2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse CD96 Antibody (3.3)

Anti-Mouse CD96 Antibody (3.3) 

Cat. No.: HY-P990259 Purity: 95.00%
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Anti-Mouse CD96 Antibody (3.3) is a rat-derived anti-mouse CD96 IgG1 λ type antibody inhibitor. Anti-Mouse CD96 Antibody (3.3) blocks binding of CD155 to CD96. Anti-Mouse CD96 Antibody (3.3) can enhance the antitumor efficacy of multiple immune-checkpoint inhibitors. Anti-Mouse CD96 Antibody (3.3) shows potent anti-tumor and anti-metastatic activity in various tumor models. Anti-Mouse CD96 Antibody (3.3) can be used for the researches of cancer and inflammation, such as mammary carcinoma.

For research use only. We do not sell to patients.

Anti-Mouse CD96 Antibody (3.3) Chemical Structure

Anti-Mouse CD96 Antibody (3.3) Chemical Structure

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Description

Anti-Mouse CD96 Antibody (3.3) is a rat-derived anti-mouse CD96 IgG1 λ type antibody inhibitor. Anti-Mouse CD96 Antibody (3.3) blocks binding of CD155 to CD96. Anti-Mouse CD96 Antibody (3.3) can enhance the antitumor efficacy of multiple immune-checkpoint inhibitors. Anti-Mouse CD96 Antibody (3.3) shows potent anti-tumor and anti-metastatic activity in various tumor models. Anti-Mouse CD96 Antibody (3.3) can be used for the researches of cancer and inflammation, such as mammary carcinoma[1][2][3][4].

IC50 & Target

CD96
In Vitro

Anti-Mouse CD96 Antibody (3.3) (0.0001-100 μg/mL, 48 h) dependently decreases binding of CD155 to CD96 in HEK-293 cells[1].
Anti-Mouse CD96 Antibody (3.3) (24 h) enhances PD-1 blockade to unleash CD8+ tumor infiltrating lymphocytes function in tumor single cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD96 Antibody (3.3) Related Antibodies
In Vivo

Anti-Mouse CD96 Antibody (3.3) (250-400 μg, i.p., for 2 times) shows significant anti-metastatic activity in B16F10 experimental metastases and orthotopic 4T1.2 mammary carcinoma mice models[1].
Anti-Mouse CD96 Antibody (3.3) (250 μg, i.p., for 4 times) shows potent anti-tumor effect in B16F10/CT26/MCA1956 tumor models[2].
Anti-Mouse CD96 Antibody (3.3) (200 μg, i.p., 2 times a week) significantly delays tumor growth and prolongs the survival in TC-1 tumor-bearing mice models[3].
Anti-Mouse CD96 Antibody (3.3) (250 μg, i.p.) restores inflammatory properties in Th9 cells in allogeneic skin transplantation CD96high mice models[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16F10 experimental metastases mice models[1]
Dosage: 250 μg
Administration: Intraperitoneally injection, at day 0, 3
Result: Had significant anti-metastatic activity.
Mediated metastases suppression via NK cells and IFN-γ.
Animal Model: Orthotopic 4T1.2 mammary carcinoma mice models[1]
Dosage: 400 μg
Administration: Intraperitoneally injection, at day 12, 14
Result: Displayed significant anti-metastatic activity.
Animal Model: B16F10/CT26/MCA1956 tumor models[2]
Dosage: 250 μg
Administration: Intraperitoneally injection, for 4 times
Result: Suppressed tumor growth
Enhanced the antitumor efficacy of multiple immune-checkpoint inhibitors.
Animal Model: TC-1 tumor-bearing C57BL/6 mice models[3]
Dosage: 200 μg
Administration: Intraperitoneally injection, 2 times a week
Result: Significantly delayed tumor growth and prolonged the survival.
Animal Model: Allogeneic skin transplantation CD96high mice models[4]
Dosage: 250 μg
Administration: Intraperitoneally injection
Result: Enhanced skin graft inflammation.
Displayed more severe destruction and T-cell infiltration.
Significantly increased T-cell numbers in draining and mesenteric lymph nodes and in the spleen.
Gene ID

84544  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD96 Antibody (3.3)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse CD96 Antibody (3.3) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD96 Antibody (3.3)Transmembrane GlycoproteinCD96CD155CancerInflammationMammary carcinoma4T1 cellsB16F10 cellsCT26 cellsMCA1956 cellsInhibitorinhibitorinhibit

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