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In (Lu)-related protein p80

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AIM2 (2) Atg4 (1) Atg8/LC3 (5) ATM/ATR (28) Interleukin Related (103) Kallikrein (8) Mas-related G-protein-coupled Receptor (MRGPR) (2) NEKs (8) Oxysterol-binding Protein-related Protein (ORP) (1) ROR (9) RUNX (2) Trk Receptor (49) 11β-HSD (14) 15-PGDH (3) 17β-HSD (117) 3β-HSD (1) 5 alpha Reductase (3) 5-HT Receptor (11) AAK1 (16) Acetyl-CoA Carboxylase (6) Acetyl-CoA synthetase (1) Ack1 (1) Acyltransferase (31) ADAMTS (3) ADC Payload (6) Adenosine Deaminase (1) Adenosine Kinase (1) Adenosine Receptor (4) Adenylate Cyclase (4) Adrenergic Receptor (7) Akt (97) Aldehyde Dehydrogenase (ALDH) (13) Aldose Reductase (33) Amine N-methyltransferase (5) Amino Acid Oxidase (2) Amino acid Transporter (2) Aminoacyl-tRNA Synthetase (13) Aminopeptidase (12) Aminotransferases (Transaminases) (4) AMPK (22) Amylases (38) Amyloid-β (76) Anaplastic lymphoma kinase (ALK) (37) Androgen Receptor (11) Angiotensin Receptor (1) Angiotensin-converting Enzyme (ACE) (5) Antibiotic (33) Antifolate (3) 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YAP (31) YB-1 (1) YTHDF (2) α-synuclein (6) β-catenin (24) β-glucuronidase (5) γ-Glutamyl Transferase (GGT) (2) γ-secretase (10)
By Research Areas:	Cancer (4392) Cardiovascular Disease (256) Endocrinology (44) Infection (1284) Inflammation/Immunology (1257) Metabolic Disease (652) Neurological Disease (938)
Click Chemistry:	Azide (25) Alkynes (39)
Oligonucleotides:	Fluorescent Lipids (1) Pegylated Lipids (1) Fillers (1) Rat Pre-designed siRNA Sets (3) Cationic Lipids (4) Solubilizing Agents (1) Binders (1) Antisense Oligonucleotides (1) siRNAs (3)

8333

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

CaMKIIα-IN-1	CaMK	Neurological Disease
CaMKIIα-IN-1 (Compound 4d) is an orally active Ca ²⁺/calmodulin-dependent protein kinase II α (CaMKIIα) inhibitor with a K_D of 219 nM for CaMKIIα WT hub. CaMKIIα-IN-1 has good metabolic stability .

5-LO/mPGES1-IN-1	Lipoxygenase PGE synthase	Inflammation/Immunology
5-LO/mPGES1-IN-1 (Compound 16) is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO). IC₅₀ values are 0.3 and 0.4 μM, respectively. 5-LO/mPGES1-IN-1 has anti-inflammatory activity .

DPP-4-IN-9	Dipeptidyl Peptidase	Metabolic Disease
DPP-4-IN-9 (compound 6l) is a potent inhibitor of dipeptidyl peptidase DPP-4 (IC₅₀: 8.22 nM). DPP-4-IN-9 has antihyperglycemic activity .

α-Amylase/α-Glucosidase-IN-4	Glycosidase Amylases	Metabolic Disease
α-Amylase/α-Glucosidase-IN-4 (compound 5) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC₅₀s of 0.15 μM and 1.10 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity .

PfDHODH-IN-3	Parasite Dihydroorotate Dehydrogenase	Infection
PfDHODH-IN-3 (compound 2) is an orally active PfDHODH inhibitor with strong antimalarial activity (IC₅₀=47 nM). PfDHODH-IN-3 can inhibit the growth of Plasmodium in animals .

Keap1-Nrf2-IN-28	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-28 (SG16) is an orally active Keap1-Nrf2 inhibitor. Keap1-Nrf2-IN-28 shows antioxidant capability and induces the upregulation of Nrf2, HO-1, GCLM, and Akr1c1. Keap1-Nrf2-IN-28 attenuates APAP (HY-66005)-induced acute liver injury .

TRPV1-IN-2	TRP Channel	Neurological Disease
TRPV1-IN-2 ((R)-32) is a TRPV1 inhibitor. TRPV1-IN-2 has protective effects on ED epilepsy models .

CYP51-IN-22	Cytochrome P450 Fungal	Infection
CYP51-IN-22, the non-deuterated analog of CYP51-IN-23-d₃ (HY-174353S), is a potent and broad-spectrum CYP51 inhibitor.CYP51-IN-22 inhibits Aspergillus fumigatum with a *MIC₈₀* of 1 μg/mL. CYP51-IN-22 can prevent fungal phase transformation and biofilm formation. CYP51-IN-22 exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-22 can be used for the study of invasive fungal infections (IFIs) .

CYP51-IN-23-d3	Isotope-Labeled Compounds Cytochrome P450 Fungal	Infection
CYP51-IN-23-d₃ is a potent and broad-spectrum CYP51 inhibitor with a *MIC₈₀* of 1 μg/mL against Aspergillus fumigatum. CYP51-IN-23-d₃ can prevent fungal phase transformation and biofilm formation. CYP51-IN-23-d₃ exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-23-d₃ can be used for the study of invasive fungal infections (IFIs) .

BuChE-IN-15	Cholinesterase (ChE) FAAH	Neurological Disease
BuChE-IN-15 (compound D12) is a selective BuChE/FAAH dual inhibitor with and show IC₅₀ values of 81 and 400 nM for hBuChE and hFFAH, respectively. BuChE-IN-15 possesses good BBB penetration, and shows neuroprotection.BuChE-IN-15 can be used for study of Alzheimer .

EGFR/HER2-IN-7	EGFR	Cancer
EGFR/HER2-IN-7 is a potent anticancer agent with high selectivity against MCF-7 breast cancer cells. EGFR/HER2-IN-7 is a EGFR/HER2 kinase and DHFR inhibitor, with IC₅₀s of 0.18 μM (EGFR), 0.146 μM (HER2), respectively. EGFR/HER2-IN-7 shows moderate inhibition on DHFR (IC₅₀=0.907 μM) .

EGFR/HER2/DHFR-IN-1	EGFR	Cancer
EGFR/HER2/DHFR-IN-1 is a potent anticancer agent with high selectivity against MCF-7 breast cancer cells. EGFR/HER2/DHFR-IN-1 is a multiple inhibitor of EGFR/HER2 kinase and DHFR, with IC₅₀s of 0.153 μM, 0.108 μM, 0.291 μM, respectively. EGFR/HER2/DHFR-IN-1 arrests cell cycle at G1/S and induces cells apoptosis .

NLRP3-IN-45	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-45 (D6) is an inhibitor of NLRP3 inflammasome activation, inhibiting the activity of IL-1β (IC₅₀=41.79 nM). NLRP3-IN-45 exerts its effects without affecting the initial stage of NLRP3 inflammasome activation. NLRP3-IN-45 specifically inhibits the activation of NLRP3 inflammasome in the LPS-induced acute lung injury (ALI) mouse model .

AChE/BuChE-IN-4	Cholinesterase (ChE)	Neurological Disease
AChE/BuChE-IN-4(compound 4a) is aorally activeandbrain-penetrantmultitarget-directedAChE/BuChEinhibitor againstAChEandBuChE, with theIC₅₀of 2.08 and 7.41 μM .

TZ-NBD	Fluorescent Dye	Others
TZ-NBD is a dual-channel sensitive fluorescence probe that exhibits fast response, and excellent selectivity to detect biothiols in vitro and in vivo .

VEGFR-2-IN-35	VEGFR	Cancer
VEGFR-2-IN-35 (compound 7) is a potent VEGFR-2 inhibitor with IC₅₀=37 nM. VEGFR-2-IN-35 inhibits MCF-7 and HCT 116 cancer cells with IC₅₀ values of 10.56 and 7.07 μM, respectively .

Nek2-IN-6	NEKs	Cancer
Nek2-IN-6 (Compound 28e) is a potent never in mitosis (NIMA) related kinase 2 (Nek2) inhibitor .

CYP4A11/CYP4F2-IN-2	Cytochrome P450	Metabolic Disease
CYP4A11/CYP4F2-IN-2 (compound 15) is an orally available inhibitor of CYP4A11/4F2 with IC₅₀s of 120 nM and 220 nM, respectively. CYP4A11/CYP4F2-IN-2 inhibits 20-HETE production in rat kidney and has potential inhibitory effects on diabetic nephropathy and autosomal dominant polycystic kidney disease .

PNU-140975 BVT.3531	Potassium Channel	Neurological Disease
PNU-140975 (BVT.3531) is a novel and potent bioactive compound. PNU-140975 can reduce body weight and activates K_ATP channel in isolated arcuate neurons in rats .

SR-17398	ULK	Cancer
SR-17398 is an inhibitor for Unc-51-Like Kinase 1 (ULK1) with an IC₅₀ of 22.4 μM .

DHFR-IN-15	Dihydrofolate reductase (DHFR)	Cancer
DHFR-IN-15 (compound 34) is a dihydrofolate reductase (DHFR) inhibitor with potential anticancer activity. DHFR-IN-15 effectively binds to DHFR in cells, reducing DHFR levels to 10 nM .

hCAIX-IN-19	Carbonic Anhydrase	Cancer
hCAIX-IN-19 is a sulfonamides inhibitor against hCA IX with an inhibition constant (K_I) of 6.2 nM and show good selectivity over hCA I (hCA I/ hCA IX = 117) .

DHFR-IN-14	Dihydrofolate reductase (DHFR)	Cancer
DHFR-IN-14 (compound 32) is a pyrimethamine (Pyr)-type, dihydrofolate reductase (DHFR) inhibitor with potential anticancer activity .

