2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Sec61
  5. Sec61 Inhibitor

Sec61 Inhibitor

Sec61 Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-139615
    Sec61-IN-1
    		Inhibitor 99.70%
    Sec61-IN-1 (compound A317) is a potent sec61 inhibitor that effectively targets glioma cells and enhances T cell cytotoxic effects[1][2].
  • HY-176763
    KZR-261
    		Inhibitor
    KZR-261 is a Sec61 inhibitor. KZR-261 directly binds to the Sec61 channel to potently inhibit the biogenesis of a subset of Sec61 client proteins. KZR-261 has a broad antitumor activity (such as colorectal pancreas and prostate cancer), along with the activation of an endoplasmic reticulum stress response, with minimal adverse effects on normal cells. KZR-261 significantly induces apoptosis of H929 cells. KZR-261 potently inhibits tumor growth in multiple xenograft tumor mice models with good tolerance.