2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Sec61

Sec61

Sec61 complex, SecY, Sec61 channel

Sec61 is a heterotrimeric protein complex located on the endoplasmic reticulum membrane and belongs to the protein transporter family. Sec61 is mainly composed of Sec61α, Sec61β and Sec61γ. Sec61 is closely associated with signal recognition particles (SRP), SRP receptors, BiP, Sec62/Sec63 complex, TRAP, OST, etc. The main function of Sec61 is to assist the entry of nascent polypeptides into the endoplasmic reticulum during protein translation, participate in the transmembrane transport, membrane insertion and folding modification of proteins, and also play a role in the regulation of calcium ion homeostasis, as an endoplasmic reticulum calcium ion leakage channel to affect intracellular calcium signals. Specific Sec61 mutations can disrupt endoplasmic reticulum calcium balance and induce pancreatic β-cell apoptosis. Sec61 mutations interfere with the normal function of B cells. Abnormal expression of Sec61 is closely related to cell proliferation, invasion and drug resistance. Sec61 is closely related to a variety of diseases, including diabetes, immunodeficiency diseases (such as common variable immunodeficiency disease), kidney diseases (such as tubulointerstitial disease), and cancer. [1][2][3][4][5][6].

Sec61 Related Products (2):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-139615
    Sec61-IN-1
    		Inhibitor 99.70%
    Sec61-IN-1 (compound A317) is a potent sec61 inhibitor that effectively targets glioma cells and enhances T cell cytotoxic effects[1][2].
    Sec61-IN-1
  • HY-176763
    KZR-261
    		Inhibitor
    KZR-261 is a Sec61 inhibitor. KZR-261 directly binds to the Sec61 channel to potently inhibit the biogenesis of a subset of Sec61 client proteins. KZR-261 has a broad antitumor activity (such as colorectal pancreas and prostate cancer), along with the activation of an endoplasmic reticulum stress response, with minimal adverse effects on normal cells. KZR-261 significantly induces apoptosis of H929 cells. KZR-261 potently inhibits tumor growth in multiple xenograft tumor mice models with good tolerance.
    KZR-261