2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. P-gp-IN-30

P-gp-IN-30 (Compound 13) is a P-glycoprotein (P-gp) inhibitor by targeting YB-1. P-gp-IN-30 significantly enhances sensitivity to Paclitaxel by reducing total YB-1 and nucleus YB-1 protein expression, inhibiting the expression and function of downstream P-gp, further suppressing the efflux rate of Paclitaxel. P-gp-IN-30 potently inhibits tumor growth in A549/Taxol xenografts mice model with combination of Paclitaxel (HY-B0015). P-gp-IN-30 can be used for non-small cell lung cancer (NSCLC) research.

For research use only. We do not sell to patients.

P-gp-IN-30

P-gp-IN-30 Chemical Structure

CAS No. : 2761881-65-4

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P-gp-IN-30 Related Antibodies

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Description

P-gp-IN-30 (Compound 13) is a P-glycoprotein (P-gp) inhibitor by targeting YB-1. P-gp-IN-30 significantly enhances sensitivity to Paclitaxel by reducing total YB-1 and nucleus YB-1 protein expression, inhibiting the expression and function of downstream P-gp, further suppressing the efflux rate of Paclitaxel. P-gp-IN-30 potently inhibits tumor growth in A549/Taxol xenografts mice model with combination of Paclitaxel (HY-B0015). P-gp-IN-30 can be used for non-small cell lung cancer (NSCLC) research[1].

Molecular Weight

616.66

Formula

C34H36N2O9
CAS No.
SMILES

CCOC(C1([C@]2(C3=CC=CC=C3NC2=O)[C@H](C4=CC=CC=C4)[C@@H](C5=CC[C@@]6([H])[C@]5([H])[C@H](OC)OC=C6C(OC)=O)N1)C(OCC)=O)=O
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P-gp-IN-30 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P-gp-IN-302761881-65-4P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243InhibitorsYB-1PaclitaxelA549/Taxol xenografts mice modelNon-small cell lung cancerNSCLCInhibitorinhibitorinhibit

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HY-175206
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