FLT3-IN-32 hydrochloride	FLT3 Apoptosis STAT p38 MAPK Akt	Cancer
FLT3-IN-32 hydrochloride is a potent and orally active FLT3 inhibitor with an IC₅₀s of 0.29 nM, 0.77 nM and 2.07 nM against FLT3-ITD, FLT3-D835Y and FLT-N676K. FLT3-IN-32 hydrochloride reduces the phosphorylation of FLT3 and its downstream signaling molecules (STAT5, MAPK, AKT) to induce FLT3-mutated Ba/F3 cells apoptosis. FLT3-IN-32 hydrochloride shows significant anti-tumor efficacy in n the MV4-11 xenograft model. FLT3-IN-32 hydrochloride can be used for the study of acute myeloid leukemia (AML) .

Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11)	TNF Receptor Dengue Virus	Infection Inflammation/Immunology Cancer
Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) is a rat-derived IgG1 antibody inhibitor, targeting to TNF-alpha/TNFSF2. Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) neutralizes of TNF-alpha. Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) can be used for the researches of cancer, infection and immunology, such as dengue virus and B16K1 tumor .

FLT3-IN-32 TFA	FLT3	Cancer
FLT3-IN-32 TFA is a potent FLT3 inhibitor with an IC₅₀s of 2.40 nM and 3.83 nM against FLT3-ITD and FLT3-D835Y. FLT3-IN-32 TFA inhibits proliferation/survival of human MV4-11 cells with an IC₅₀ of 0.07 nM. FLT3-IN-32 TFA can be used for the study of acute myeloid leukemia (AML) .

α-Acetyldigoxin	Biochemical Assay Reagents	Cardiovascular Disease
α-Acetyldigoxin can be used in heart failure related research and is orally available. The bioavailability of α-Acetyldigoxin is lower than that of β-Acetyldigoxin when administered orally and intravenously .

QTZ	Fluorescent Dye	Others
QTZ is a bioluminescence agent for in vivo imaging. QTZ has red-shifted emission and yields very little background. QTZ is a coelenterazine analog with the 4-quinolinyl substitution at the C8 position of the imidazopyrazinone core .

L-870810	HIV	Infection
L-870810 is a potent HIV-1 IN chain transfer inhibitor with antiviral activity .

FR186054	Acyltransferase	Metabolic Disease
FR186054 is an oral active acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor with the IC₅₀ of 99 nM. FR186054 shows hypocholesterolemic effect and can be used for study of hypercholesterolemia and atherosclerosis .

Lauroylcarnitine chloride	Others	Others
Lauroylcarnitine chloride enhances the absorption of salmon calcitonin in rats. Also in determining in situ bioavailability, increased availability of Lucifer yellow and decreased expression of claudin-4 protein in the colon .

SIM-6080	Calcium Channel	Metabolic Disease
SIM-6080 is a calcium antagonist and inhibits the proliferation of rat aortic myocytes and reduces aortic atherosclerosis in rabbits .

KF-392	Others	Others
KF-392 is an orally active antiulcer agent .

Ribulose 1,5-bisphosphate RuBP	Endogenous Metabolite	Metabolic Disease
Ribulose 1,5-bisphosphate (RuBP) is an intermediate in photosynthesis that can be metabolized to 3-phosphoglycerate by ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco), a key enzyme in the Calvin-Benson-Bassham cycle .

AlF-NOTA-c-d-VAP	Radionuclide-Drug Conjugates (RDCs) HSP	Cancer
AlF-NOTA-c-d-VAP is a peptide positron emission tomography (PET) probe that used for targeted tumor imaging of GRP78. AlF-NOTA-c-d-VAP demonstrates high stability in vitro and in vivo .

Motavizumab MEDI-524	RSV	Infection
Motavizumab (MEDI-524) is an anti-human RSV (respiratory syncytial virus) monoclonal antibody. Motavizumab can be used in respiratory syncytial virus infection in high-risk infants research .

BTF	Orexin Receptor (OX Receptor)	Neurological Disease
BTF shows a selective binding affinity for OX1R with the K_i values of 2.33 nM and 62.8 nM of OX1R and OX2R, respectively .

MN-25	Cannabinoid Receptor TNF Receptor	Neurological Disease Inflammation/Immunology
MN-25 (compound 4a) is an orally active indolpyridone that serves as a novel cannabinoid ligand. MN-25 has K_i of 245 nM and 11 nM for CB1 and CB2. MN-25 has CB2 agonist activity and inhibits TNF-R release in human peripheral blood mononuclear cells in vitro with an IC₅₀ of 33 μM. MN-25 shows efficacy in a mouse acute inflammation model at oral doses up to 50 mg/kg ^>[1].

DSM74	Parasite	Infection
DSM74 (compound 21) is an orally active and potent antimalarial inhibitor of PfDHODH (IC50=0.28 μM) and PbDHODH (IC50=0.38 μM). DSM74 inhibits the growth of Plasmodium in animals .

BN-82685 IRC-083065	Phosphatase	Cancer
BN-82685 is a a quinone-based CDC25 inhibitor with IC₅₀ of 201 nM, 117 nM, 109 nM, 160 nM, 249 nM, for CDC25C, CDC25C-cat, CDC25A, CDC25B2, CDC25B3, respectively. BN-82685 plays an important role in cancer research .

Dexylosyltubeimoside Ⅲ	Others	Cancer
Dexylosyltubeimoside Ⅲ (compound 3) is a cyclic disoside that can be isolated from Actinostemma lobatum MAXIM. Dexylosyltubeimoside Ⅲ has in vitro anticancer activity and inhibits the growth of human esophageal cancer cell line ECA109 (IC50=22.37 μM), lung cancer cell line A549 (IC50=27.27 μM) and gastric cancer cell line MGC-803 (IC50=36.85 μM) .

ST-148 maleate	Flavivirus Dengue Virus	Infection
ST-148 maleate is a potent and orally active DENV inhibitor. ST-148 maleate shows antiviral efficacy and low cell toxicity. ST-148 alters the interaction between lipid droplets and the C protein, thereby inhibiting viral replication. .

Ethynyl estradiol 3-sulfate 17α-Ethynylestradiol-3-sulfate; EE-3-SO4	Biochemical Assay Reagents	Cardiovascular Disease
Ethynyl estradiol 3-sulfate (17α-Ethynylestradiol-3-sulfate; EE-3-SO4) can prolong the median survival time of rats in an acute severe blood loss model by approximately 6 times, with a 6-hour survival rate of 80%.

G36	Estrogen Receptor/ERR	Endocrinology Cancer
G-36 is a cell-permeable nonsteroidal antagonist of the G protein-coupled estrogen receptor (GPER/GPR30), which selectively inhibits estrogen-mediated PI3K activation through GPER, rather than Erα. G-36 also inhibits estrogen-mediated calcium mobilization (IC₅₀=112 nM). G-36 is promising for research in the field of cancer .

Antibacterial agent 154	Bacterial	Infection
Antibacterial agent 154 (compound 7) is a derivative of Fluoroqinolones and is an orally effective antibacterial agent. Antibacterial agent 154 inhibits Gram-positive and Gram-negative bacteria. Antibacterial agent 154 demonstrated in vivo efficacy in a mouse model of staphylococcal sepsis .

Albifylline A 81-3138; HWA-138	Phosphodiesterase (PDE)	Endocrinology
Albifylline (A 81-3138; HWA-138) is a Xanthine (HY-W017389) derivate. Albifylline reduces the shock-induced leukocyte adhesions to the sinusoidal endothelium in the liver after hemorrhagic shock and improves microvascular blood flow in the liver .

Cat. No.	Product Name	Type

HY-D1809

Vari Fluor 405-Streptavidin

Dyes

Vari Fluor 405-Streptavidin is a dye marker of Vari Fluor-streptavidin consisting of labeling streptavidin with a Vari Fluor series of fluorescent probes. Streptavidin is a high-affinity tetramer protein, each tetramer consisting of four identical streptavidin subunits. Streptavidin binds to biotin specifically via a reversible non-covalent effect. Streptavidin can achieve rapid and efficient detection of biotin markers, and is often used in immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), immunohistochemical staining (IFH), in situ hybridization (ISH) and other experiments. Ex/Em=405 nm/431 nm.

HY-D1805

Vari Fluor 647-Streptavidin

Dyes

Vari Fluor 647-Streptavidin is a dye marker of Vari Fluor-streptavidin consisting of labeling streptavidin with a Vari Fluor series of fluorescent probes. Streptavidin is a high-affinity tetramer protein, each tetramer consisting of four identical streptavidin subunits. Streptavidin binds to biotin specifically via a reversible non-covalent effect. Streptavidin can achieve rapid and efficient detection of biotin markers, and is often used in immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), immunohistochemical staining (IFH), in situ hybridization (ISH) and other experiments. Ex/Em=650 nm/665 nm.

HY-D1808

Vari Fluor 488-Streptavidin

Dyes

Vari Fluor 488-Streptavidin is a dye marker of Vari Fluor-streptavidin consisting of labeling streptavidin with a Vari Fluor series of fluorescent probes. Streptavidin is a high-affinity tetramer protein, each tetramer consisting of four identical streptavidin subunits. Streptavidin binds to biotin specifically via a reversible non-covalent effect. Streptavidin can achieve rapid and efficient detection of biotin markers, and is often used in immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), immunohistochemical staining (IFH), in situ hybridization (ISH) and other experiments. Ex/Em=490 nm/515 nm.

HY-D1804

Vari Fluor 680-Streptavidin

Dyes

Vari Fluor 680-Streptavidin is a dye marker of Vari Fluor-streptavidin consisting of labeling streptavidin with a Vari Fluor series of fluorescent probes. Streptavidin is a high-affinity tetramer protein, each tetramer consisting of four identical streptavidin subunits. Streptavidin binds to biotin specifically via a reversible non-covalent effect. Streptavidin can achieve rapid and efficient detection of biotin markers, and is often used in immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), immunohistochemical staining (IFH), in situ hybridization (ISH) and other experiments. Ex/Em=680 nm/701 nm.

