2. Anti-infection
  3. HCV
  4. Ruzasvir

Ruzasvir (MK-8408) is an orally active inhibitor for genotypic HCV nonstructural protein 5A (NS5A), which inhibits the replication of NS5A mutants GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a and GT4a with EC90 ranging from 0.003 to 0.067 nM. Ruzasvir exhibits good pharmacokinetic characters in rhesus monkey model.

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Ruzasvir Chemical Structure

Ruzasvir Chemical Structure

CAS No. : 1613081-64-3

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Based on 1 publication(s) in Google Scholar

Ruzasvir Related Antibodies

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Description

Ruzasvir (MK-8408) is an orally active inhibitor for genotypic HCV nonstructural protein 5A (NS5A), which inhibits the replication of NS5A mutants GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a and GT4a with EC90 ranging from 0.003 to 0.067 nM. Ruzasvir exhibits good pharmacokinetic characters in rhesus monkey model[1].

Molecular Weight

947.09

Formula

C49H55FN10O7S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

FC1=C2C3=CC4=CC(C5=CN=C([C@H](CCC6)N6C([C@H](C(C)C)NC(OC)=O)=O)N5)=CC=C4N3[C@H](C7=CN=C(C8CC8)S7)OC2=CC(C9=CN=C([C@H](CCC%10)N%10C([C@H](C(C)C)NC(OC)=O)=O)N9)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (105.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0559 mL 5.2793 mL 10.5587 mL
5 mM 0.2112 mL 1.0559 mL 2.1117 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0559 mL 5.2793 mL 10.5587 mL 26.3966 mL
5 mM 0.2112 mL 1.0559 mL 2.1117 mL 5.2793 mL
10 mM 0.1056 mL 0.5279 mL 1.0559 mL 2.6397 mL
15 mM 0.0704 mL 0.3520 mL 0.7039 mL 1.7598 mL
20 mM 0.0528 mL 0.2640 mL 0.5279 mL 1.3198 mL
25 mM 0.0422 mL 0.2112 mL 0.4223 mL 1.0559 mL
30 mM 0.0352 mL 0.1760 mL 0.3520 mL 0.8799 mL
40 mM 0.0264 mL 0.1320 mL 0.2640 mL 0.6599 mL
50 mM 0.0211 mL 0.1056 mL 0.2112 mL 0.5279 mL
60 mM 0.0176 mL 0.0880 mL 0.1760 mL 0.4399 mL
80 mM 0.0132 mL 0.0660 mL 0.1320 mL 0.3300 mL
100 mM 0.0106 mL 0.0528 mL 0.1056 mL 0.2640 mL
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Ruzasvir Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ruzasvir1613081-64-3MK-8408MK8408MK 8408HCVHepatitis C virusorally activerhesus monkeyInhibitorinhibitorinhibit

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