2. GPCR/G Protein
  3. Free Fatty Acid Receptor
  4. CPL207280

CPL207280 is an orally active GPR40/FFA1 agonist with an antidiabetic effect. CPL207280 can effectively enhance glucose-stimulated insulin secretion and improve glucose tolerance in MIN6 pancreatic β-cells as well as in healthy Wistar Han rats and diabetic rat models. CPL207280 can be used for the research of type 2 diabetes.

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CPL207280 Chemical Structure

CPL207280 Chemical Structure

CAS No. : 2361497-72-3

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CPL207280 Related Antibodies

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Description

CPL207280 is an orally active GPR40/FFA1 agonist with an antidiabetic effect. CPL207280 can effectively enhance glucose-stimulated insulin secretion and improve glucose tolerance in MIN6 pancreatic β-cells as well as in healthy Wistar Han rats and diabetic rat models. CPL207280 can be used for the research of type 2 diabetes[1][2].

In Vivo

PL207280 (10 mg/kg; p.o.; single dose) exhibits hypoglycemic effects in Wistar Han rats, with (3 mg/kg; p.o.; single dose) pharmacokinetic parameters of Cmax, Tmax, and T1/2 being 1699 ng/mL, 1 h, and 1.41 h, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

286.37

Formula

C18H22O3
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

OC(C[C@@H](C1=CC=C(C=C1)OC/C(C)=C(C)/C)C#CC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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CPL207280 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CPL2072802361497-72-3CPL 207280CPL-207280Free Fatty Acid ReceptorFFARdiabetesWistar Han rats， GK rats、ZDSD rats、ZDF ratsMIN6 pancreatic β-cellsInhibitorinhibitorinhibit

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