HY-D1807

Vari Fluor 555-Streptavidin

Dyes

Vari Fluor 555-Streptavidin is a dye marker of Vari Fluor-streptavidin consisting of labeling streptavidin with a Vari Fluor series of fluorescent probes. Streptavidin is a high-affinity tetramer protein, each tetramer consisting of four identical streptavidin subunits. Streptavidin binds to biotin specifically via a reversible non-covalent effect. Streptavidin can achieve rapid and efficient detection of biotin markers, and is often used in immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), immunohistochemical staining (IFH), in situ hybridization (ISH) and other experiments. Ex/Em=555 nm/565 nm.

HY-D1806

Vari Fluor 594-Streptavidin

1 Publications Verification

Dyes

Vari Fluor 594-Streptavidin is a dye marker of Vari Fluor-streptavidin consisting of labeling streptavidin with a Vari Fluor series of fluorescent probes. Streptavidin is a high-affinity tetramer protein, each tetramer consisting of four identical streptavidin subunits. Streptavidin binds to biotin specifically via a reversible non-covalent effect. Streptavidin can achieve rapid and efficient detection of biotin markers, and is often used in immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), immunohistochemical staining (IFH), in situ hybridization (ISH) and other experiments. Ex/Em=590 nm/617 nm.

HY-D2334

AlF-NOTA-c-d-VAP	Dyes
AlF-NOTA-c-d-VAP is a peptide positron emission tomography (PET) probe that used for targeted tumor imaging of GRP78. AlF-NOTA-c-d-VAP demonstrates high stability in vitro and in vivo .

HY-D2204

SHP1-IN-1	Fluorescent Dyes/Probes
SHP1-IN-1 (compound 5p) is a fluorescent probe for the protein tyrosine phosphatase SHP1 containing the Src homology 2 domain. SHP1-IN-1 has SHP1 inhibitory activity, selectivity for Fe ³⁺ ions and good fluorescence properties. SHP1-IN-1 exhibits aggregation post-quenching (ACQ) effect, good interference immunity and low detection limit (5.55 μM) .

HY-162051

CYP1B1-IN-6	Fluorescent Dyes/Probes
CYP1B1-IN-6 (compound 19) is a fluorescence molecular probes which inhibits CYP1B1 activity. CYP1B1-IN-6 can identify tumor sites in fluorescence imaging and photoacoustic imaging modes .

HY-13319G

JNK-IN-8 (GMP) JNK Inhibitor XVI (GMP)	Fluorescent Dye
JNK-IN-8 (JNK Inhibitor XVI) (GMP) is JNK-IN-8 (HY-13319) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. JNK-IN-8 is a potent JNK inhibitor with IC₅₀s of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively .

HY-141432G

NX-1607 (GMP) Cbl-b-In-3 (GMP)	Fluorescent Dye
NX-1607 (Cbl-b-IN-3) (GMP) is a GMP-grade NX-1607 (HY-141432). GMP-grade small molecules can be used as adjuvant agents in cell therapy. NX-1607 (GMP) enhances antigen recall, reduces T cell exhaustion and increases cytokine production. NX-1607 is an inhibitor of Cbl-b (an E3 enzyme) .

HY-14176G

Compound E (GMP) γ-Secretase-In-1 (GMP)	Fluorescent Dye
Compound E (GMP) is a GMP-grade Compound E (HY-14176). GMP-grade small molecules can be used as adjuvant reagents in cell therapy. Compound E is a γ-secretase inhibitor. Compound E inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC₅₀ values of 0.24, 0.37, and 0.32 nM, respectively .

HY-D0367

Fluorescent Brightener 28 (25% in water)

Calcofluor White M2R

Fluorescent Dyes/Probes

Fluorescent brightener 28 is a fluorescent whitening agent commonly used in the padding process of the textile industry. Fluorescent brightener 28 is capable of staining polysaccharides such as cellulose, and when the plasma membrane ruptures, it also weakly stains the cytoplasm and strongly stains the cell nucleus. Additionally, Fluorescent brightener 28 can be utilized to detect intracellular chitin in living cells. Fluorescent Brightener 28 also is a visible light emitting diode (LED)-light sensitive photoinitiator for free radical photopolymerizations .

Cat. No.	Product Name	Type

HY-167004A

IAJD249	Drug Delivery
IAJD249 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. IAJD249 can be used in the preparation of liposomes .

HY-167004

IAJD93	Drug Delivery
IAJD93 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. IAJD93 can be used in the preparation of liposomes .

HY-167012

306Oi9-cis2	Drug Delivery
306Oi9-cis2 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. 306Oi9-cis2 can be used in the preparation of liposomes .

HY-W250152

Polycytidylic acid potassium	Biochemical Assay Reagents
Polycytidylic acid potassium is an immunostimulant and synthetic double-stranded RNA. Polycytidylic acid potassium can be used experimentally to model viral infections in vivo. Polycytidylic acid potassium is a common tool in immune system research .

HY-167003

L16	Drug Delivery
L16 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. L16 can be used in the preparation of liposomes .

HY-167011

Al-28	Drug Delivery
Al-28 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. Al-28 can be used in the preparation of liposomes .

HY-167015

1O14	Drug Delivery
1O14 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. 1O14 can be used in the preparation of liposomes .

HY-B2241A

Potassiumalum, for cell culture

AlumInum potassium sulfate dodecahydrate, for cell culture

Cell Assay Reagents

Potassiumalum, for cell culture (Aluminum potassium sulfate dodecahydrate, for cell culture) is an egg white adjuvant. Potassiumalum, for cell culture acts as a mordant to help dyes bind to tissue components, enhancing the staining effect and stability during staining. Potassiumalum, for cell culture can induce allergic reactions in mice. Potassium alum, for cell culture can be used in research for bacterial and tissue staining .

HY-167002

RM 137-15	Drug Delivery
RM 137-15 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. RM 137-15 can be used in the preparation of liposomes .

HY-160276

DOPE-PEG-Fluor 555,MW 5000	Drug Delivery
DOPE-PEG-Fluor 555, MW 5,000 is consist of a DOPE phospholipid which is an unsaturated phospholipid and a Fluor 555 dye which is a bright orange cyanine dye that can be used in fluorescence microscopy, FRET and other in vivo imaging techniques.

HY-150145

Cy5-UTP	Gene Sequencing and Synthesis
Cy5-UTP is a substrate for terminal deoxynucleotidyl transferase (TdT). Cy5-UTP can be used to lable RNA probes through in vitro transcription (Excitation/Emission: 650/665 nm). Cy5-labeled mRNA emits orange fluorescence .

HY-163624

Bfl-1-IN-2	Biochemical Assay Reagents
Bfl-1-IN-2 (Compound 13) is a reversible and covalent inhibitor of Bfl-1 (IC₅₀: 4.3 μM). Bfl-1-IN-2 acts by binding to Cys55 of Bfl-1 .

HY-W070306

PDK1-IN-1	Biochemical Assay Reagents
PDK1-IN-1 (Compound 2-11) is a PDK1 inhibitor, and can be used for research of myeloproliferative disorders or cancer .

HY-75070

(+)-1-(1-Naphthyl)ethylamine

Biochemical Assay Reagents

(+)-1-(1-Naphthyl)ethylamine ((+)-1-(1-NEA)) is a chiral modifier used to introduce enantioselectivity in catalytic hydrogenation reactions. 1-NEA can undergo H-D exchange with D2 in solution to form N?D bonds. That is, 1-NEA can complete Pt surface adsorption and protonation through amine N atoms, indicating that NEA molecules have the potential to impart enantioselectivity to Pt hydrogenation catalysts .

HY-Y0407A

Tetrapropylammonium hydroxide (40% w/w in water)

TPAOH (40% w/w In water)

Biochemical Assay Reagents

Tetrapropylammonium hydroxide (40% w/w in water)It is a compound belonging to the class of quaternary ammonium compounds and is a strong base with cationic properties. Tetrapropylammonium hydroxide (40% w/w in water)It is usually used as a phase transfer catalyst to promote the transfer of reactants between immiscible phases in various organic synthesis reactions. It is also used in the production of semiconductors, especially the manufacture of thin-film transistors and other electronic devices.

HY-W392173

Lauryl glucoside (50% in water)	Surfactants
Lauryl glucoside (50% in water) is a non-ionic surfactant with high cleansing ability, high foaming ability and low cost .

HY-W127728

Tricholine citrate (65% in water)	Biochemical Assay Reagents
Tricholine Citrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-Y1242A

Choline hydroxide (46% in water)	Biochemical Assay Reagents
Choline hydroxide, 46 wt.% in water is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-116956A

L-Erythrose (solution) (70% in water)	Carbohydrates
L-Erythrose (solution) (70% in water) is an aldose carbohydrate that has been used in glycation studies and to characterize erythrose reductase activity.

HY-W130648

Sodium 2-ethylhexyl sulfate (40% in water)

Biochemical Assay Reagents

Sodium 2-ethylhexyl sulfate (40% in water) is an anionic surfactant commonly used as a detergent, wetting agent, and emulsifier in various industrial processes, especially in the production of personal care products, cleaning agents, and textile auxiliaries. Sodium 2-ethylhexyl sulfate (40% in water) has unique chemical properties that make it an effective ingredient in many applications, helping to reduce surface tension and enhance cleaning power.

HY-156261

Beef extract	Microbial Culture
Beef extract is a common ingredient in the preparation of biological culture media .

HY-W250170

Decyl glucoside (60% in water) Octyldecyl glucoside	Biochemical Assay Reagents
Decyl glucoside is a mild nonionic surfactant. Decyl glucoside can be derived from renewable raw materials such as glucose and fatty alcohols from coconut oil or palm kernel oil. Decyl glucoside is known for its excellent foaming and cleaning properties.

