) in Google Scholar

Other Forms of Saquinavir mesylate:

Saquinavir mesylate Related Antibodies

Top Publications Citing Use of Products

    Saquinavir mesylate purchased from MedChemExpress. Usage Cited in: Antiviral Res. 2022 Nov 10;105463.  [Abstract]

    Saquinavir (1, 5, 10, 20 µM; 24 h) inhibits the autophagy in U87 cells, and the expression of p62 is increased in a concentrationdependent manner.

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    IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Saquinavir (Ro 31-8959) mesylate is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir mesylate also has anti-inflammatory activity and can induce apoptosis of human red blood cells[1][2][3].

    Cellular Effect
    Cell Line Type Value Description References
    MT4 ED50
    0.006 μM
    Compound: Ro-318959 (Saquinavir mesylate)
    Concentration that inhibits cellular growth of MT-4 cells acutely infected with HIV-1 RFstrain by 50%
    Concentration that inhibits cellular growth of MT-4 cells acutely infected with HIV-1 RFstrain by 50%
    		10.1016/S0960-894X(01)80332-2
    In Vitro

    Saquinavir (2.5-15 μg/mL; 48 h) mesylate can induce the apoptosis of human red blood cells, and the mechanism involves the generation of ROS and the influx of Ca2+[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Saquinavir mesylate Related Antibodies
    In Vivo

    Saquinavir (250-2500 mg/kg; administered via diet; 1 month) mesylate exhibits anti-HIV activity in the thy/liv-SCID-hu mouse model[2].
    Saquinavir (0.5 mg/kg; twice) mesylate has a protective effect in the mouse model of lung injury induced by hepatic ischemia-reperfusion (I/R)[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Human thymic and liver tissues (hu-thy/liv) were implanted under both kidney capsules in SCID mice (thy/liv-SCID-hu mice)[2]
    Dosage: 250 or 2500 mg/kg
    Administration: Via diet for 1 month
    Result: Significantly reduced the viral load in the implanted hu-thy/liv and spleens of HIV-infected thy/liv-SCID-hu mice in a dose-related manner.
    Animal Model: C57BL/6 mice aged 8-12 weeks old with hepatic I/R injury model[3]
    Dosage: 0.5 mg/kg
    Administration: Pretreated 1 h before ischemia and again at the time of reperfusion
    Result: Markedly attenuated remote lung tissue injury.
    Attenuated I/R-induced lung edema, hyperpermeability, and pathological injury.
    Decreased levels of circulating and lung tissue inflammatory cytokines, such as IL-6, IL-1β, TNF-α, and iNOS.
    Decreased lung tissue expression of HMGB1, TLR-4, and p-P38/JNK, but not p-ERK.
    Clinical Trial
    Molecular Weight

    766.95

    Formula

    C39H54N6O8S
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CS(=O)(O)=O.O=C(C1=NC2=C(C=CC=C2)C=C1)N[C@@H](CC(N)=O)C(N[C@@H](CC3=CC=CC=C3)[C@H](O)CN4[C@@H](C[C@@]5([H])[C@@](CCCC5)([H])C4)C(NC(C)(C)C)=O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 16.67 mg/mL (21.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3039 mL 6.5193 mL 13.0387 mL
    5 mM 0.2608 mL 1.3039 mL 2.6077 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Volume
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    C2

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2 mg/mL (2.61 mM); Clear solution

      This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2 mg/mL (2.61 mM); Clear solution

      This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.3039 mL 6.5193 mL 13.0387 mL 32.5966 mL
    5 mM 0.2608 mL 1.3039 mL 2.6077 mL 6.5193 mL
    10 mM 0.1304 mL 0.6519 mL 1.3039 mL 3.2597 mL
    15 mM 0.0869 mL 0.4346 mL 0.8692 mL 2.1731 mL
    20 mM 0.0652 mL 0.3260 mL 0.6519 mL 1.6298 mL
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    Saquinavir mesylate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Saquinavir149845-06-7Ro 31-8959/003HIVHIV ProteaseApoptosisReactive Oxygen SpeciesCalcium ChannelNO SynthaseInterleukin RelatedToll-like Receptor (TLR)p38 MAPKJNKHuman immunodeficiency virusCa2+ channelsCa channelsNitric oxide synthasesNOSILc-Jun N-terminal kinaseI/R injury modelHIV modelred blood cellsInhibitorinhibitorinhibit

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