2. Immunology/Inflammation
  3. BCL6
  4. BCL6-760

BCL6-760 is an orally active BCL-6 PROTAC degrader with an EC50 of 0.8 nM. BCL6-760 only degrades BCL6 and has no effect on other CRBN substrates. BCL6-760 demonstrates significant efficacy in the orthotopic xenograft mouse model of OCI-LY-1 tumors. BCL6-760 can be used in the research of diffuse Large B-cell Lymphoma (DLBCL) (Pink: BCL-6 ligand (HY-179317); Blue: CRBN ligand (HY-179305); Black: Linker).

For research use only. We do not sell to patients.

BCL6-760

BCL6-760 Chemical Structure

CAS No. : 3084696-50-1

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BCL6-760 Related Antibodies

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Description

BCL6-760 is an orally active BCL-6 PROTAC degrader with an EC50 of 0.8 nM. BCL6-760 only degrades BCL6 and has no effect on other CRBN substrates. BCL6-760 demonstrates significant efficacy in the orthotopic xenograft mouse model of OCI-LY-1 tumors. BCL6-760 can be used in the research of diffuse Large B-cell Lymphoma (DLBCL) (Pink: BCL-6 ligand (HY-179317); Blue: CRBN ligand (HY-179305); Black: Linker)[1].

In Vitro

BCL6-760 inhibits OCI-LY-1 cells growth with a GI50 of 1.3 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BCL6-760 Related Antibodies
In Vivo

BCL6-760 (15-60 mg/kg, p.o., once or twice daily for 5 days) effectively and continuously degrades the BCL6 protein in tumors, and produces significant anti-tumor effects in OCI-LY-1 tumor xenograft mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

715.24

Formula

C36H43ClN10O4
CAS No.
SMILES

CN(C1=NC(NC2=CC=C3N(C(N(C3=C2)CCC(C)(O)C)=O)C)=C(C=N1)Cl)C4CCN(C5=CC6=C(C(C7CCC(NC7=O)=O)=NN6C)C=C5)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BCL6-760 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BCL6-7603084696-50-1BCL6B-cell lymphoma 6 proteinB-cell lymphoma 5 protein (BCL-5)Zinc finger and BTB domain-containing protein 27Zinc finger protein 51English ExplanationProteolysis-Targeting ChimeraStructure-Activity RelationshipInhibitorinhibitorinhibit

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