HY-150145A

Cy5-UTP sodium (10mM in Water)	Gene Sequencing and Synthesis
Cy5-UTP sodium (10mM in Water) is a cyanine5-labeled UTP analogue that can produce fluorescent probes in vitro transcription reactions with excitation/emission wavelengths of 650/665 nm. Cy5-UTP sodium can be used in FISH, polychromatic fluorescence analysis, especially the two-color expression array combined with Cy5-UTP .

HY-132145B

5-Propargylamino-ddUTP sodium (100mM in water)	Gene Sequencing and Synthesis
5-Propargylamino-ddUTP (sodium) (100mM in water) is a kind of biochemical reagent.

HY-N2024B

Maltose solution, 20% in H2O	Biochemical Assay Reagents
Maltose solution, 20% in H2O is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-125139

omega-3 Arachidonic acid ethyl ester, in ethanol, 98%

ω-3 Arachidonic acid ethyl ester, In ethanol, 98%; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester, In ethanol, 98%

Drug Delivery

omega-3 Arachidonic acid ethyl ester, in ethanol, 98% is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.

HY-W673626

Etidronic acid,60% in water monohydrate Etidronate monohydrate; HEDPA monohydrate; HEDP monohydrate	Cell Assay Reagents
Etidronic acid,60% in water (Etidronate) monohydrate is a strong complexing agent that can be used as a chelating agent to remove heavy metals from water .

HY-Y0971

Tetrabutylammonium (fluoride) (solution),1M in THF

TBAF

Biochemical Assay Reagents

Tetrabutylammonium fluoride is an organic compound containing both ammonium and fluorine functional groups. It is commonly used as a reagent in various chemical synthesis applications, especially as a source of fluoride ions for nucleophilic reactions. Tetrabutylammonium fluoride has several properties that make it suitable for these applications, including its high solubility in polar solvents and its ability to selectively activate certain chemical bonds. In addition, it can be used as a catalyst for organic reactions and as an electrolyte for batteries.

HY-13319G

JNK-IN-8 (GMP) JNK Inhibitor XVI (GMP)	Biochemical Assay Reagents
JNK-IN-8 (JNK Inhibitor XVI) (GMP) is JNK-IN-8 (HY-13319) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. JNK-IN-8 is a potent JNK inhibitor with IC₅₀s of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively .

HY-W243303M

Poly(acrylic acid) (MW 100000) (35% in water)	Drug Delivery
Poly(acrylic acid) (Mv 100000) is a kind of biochemical reagent.

HY-141432G

NX-1607 (GMP) Cbl-b-In-3 (GMP)	Biochemical Assay Reagents
NX-1607 (Cbl-b-IN-3) (GMP) is a GMP-grade NX-1607 (HY-141432). GMP-grade small molecules can be used as adjuvant agents in cell therapy. NX-1607 (GMP) enhances antigen recall, reduces T cell exhaustion and increases cytokine production. NX-1607 is an inhibitor of Cbl-b (an E3 enzyme) .

HY-132145A

5-Propargylamino-ddUTP triethylamine (100mM in water)	Gene Sequencing and Synthesis
5-Propargylamino-ddUTP (triethylamine) (100mM in water) is a kind of biochemical reagent.

HY-91018

Trimethyl[3-(trimethoxysilyl)propyl]ammonium (chloride) (50% in methanol) N-[3-(Trimethoxysilyl)propyl]-N,N,N-trimethylammonium chloride, 50% In methanol	Biochemical Assay Reagents
Trimethyl[3-(trimethoxysilyl)propyl]ammonium (chloride) (50% in methanol) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W010221

Phenyltrimethylammonium hydroxide TrimethylanilInium hydroxide (ca. 8.5% In Methanol)	Biochemical Assay Reagents
N,N,N-Trimethylbenzenaminium hydroxide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-14176G

Compound E (GMP) γ-Secretase-In-1 (GMP)	Biochemical Assay Reagents
Compound E (GMP) is a GMP-grade Compound E (HY-14176). GMP-grade small molecules can be used as adjuvant reagents in cell therapy. Compound E is a γ-secretase inhibitor. Compound E inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC₅₀ values of 0.24, 0.37, and 0.32 nM, respectively .

HY-120967

(2S)-OMPT (triethylamine), in ethanol:chloroform (1:1), 98%

Cell Assay Reagents

(2S)-OMPT (triethylamine), in ethanol:chloroform (1:1), 98%, is commonly used as a ligand in asymmetric catalysis, especially in the enantioselective synthesis of bioactive molecules such as amino acids and drugs. (2S)-OMPT triethylamine has unique chemical properties that allow it to selectively bind certain metal complexes and activate them in a way that favors the formation of specific enantiomers.

HY-D0176

Dextrosil KA (65% in water) (3-Chloro-2-hydroxypropyl)trimethylammonium chloride	Biochemical Assay Reagents
Dextrosil KA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-157881

2-Mercaptoethanesulfonic acid (ampule,3.0M±0.1M in H2O) β-Mercaptoethanesulfonic acid (ampule,3.0M±0.1M In H2O)	Buffer Reagents
2-Mercaptoethanesulfonic acid (ampule,3.0M±0.1M in H2O) is a biochemical reagent that can be used for protein sequence analysis .

HY-155743A

ddUTP (lithium), 100mM in H2O 2',3'-DideoxyuridIne-5'-triphosphate lithium	Gene Sequencing and Synthesis
ddUTP (lithium), 100mM in H₂O is a nucleotide analog that can be incorporated into DNA, RNA, or other nucleic acids. ddUTP (lithium), 100mM in H₂O can be used to prepare DNA/RNA hybridization experiments, such as Southern blots and Northern blots.

HY-W106486

Diallyldimethylammonium (chloride) (60% in water)

N,N-Dimethyl-N-2-propenyl-2-propen-1-amInium chloride

Biochemical Assay Reagents

Diallyldimethylammonium chloride (60% in water) is a quaternary ammonium compound belonging to the class of alkylammonium salts. The compound is widely used as a cationic monomer in the production of water-soluble polymers, especially in the manufacture of flocculants and coagulants for water treatment processes. In addition, it can be used as an antimicrobial agent, surfactant or adhesive in various industrial applications. Its unique chemical properties make it an important ingredient in a variety of industrial processes, including papermaking, textiles and personal care products.

HY-D0910

5-Bromo-6-chloro-1H-indol-3-yl acetate

Biochemical Assay Reagents

5-Bromo-6-chloro-1H-indol-3-yl acetate, a member of the indole family, is a derivative of the aromatic heterocyclic compound indole. It has been used in a variety of research settings, including studies of enzyme kinetics and protein-ligand interactions. 5-Bromo-6-chloro-1H-indol-3-yl acetate is a biomaterial or organic compound that can be used as a biomaterial or organic compound related to life science research .

Cat. No.	Product Name	Target	Research Area

HY-P3516

Barusiban FE-200440	Oxytocin Receptor	Endocrinology
Barusiban (FE-200440) is an oxytocin receptor (OT-R) antagonist (K_i=0.8 nM), inhibits OT-induced contraction. Barusiban can be used in preterm labor (PTL), in vitro fertilisation (IVF) and infertility research .

HY-P5352

Hyaluronan-IN-1	Peptides	Others
Hyaluronan-IN-1 is a biological active peptide. (This 12 amino acids peptide is a hyaluronan inhibitor (HA), a high molecular weight glycosaminoglycan expressed abundantly in the extracellular matrix and on cell surfaces. This peptide shows specific binding to soluble, immobilized, and cell-associated forms of HA, and it inhibits leukocyte adhesion to HA substrates almost completely.)

HY-P10150

IN-2-LF	Bacterial	Infection
IN-2-LF is an inhibitor of lethal factor. IN-2-LF also inhibits furin with an IC₅₀ of 2 μM. IN-2-LF enhances protection against anthrax lethal toxin when in combination with D6R .

HY-P0162

HCV-IN-4	HCV	Infection
HCV-IN-4 is a potent and orally active HCV NS5A inhibitor, shows great potency against GT1a, GT2b, GT3a, GT1a Y93H and GT1a L31V, with EC₉₀s of 3 pM, 0.3 nM, 0.01 nM, 0.5 nM and 0.02 nM, respectively .

HY-144292

HDAC-IN-30	HDAC	Cancer
HDAC-IN-30 is a novel multi-target HDAC inhibitor, including HDAC1 (IC₅₀=13.4 nM),HDAC2 (IC₅₀=28.0 nM), HDAC3 (IC₅₀=9.18 nM), HDAC6 (IC₅₀=42.7 nM), HDAC8 (IC₅₀=131 nM). HDAC-IN-30 exhibits potent antitumor efficacy .

HY-144334

CHIKV-IN-3	CHIKV DNA/RNA Synthesis	Infection
CHIKV-IN-3 is a potent against two low-passage CHIKV inhibitor with EC₅₀ values of 1.55 and 0.14 μM for CHIKV-122508 and CHIKV-6708, respectively. CHIKV-IN-3 acts on the host cells to interfere with the viral replication. CHIKV-IN-3 displays minimal cytotoxic liability (CC₅₀>100 μM). Prophylactic effect .

HY-P4543

HIV-IN petide	HIV HIV Protease	Infection
HIV-IN petide is a competitive inhibitor of HIV-1 protease (K_i=50 nM) .

HY-P3426

BACE1-IN-10	Beta-secretase	Cancer
BACE1-IN-10 is a potent BACE1 Inhibitor. BACE1-IN-10 shows sub-micromolar activity against recombinant BACE1 (rBACE1) .

HY-144277

RIPK1-IN-12	RIP kinase Necroptosis	Inflammation/Immunology
RIPK1-IN-12 is a potent RIPK1 inhibitor. RIPK1-IN-12 inhibits necroptosis in both human and mouse cells, with EC₅₀ values of 1.6 and 2.9 nM, respectively .

HY-P10118

Cathepsin L-IN-3	Cathepsin	Others
Cathepsin L-IN-3 is a tripeptide-sized cathepsin L inhibitor.

HY-P10113

STAT3-IN-23	STAT	Cancer
STAT3-IN-23 (PYLKTK) is a potent STAT3* inhibitor .

HY-156430

MMP-7-IN-3	MMP	Cancer
MMP-7-IN-3 is a potent and selective inhibitor of MMP-7. MMP-7-IN-3 suppresses kidney fibrosis progression in a mouse model with unilateral ureteral obstruction .

HY-173076

HDAC11-IN-1	HDAC YAP	Inflammation/Immunology
HDAC11-IN-1 (Compound 14-N ^C6OH) is a selective macrocyclic inhibitor of HDAC11 with a K_i of 40 nM. HDAC11-IN-1 exhibits good cell permeability and can inhibit the expression of YAP1 and SOX2 .

HY-P3822

PRMT5-IN-23	Histone Methyltransferase	Cancer
PRMT5-IN-23 (compound 50) is an inhibitor of protein arginine methyltransferase 5 (PRMT5) with anti-tumor activity. PRMT5 is a type of protein arginine methyltransferase, and is a new anti-tumor target related to epigenetic modification .

HY-153563

MMP-7-IN-2	MMP	Cancer
MMP-7-IN-2 is a potent and selective inhibitor of MMP7 with an IC₅₀ value of 16 nM. MMP-7-IN-2 can be used for the research of diseases such as cancer and fibrosis .

HY-P2244

YAP-TEAD-IN-1 2 Publications Verification	YAP	Cancer
YAP-TEAD-IN-1 is a potent and competitive inhibitor of?YAP–TEAD interaction (IC₅₀=25 nM). YAP-TEAD-IN-1 is a 17mer peptide and shows a higher the binding affinity to TEAD1 (K_d=15 nM) than YAP (50-171) (K_d=40 nM) .

HY-103048

PD-1/PD-L1-IN 3	PD-1/PD-L1	Cancer
PD-1/PD-L1-IN 3, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and *CD80/PD-L1* interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC₅₀s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 can be used for the research of various diseases, including cancer and infectious diseases .

HY-P10140

JNK-IN-15, Cell-Permeable	JNK	Cancer
JNK-IN-15, Cell-Permeable (JNK inhibitor III) is an inhibitor of JNK. JNK-IN-15, Cell-Permeable can used in study age-related neurodegenerative diseasev .

HY-173076A

HDAC11-IN-1 TFA	HDAC YAP	Inflammation/Immunology
HDAC11-IN-1 (Compound 14-N ^C6OH) TFA is a selective macrocyclic inhibitor of HDAC11 with a K_i of 40 nM. HDAC11-IN-1 TFA exhibits good cell permeability and can inhibit the expression of YAP1 and SOX2 .

HY-P2244A

YAP-TEAD-IN-1 TFA 2 Publications Verification	YAP	Cancer
YAP-TEAD-IN-1 TFA is a potent and competitive peptide inhibitor of YAP-TEAD interaction (IC₅₀=25 nM). YAP-TEAD-IN-1 TFA is a 17mer peptide and shows a higher the binding affinity to TEAD1 (K_d=15 nM) than YAP (50-171) (K_d= 40 nM) .

HY-151250

HIV-1 protease-IN-7	HIV Protease	Infection
HIV-1 protease-IN-7 (compound 16) is an orally active HIV-1 protease inhibitor (IC₅₀=3.52 nM, EC₅₀=37 nM) .

HY-158150

20S Proteasome-IN-5	Proteasome	Cancer
20S Proteasome-IN-5 (Compound 5) is a macrocyclic inhibitor of the 20S Proteasome, with IC₅₀ values of 0.19 and 52.5 μM for ChT-L and PGPH-L activity, respectively .

HY-P10049

TAT-TCL1-Akt-in	Akt	Cancer
TAT-TCL1-Akt-in is an Akt inhibitor .

HY-P3492

SARS-CoV-2-IN-34	SARS-CoV	Infection
SARS-CoV-2-IN-34 (S-20-1) is a blood brain barrier penetrable pan-coronavirus (CoV) fusion inhibitor with broad-spectrum inhibitory activity. SARS-CoV-2-IN-34 effectively inhibits infection by pseudotyped and authentic SARS-CoV-2, and pseudotyped variants of concern (VOCs). SARS-CoV-2-IN-34 shows high affinity to RBD in S1 and HR1 domain in S2 of SARS-CoV-2 S protein. SARS-CoV-2-IN-34 can be used for the research of infection .

HY-P11057

FGGH	Fluorescent Dye	Others
FGGH is a water-soluble peptide-based probe. FGGH performs the sequential detection of Cu ²⁺ and S ^2- by fluorescence and colorimetry with high sensitivity (LOD: 1.42 and 22.2 nM for Cu ²⁺ and S ^2-, respectively), and images both two ions in living cells and zebrafish models with low cytotoxicity. FGGH can be used for in vivo imaging and environmental pollution monitoring research .

HY-103048A

PD-1/PD-L1-IN 3 TFA	PD-1/PD-L1	Cancer
PD-1/PD-L1-IN 3 TFA, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and *CD80/PD-L1* interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 TFA interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC₅₀s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 TFA can be used for the research of various diseases, including cancer and infectious diseases .

HY-P5480

Keap1-Nrf2-IN-16	Keap1-Nrf2	Others
Keap1-Nrf2-IN-16 is a biological active peptide. (KEAP1 binding activity)

HY-P4222

IETD-CHO Caspase-8-In-1	Caspase	Others
IETD-CHO (Caspase-8-IN-1) is a potent caspase-8 inhibitor .

HY-175824

PSD-95/nNOS PPI-IN-1	iGluR NO Synthase Apoptosis Reactive Oxygen Species (ROS)	Neurological Disease
PSD-95/nNOS PPI-IN-1 is a inhibitor targeting the PSD-95/nNOS interaction with potential blood-brain barrier penetration. PSD-95/nNOS PPI-IN-1 binds to the PSD-95 PDZ2 domain with high affinity (K_i = 19.45 μM). PSD-95/nNOS PPI-IN-1 inhibits glutamate-induced excitotoxicity by reducing intracellular ROS levels and inhibiting apoptosis. PSD-95/nNOS PPI-IN-1 significantly reduces cerebral infarct volume in rat tMCAO models. PSD-95/nNOS PPI-IN-1 can be used for the study of acute ischemic stroke .

HY-P10217

PD-1/PD-L1-IN-42	PD-1/PD-L1	Cancer
PD-1/PD-L1-IN-42 (Compound B8.4) is an inhibitor of the interaction between PD-1 and PD-L1, with an EC₅₀ of 0.1 μM. PD-1/PD-L1-IN-42 can be used for the research of cancer immunotherapy .

HY-P10141

JNK-IN-15, Cell-Permeable, Negative Control	JNK	Cancer
JNK-IN-15, Cell-Permeable, Negative Control is a negative control of JNK-IN-15, Cell-Permeable (HY-P10140). JNK-IN-15, Cell-Permeable is an inhibitor of JNK .

HY-P10096

STAT3-IN-22, negative control PYLKTK	Peptides	Others
STAT3-IN-22, negative control (PYLKTK) is a peptide that serves as a control peptide for phosphotyrosine .

HY-149034

Influenza A virus-IN-8 S5	Influenza Virus	Infection Cancer
Influenza A virus-IN-8 (S5) is a macrocyclic peptide with no cytotoxic. Influenza A virus-IN-8 is also a potent Influenza A Virus (IAV) inhibitor (with sufficient protease stability) with IC₅₀s of 6.7 and 6.6 nM for H1 and H5 variants, respectively. Influenza A virus-IN-8 shows good affinitiescan to H1 variants, binds to a conserved region in the HA stem with a K_d of 1.0 nM .

HY-P10099

STAT3-IN-21, cell-permeable, negative control	STAT	Cancer
STAT3-IN-21, cell-permeable, negative control, a peptide, is a negative control for Stat3 activity detection .

HY-137392

Cathepsin L-IN-4 1-Naphthalenesulfonyl-Ile-Trp-CHO	Cathepsin	Others
Cathepsin L-IN-4 is an inhibitor of cathepsin L with IC₅₀ at nanomolar concentrations .

HY-P1139

Cortistatin-8 PCFWKTCK	GHSR	Metabolic Disease
Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals .

HY-P10072A

MK2-IN-5 acetate Hsp25 kInase Inhibitor acetate; Mk2 pseudosubstrate acetate	JNK HSP MAPKAPK2 (MK2) p38 MAPK ERK	Others
MK2-IN-5 (Hsp25 kinase inhibitor) acetate is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 acetate targets the protein interaction domain in the MAPK pathway. MK2-IN-5 acetate inhibits HSP25 and HSP27 phosphorylation .

HY-P10072

MK2-IN-5 Hsp25 kInase Inhibitor; Mk2 pseudosubstrate	ERK JNK p38 MAPK HSP MAPKAPK2 (MK2)	Others
MK2-IN-5 is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 targets the protein interaction domain in the MAPK pathway. MK2-IN-5 inhibits HSP25 and HSP27 phosphorylation .

HY-P10114

STAT3-IN-24, cell-permeable PpYLKTK-mts; STAT3 PI	STAT	Cancer
STAT3-IN-24, cell-permeable (PpYLKTK-mts) is a STAT3 peptide inhibitor. STAT3-IN-24, cell-permeable inhibits recruitment of STAT3 to Jak2 and phosphorylation of Y705, thus preventing the dimerization and the nuclear translocation of STAT3 .

HY-P1459

Sphistin Synthetic Peptide(12-38,Fitc in N-Terminal-Fluorescently Labeled Peptide)	Bacterial	Infection
Sphistin Synthetic Peptide (12-38, Fitc in N-Terminal-Fluorescently Labeled Peptide) is a truncated fragments of Sphistin Synthetic Peptide that shows potent antimicrobial activity.

HY-P5152

Scorpion toxin Tf2	Sodium Channel	Neurological Disease
Scorpion toxin Tf2 is a β-scorpion toxin, which is firstly identified in the venom of the Brazilian scorpion Tityus fasciolatus. Scorpion toxin Tf2 is a Nav1.3 activator, which is a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nociception. Scorpion toxin Tf2 enhances hNav1.3 activation voltage and opens the channel at resting membrane potentials .

HY-P10395

DP50	Opioid Receptor Neuropeptide FF Receptor	Neurological Disease
DP50 is a bifunctional compound that contains an opioid receptor (MOP) agonist and a neuropeptide FF receptor (NPFFR) antagonist. DP50 can be used in analgesia-related research .

HY-W011258

H-Tyr-Phe-OH L-Tyrosyl-L-phenylalanIne	Xanthine Oxidase Angiotensin-converting Enzyme (ACE)	Inflammation/Immunology Cancer
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells .

Cat. No.	Product Name	Target	Research Area

HY-P990794

Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11)	TNF Receptor Dengue Virus	Infection Inflammation/Immunology Cancer
Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) is a rat-derived IgG1 antibody inhibitor, targeting to TNF-alpha/TNFSF2. Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) neutralizes of TNF-alpha. Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) can be used for the researches of cancer, infection and immunology, such as dengue virus and B16K1 tumor .

HY-P99209

Motavizumab MEDI-524	RSV	Infection
Motavizumab (MEDI-524) is an anti-human RSV (respiratory syncytial virus) monoclonal antibody. Motavizumab can be used in respiratory syncytial virus infection in high-risk infants research .

HY-P99590A

Sotatercept (mIgG2a) RAP-011	TGF-β Receptor TGF-beta/Smad	Cardiovascular Disease Metabolic Disease
Sotatercept (mIgG2a) (RAP-011), the murine homolog of Sotatercept (ACE-011) (HY-P99590), is a soluble activin receptor type IIA (ActRIIA) ligand trap. Sotatercept (mIgG2a) inhibits the binding of activin A and other members of the TGF-β superfamily (such as Activin A/B, GDF11 and BMP9/10) to their receptors by combining and neutralizing them, thereby regulating cell proliferation and differentiation. Sotatercept (mIgG2a) mainly inhibits the SMAD2/3 signaling pathway, and can be used in various diseases such as chronic kidney disease. Sotatercept (mIgG2a) reduces the expression of erythropoietic hepcidin (ERFE), regulates iron metabolism, and promotes red blood cell production. Sotatercept (mIgG2a) has a dual effect of promoting bone formation (anabolic) and inhibiting bone resorption (catabolic) .

HY-P991191

REGN-5054	Transmembrane Glycoprotein	Cancer
REGN5054 is a fully human monoclonal IgG1 antibody that binds specifically to human and cynomolgus CD8 expressed on T cells .

HY-P991494

IN-002	RSV	Infection
IN-002 is a human monoclonal antibody (mAb) targeting F, Fusion glycoprotein F0. IN-002 can be used in respiratory syncytial virus (RSV) infections research.

HY-152228

SMYD3-IN-2	Histone Methyltransferase Autophagy	Cancer
SMYD3-IN-2 is a SMYD3 inhibitor against gastric cancer via inducing lethal autophagy. SMYD3-IN-2 has inhibitory for SMYD3 and BGC823 cells with IC₅₀ values of 0.81 μM and 0.75 μM, respectively. SMYD3-IN-2 can be used for the research of cancer .

HY-145771

PD-1/PD-L1-IN-20	PD-1/PD-L1	Cancer
PD-1/PD-L1-IN-20 (Example 21) is a small-molecule inhibitor of the PD-1/PD-L1 protein-protein interaction. PD-1/PD-L1-IN-20 blocks PD-1/PD-L1 with the IC₅₀ of 5.29 nM. PD-1/PD-L1-IN-20 can be used for the research of cancers, infectious diseases and autoimmune diseases .

Species:	Human (52) Rat (2) Mouse (1)
Tag:	His (37) SUMO (3) Tag Free (9) Strep (1) Myc (1) GST (6) MBP (1) Fc (4)
Source:	HEK293 (19) Sf9 insect cells (8) P. pastoris (1) E. coli (27)

Cat. No.	Compare	Product Name	Species	Source

HY-P72569

	IL-1R1 Protein, Human (HEK293, His) InterleukIn-1 receptor type 1; IL-1R-1; IL-1RT-1; InterleukIn-1 receptor alpha; IL-1R-alpha; p80; CD121a	Human	HEK293
	IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (K_d: 0.1-1 nM). IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB and MAPK pathway. IL-1R1 Protein, Human (HEK293, His) is a recombinant human extracellular region of IL-1R1 (L18-T332) with a C-Terminal 6*His tag, which is produced in HEK293 cells.

HY-P72025

	TNF RII/TNFRSF1B Protein, Human (HEK293, hFc) Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; CD120b; Etanercept; TBP-2; TBPII;	Human	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNFRII Protein, Human (HEK293, hFc) is expressed by HEK293 and has a transmembrane region (L23-D257) with hFc tag at the C-terminus.

HY-P71126

	TNF RII/TNFRSF1B Protein, Human (174a.a, HEK293, His) Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; TNFRII; TNF RII	Human	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNFRII Protein, Human (174a.a, HEK293, His) is expressed by HEK293 and has a transmembrane region (K288-S461) with 6*His tag at the C-terminus.

HY-P71914

	TNF RII/TNFRSF1B Protein, Human (183a.a) CD120b; p75; p75 TNF receptor; p75TNFR; p80 TNF alpha receptor; p80 TNF-alpha receptor; Soluble TNFR1B variant 1; TBP-2; TBPII; TNF R II; TNF R2; TNF R75; TNF-R2; TNF-RII; TNFBR; TNFR-II; TNFR1B; TNFR2; TNFR80; TNFRII ; Tnfrsf1b; TNR1B_HUMAN; Tumor necrosis factor beta receptor; Tumor necrosis factor bIndIng proteIn 2; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor type II; Tumor necrosis factor-bIndIng proteIn 2	Human	E. coli
	The TNFRII protein is a receptor with high affinity for TNFSF2/TNF-α and low affinity for TNFSF1/lymphotoxin-α, and plays a key role in mediating the metabolic effects of TNF-α. The TRAF1/TRAF2 complex recruits BIRC2 and BIRC3 to TNFRSF1B/TNFR2 to regulate the apoptotic pathway. TNFRII Protein, Human (183a.a) is the recombinant human-derived TNFRII protein, expressed by E. coli , with tag free.

HY-P70536

	TNF RII/TNFRSF1B Protein, Human (183a.a, HEK293, mFc) TNF-RII; TNFRII; TNF RII; Tumor necrosis factor receptor superfamily member 1B; TNFRSF1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor; CD120b	Human	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNF RII/TNFRSF1B Protein, Human (183a.a, HEK293, mFc) is expressed by HEK293 and has a transmembrane region (P24-T206) with mFc tag at the C-terminus.

HY-P76311

	ECSIT Protein, Human (His) Evolutionarily conserved signalIng Intermediate In Toll pathway, mitochondrial; ProteIn SITPEC; ECSIT	Human	E. coli
	ECSIT protein is an adapter protein in Toll-like receptors, IL-1, and antiviral signaling that crucially activates NF-kappa-B by complexing with TRAF6 and TAK1/MAP3K7, leading to TAK1/MAP3K7 activation and subsequent IKK activation. Ubiquitinated ECSIT interacts with RELA and NFKB1 and translocates to induce NF-kappa-B-dependent gene expression. ECSIT Protein, Human (His) is the recombinant human-derived ECSIT protein, expressed by E. coli , with N-His labeled tag.

HY-P71260

	RHEB Protein, Human (GST) GTP-BIndIng ProteIn Rheb; Ras Homolog Enriched In BraIn; RHEB; RHEB2	Human	E. coli
	RHEB is an important small GTPase that acts as an allosteric activator of the mTORC1 complex, a key nutrient sensor that controls cell growth and biomass production. In response to signals such as nutrients and growth factors, RHEB activates the MTOR kinase within mTORC1 by inducing conformational changes. RHEB Protein, Human (GST) is the recombinant human-derived RHEB protein, expressed by E. coli , with N-GST labeled tag.

HY-P71195

	PEA15 Protein, Human Astrocytic PhosphoproteIn PEA-15; 15 kDa PhosphoproteIn Enriched In Astrocytes; PhosphoproteIn Enriched In Diabetes; PED; PEA15	Human	E. coli
	The PEA15 protein is a regulator of multiple cellular processes that blocks Ras-mediated integrin inhibition and modulates the ERK MAP kinase cascade. It inhibits RPS6KA3 activity by sequestering RPS6KA3 in the cytoplasm, regulating key cellular pathways. PEA15 Protein, Human is the recombinant human-derived PEA15 protein, expressed by E. coli , with tag free.

HY-P701853

	APC Protein, Human (His) APC; Adenomatous polyposis coli proteIn; ProteIn APC; Deleted In polyposis 2.5	Human	E. coli
	The APC protein is a multifaceted tumor suppressor that rapidly degrades CTNNB1 and acts as a negative regulator in the Wnt pathway. Its phosphorylation status intricately affects activity. APC Protein, Human (His) is the recombinant human-derived APC protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702186

	AIM2 Protein, Human AIM2; Interferon-Inducible proteIn AIM2; Absent In melanoma 2	Human	E. coli
	AIM2 protein is a key sensor in the AIM2 inflammasome, which can activate the inflammasome in response to cytoplasmic dsDNA, thereby inducing pyroptosis. This complex is triggered by pathogens or injury signals and plays a critical role in innate immunity and inflammation. AIM2 Protein, Human is the recombinant human-derived AIM2 protein, expressed by E. coli , with tag free.

HY-P73420

	SPARC Protein, Rat (HEK293, His) SPARC; BM-40; OsteonectIn; ON; Secreted ProteIn Acidic and Rich In CysteIne	Rat	HEK293
	SPARC protein is involved in the regulation of cell growth and may play a regulatory role by affecting the interaction of extracellular matrix and cytokines. SPRC protein can bind calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. It has two calcium binding sites: one is an acidic domain that can bind 5-8 Ca²⁺ with low affinity, and the other is an EF-hand loop that can bind Ca²⁺ ions with high affinity. SPARC Protein, Rat (HEK293, His) is the recombinant rat-derived SPARC protein, expressed by HEK293 , with C-His labeled tag.

HY-P702187

	AIM2 Protein, Human (His) AIM2; Interferon-Inducible proteIn AIM2; Absent In melanoma 2	Human	E. coli
	AIM2 protein is a key sensor in the AIM2 inflammasome, which can activate the inflammasome in response to cytoplasmic dsDNA, thereby inducing pyroptosis. This complex is triggered by pathogens or injury signals and plays a critical role in innate immunity and inflammation. AIM2 Protein, Human (His) is the recombinant human-derived AIM2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P700268

	RHEB Protein, Human (sf9, N-His) GTP-BIndIng ProteIn Rheb; Ras Homolog Enriched In BraIn; RHEB; RHEB2	Human	Sf9 insect cells
	RHEB is an important small GTPase that acts as an allosteric activator of the mTORC1 complex, a key nutrient sensor that controls cell growth and biomass production. In response to signals such as nutrients and growth factors, RHEB activates the MTOR kinase within mTORC1 by inducing conformational changes. RHEB Protein, Human (sf9, N-His) is the recombinant human-derived RHEB protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P72816

	AIM2 Protein, Human (sf9, GST) Interferon-Inducible proteIn AIM2; Absent In melanoma 2; AIM2	Human	Sf9 insect cells
	AIM2 Protein, a member of the IFI20X/IFI16 family, exhibits potential regulatory functions in cell proliferation and tumorigenic reversion. Induced by interferon-gamma, AIM2 plays a key role in immune responses. Notably expressed in tissues like lymph node and appendix, AIM2 is a significant player in diverse cellular processes and immune-related functions. AIM2 Protein, Human (sf9, GST) is the recombinant human-derived AIM2 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P71184

	PACSIN2 Protein, Human (HEK293, His) ProteIn KInase C and CaseIn KInase Substrate In Neurons ProteIn 2; PACSIn2	Human	HEK293
	The PACSIN2 protein coordinates caveolar morphogenesis and endocytosis to dynamically regulate cell membrane structure. As a lipid-binding protein, PACSIN2 regulates phosphatidic acid-containing membranes. PACSIN2 Protein, Human (HEK293, His) is the recombinant human-derived PACSIN2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P704110

	Mucin-13 Protein, Human (HEK293, His) MUC13; MucIn-13; Down-regulated In colon cancer 1; DRCC1; RECC	Human	HEK293
	Mucin-13 Protein, Human (HEK293, His) is the recombinant human-derived Mucin-13 protein, expressed by HEK293, with C-10*His tag.

HY-P71588

	CHD1L Protein, Human (His-SUMO) ALC1; Amplified In liver cancer 1; Amplified In liver cancer proteIn 1; chd1l; CHD1L_HUMAN; CHDL; ChromodomaIn helicase DNA bIndIng proteIn 1 like; ChromodomaIn-helicase-DNA-bIndIng proteIn 1-like; FLJ22530	Human	E. coli
	CHD1L protein is the ATP-binding subunit of the mitochondrial potassium channel and cooperates with CCDC51/MITOK to form a complex to promote ATP-dependent potassium current across the inner membrane (mitoK(ATP) channel). ABCB8 is essential for mitochondrial iron transport, affects cardiac function, and regulates the maturation of cytosolic iron-sulfur-containing enzymes. CHD1L Protein, Human (His-SUMO) is the recombinant human-derived CHD1L protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

HY-P71258

	RELT Protein, Human (HEK293, Fc) Tumor necrosis factor receptor superfamily member 19L; TNFRSF19L; Receptor expressed In lymphoid tissues; RELT	Human	HEK293
	RELT protein may play a role in apoptosis, suggesting its involvement in the complex cellular process of programmed cell death. When overexpressed, RELT activates the MAPK14/p38 and MAPK8/JNK MAPK cascades, affecting key signaling pathways. RELT Protein, Human (HEK293, Fc) is the recombinant human-derived RELT protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P71183

	PACSIN1 Protein, Human (HEK293, His) ProteIn KInase C and CaseIn KInase Substrate In Neurons ProteIn 1; PACSIn1; KIAA1379	Human	HEK293
	The PACSIN1 protein has multiple functions in cell dynamics, reorganizing microtubules and the actin cytoskeleton. PACSIN1 interacts with MAPT, reduces microtubule stability and inhibits MAPT-induced polymerization. PACSIN1 Protein, Human (HEK293, His) is the recombinant human-derived PACSIN1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P73526

	Serpin G1 Protein, Human (HEK293, His) 1 Publications Verification C1In; C1InH; SERPInG1; SerpIn G1; Plasma protease C1 Inhibitor	Human	HEK293
	Serpin G1, also known as C1 inhibitor, controls C1 complex activation by forming a proteolytically inactive complex with C1r or C1s proteases. Their interactions regulate physiological pathways such as complement activation, coagulation, fibrinolysis, and kinin production. Serpin G1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin G1 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P73654

	Serpin G1 Protein, Rat (HEK293, His) C1In; C1InH; SERPInG1; SerpIn G1; Plasma protease C1 Inhibitor	Rat	HEK293
	Serpin G1 protein binds complement and inhibits serine-type endopeptidases. It is located in the extracellular space and is involved in aging. Serpin G1 Protein, Rat (HEK293, His) is the recombinant rat-derived Serpin G1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P702630

	FUS Protein, Human (His, Myc) RNA-bIndIng proteIn FUS; 75 kDa DNA-pairIng proteIn; Oncogene FUS; Oncogene TLS; POMp75; Translocated In liposarcoma proteIn; TLS	Human	E. coli
	FUS Protein, Human (His, Myc) is the recombinant human-derived FUS, expressed by E. coli , with N-10*His, C-Myc labeled tag.

HY-P704622

	FUS Protein, Human (MBP-His) RNA-bIndIng proteIn FUS; 75 kDa DNA-pairIng proteIn; Oncogene FUS; Oncogene TLS; POMp75; Translocated In liposarcoma proteIn; TLS	Human	E. coli
	FUS Protein, Human (MBP-His) is the recombinant human-derived FUS protein, expressed by E. coli, with N-His & N-MBP tag.

HY-P71094

	SPARC Protein, Human (HEK293, His) 1 Publications Verification SPARC; Basement-Membrane ProteIn 40; BM-40; OsteonectIn; ON; Secreted ProteIn Acidic and Rich In CysteIne; SPARC; ON	Human	HEK293
	SPARC proteins are essential for lipid transport and are involved in the production, transformation, and clearance of plasma lipoproteins. It interacts with different particles, shows a preference for HDL, and binds to cellular receptors such as LDLR and VLDLR to promote the uptake of APOE-containing lipoproteins. SPARC Protein, Human (HEK293, His) is the recombinant human-derived SPARC protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P75710

	DMBT1 Protein, Human (HEK293, His) Deleted In malignant braIn tumors 1 proteIn; GlycoproteIn 340; Gp-340; HensIn; SAG; DMBT1	Human	HEK293
	The DMBT1 protein is a potential tumor suppressor in a variety of cancers and affects a variety of biological processes. It contributes to mucosal and cellular immune defense, epithelial differentiation, and serves as an opsonin receptor for SFTPD and SPAR in macrophages. DMBT1 Protein, Human (HEK293, His) is the recombinant human-derived DMBT1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70935

	EPDR1 Protein, Human (HEK293, His) Mammalian ependymIn-related proteIn 1; EPDR1; Upregulated In colorectal cancer gene 1 proteIn; MERP1	Human	HEK293
	In the rat model, the EPDR1 protein plays a key regulator role by binding to and activating the TIE2 receptor, initiating its tyrosine phosphorylation. This interaction affects processes of endothelial development that are distinct from the effects of VEGF, which mediates interactions between the endothelium and the surrounding matrix and interstitium. EPDR1 Protein, Human (HEK293, His) is the recombinant human-derived EPDR1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71124

	NFKB1 Protein, Human (His) DNA-bIndIng factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer In B-cells 1	Human	E. coli
	The NFKB1 protein is a subunit of NF-kappa-B and regulates transcription in a variety of biological processes. It forms homodimeric or heterodimeric complexes with RELA/p65, RELB, and NFKB2/p52. NFKB1 Protein, Human (His) is the recombinant human-derived NFKB1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701711

	BMX Protein, Human (sf9) BMX; Cytoplasmic tyrosIne-proteIn kInase BMX; Bone marrow tyrosIne kInase gene In chromosome X proteIn; Epithelial and endothelial tyrosIne kInase; ETK; NTK38	Human	Sf9 insect cells
	BMX proteins are nonreceptor tyrosine kinases that centrally regulate various signaling pathways that control actin dynamics, migration, proliferation, and survival. BMX participates in signal transduction of multiple receptors such as integrins, growth factor receptors, and cytokine receptors, induces BCAR1 tyrosine phosphorylation, and plays a key role in TNF-induced angiogenesis. BMX Protein, Human (sf9) is the recombinant human-derived BMX protein, expressed by sf9 insect cells , with tag free.

HY-P701712

	BMX Protein, Human (sf9, His) BMX; Cytoplasmic tyrosIne-proteIn kInase BMX; Bone marrow tyrosIne kInase gene In chromosome X proteIn; Epithelial and endothelial tyrosIne kInase; ETK; NTK38	Human	Sf9 insect cells
	BMX proteins are nonreceptor tyrosine kinases that centrally regulate various signaling pathways that control actin dynamics, migration, proliferation, and survival. BMX participates in signal transduction of multiple receptors such as integrins, growth factor receptors, and cytokine receptors, induces BCAR1 tyrosine phosphorylation, and plays a key role in TNF-induced angiogenesis. BMX Protein, Human (sf9, His) is the recombinant human-derived BMX protein, expressed by sf9 insect cells , with N-8*His labeled tag.

HY-P701764

	RCK Protein, Human (His) MAP3K19; Mitogen-activated proteIn kInase kInase kInase 19; Regulated In COPD; proteIn kInase; SPS1/STE20-related proteIn kInase YSK4	Human	E. coli
	MAP3K19 is a protein kinase involved in intracellular signaling. MAP3K19 can directly activate the ERK and JNK pathways and plays an important role in maintaining the survival of KRAS-mutant lung cancer cells. In addition, MAP3K19 also regulates allergic airway inflammation in patients with asthma by inhibiting airway epithelial responses stimulated by TWEAK, including reduced adhesion factors and production of RANTES, and suppressing allergic airway inflammation in a mouse model of asthma. RCK Protein, Human (His) is the recombinant human-derived RCK protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70142

	Spondin-2/SPON2 Protein, Human (HEK293, His) 1 Publications Verification rHuSpondIn-2/SPON2, His; SpondIn-2; Differentially expressed In cancerous and non-cancerous lung cells 1; DIL-1; MIndIn; SPON2	Human	HEK293
	Spondin-2 protein is a matricellular protein with antigen binding, lipopolysaccharide binding and metal ion binding activity. Spondin-2 is essential for recruiting lymphocytes and initiating immune responses while being involved in cell adhesion, defense response to other organism; opsonization; and positive regulation of cytokine production. Spondin-2 is found to promote infiltration of M1-like macrophages and inhibits tumor metastasis in cancer research. Spondin-2/SPON2 Protein, Human (HEK293, His) is the recombinant human-derived Spondin-2/SPON2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P700966

	CD44 Protein, Human (242a.a, HEK293, hFc) CD44; CDw44; Epican; ECMR-III; LHR; MDU2; MDU3; MIC4; PGP-I; CSPG8; HCELL; HUTCH-I; In; MC56	Human	HEK293
	CD44 is a cell surface receptor that plays a key role in calcium mobilization and actin-mediated cytoskeletal reorganization, cell migration, and adhesion. CD44 Protein, Human (242a.a, HEK293, hFc) is a recombinant protein dimer complex containing human-derived CD44 protein, expressed by HEK293 , with C-hFc labeled tag. CD44 Protein, Human (242a.a, HEK293, hFc), has molecular weight of 70-100 kDa.

HY-P700967

	CD44 Protein, Human (242a.a, HEK293, His) CD44; CDw44; Epican; ECMR-III; LHR; MDU2; MDU3; MIC4; PGP-I; CSPG8; HCELL; HUTCH-I; In; MC56	Human	HEK293
	CD44 is a cell surface receptor that plays a key role in calcium mobilization and actin-mediated cytoskeletal reorganization, cell migration, and adhesion. CD44 Protein, Human (242a.a, HEK293, His) is the recombinant human-derived CD44 protein, expressed by HEK293, with C-His labeled tag.

HY-P701825

	NEK6 Protein, Human (sf9, GST) NEK6; SerIne/threonIne-proteIn kInase Nek6; Never In mitosis A-related kInase 6; NimA-related proteIn kInase 6; ProteIn kInase SID6-1512	Human	Sf9 insect cells
	The NEK6 protein is a key kinase essential for driving mitotic cell cycle progression, ensuring chromosome segregation, robust spindle formation, and cytokinesis. It phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histone H1/H3, affecting a variety of cellular processes. NEK6 Protein, Human (sf9, GST) is the recombinant human-derived NEK6 protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P72226

	HJURP Protein, Human (His-SUMO) HJURP; FAKTS; FLEG1; URLC9; Holliday junction recognition proteIn; 14-3-3-associated AKT substrate; Fetal liver-expressIng gene 1 proteIn; Up-regulated In lung cancer 9	Human	E. coli
	The HJURP protein is a centromeric factor that plays a critical role in centromeric integration and maintenance of CENPA. As a chaperone, it ensures the integration of newly synthesized CENPA into nucleosomes at replicating centromeres. HJURP Protein, Human (His-SUMO) is the recombinant human-derived HJURP protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P70142A

	Spondin-2/SPON2 Protein, Human (Q9BUD6, HEK293, His) rHuSpondIn-2/SPON2, His; SpondIn-2; Differentially expressed In cancerous and non-cancerous lung cells 1; DIL-1; MIndIn; SPON2	Human	HEK293
	Spondin-2/SPON2 protein, as a cell adhesion molecule, plays a key role in promoting the adhesion and growth of hippocampal embryonic neurons.In addition to its role in neurodevelopment, SPON2 acts as a direct binder of bacteria and their components, functioning as an opsonin to promote phagocytosis of bacteria by macrophages.Spondin-2/SPON2 Protein, Human (Q9BUD6, HEK293, His) is the recombinant human-derived Spondin-2/SPON2 protein, expressed by HEK293 , with His labeled tag.

HY-P71940A

	ARMET/MANF Protein, Human (His) 1 Publications Verification ArgInIne rich mutated In early stage tumors; ArgInIne rich proteIn; ArgInIne-rich proteIn; ARMET; ARMET proteIn; ARP; Manf; MANF_HUMAN; Mesencephalic astrocyte derived neurotrophic factor; Mesencephalic astrocyte-derived neurotrophic factor; MGC142148; MGC142150; ProteIn ARMET	Human	E. coli
	ARMET/MANF proteins critically support the survival of dopaminergic neurons in the ventral midbrain and contribute to neuronal homeostasis. It modulates GABAergic transmission and enhances inhibitory postsynaptic currents in substantia nigra dopaminergic neurons. ARMET/MANF Protein, Human (His) is the recombinant human-derived ARMET/MANF protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701686

	FIP1L1 Protein, Human (sf9, His, GST) FIP1L1; Pre-mRNA 3'-end-processIng factor FIP1; hFip1; FIP1-like 1 proteIn; Factor InteractIng with PAP; Rearranged In hypereosInophilia	Human	Sf9 insect cells
	The FIP1L1 protein is an important component of the CPSF complex and is responsible for the formation of the 3' end of pre-mRNA. FIP1L1 Protein, Human (sf9, His, GST) is the recombinant human-derived FIP1L1 protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.

HY-P701823

	NEK2 Protein, Human (T175A, His) NEK2; SerIne/threonIne-proteIn kInase Nek2; HSPK 21; Never In mitosis A-related kInase 2; NimA-related proteIn kInase 2; NimA-like proteIn kInase 1	Human	E. coli
	The NEK2 protein is a key kinase that coordinates important events in cell division and chromatin dynamics. In mitotic cells, it critically controls centrosome separation and bipolar spindle formation by phosphorylating CROCC, CEP250 and NINL. NEK2 Protein, Human (T175A, His) is the recombinant human-derived NEK2 protein, expressed by E. coli , with N-6*His labeled tag and T175A mutation.

HY-P701827

	NEK9 Protein, Human (sf9, GST) NEK9; SerIne/threonIne-proteIn kInase Nek9; Nercc1 kInase; Never In mitosis A-related kInase 9; NimA-related proteIn kInase 9; NimA-related kInase 8; Nek8	Human	Sf9 insect cells
	The NEK9 protein is a pleiotropic mitotic regulator that oversees spindle dynamics and chromosome segregation. It phosphorylates a variety of substrates, including histones, myelin basic protein, β-casein, and BICD2. NEK9 Protein, Human (sf9, GST) is the recombinant human-derived NEK9 protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P701822

	NEK2 Protein, Human (T175A) NEK2; SerIne/threonIne-proteIn kInase Nek2; HSPK 21; Never In mitosis A-related kInase 2; NimA-related proteIn kInase 2; NimA-like proteIn kInase 1	Human	E. coli
	The NEK2 protein is a key kinase that coordinates important events in cell division and chromatin dynamics. In mitotic cells, it critically controls centrosome separation and bipolar spindle formation by phosphorylating CROCC, CEP250 and NINL. NEK2 Protein, Human is the recombinant human-derived NEK2 protein, expressed by E. coli , with tag free, and T175A mutation.

HY-P71202

	PHLDA2 Protein, Human (His) PleckstrIn Homology-Like DomaIn Family A Member 2; Beckwith-Wiedemann Syndrome Chromosomal Region 1 Candidate Gene C ProteIn; ImprInted In Placenta and Liver ProteIn; Tumor-SuppressIng STF cDNA 3 ProteIn; Tumor-SuppressIng Subchromosomal Transferable Fragment	Human	E. coli
	PHLDA2 protein regulates placenta growth, potentially through its PH domain, which competes with other PH domain-containing proteins, hindering their binding to membrane lipids. PHLDA2 Protein, Human (His) is the recombinant human-derived PHLDA2 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P701431

	USP9X Protein, Human (GST) USP9X; Probable ubiquitIn carboxyl-termInal hydrolase FAF-X; DeubiquitInatIng enzyme FAF-X; Fat facets In mammals; hFAM; Fat facets proteIn-related; X-lInked; UbiquitIn thioesterase FAF-X; UbiquitIn-specific protease 9; X chromosome; UbiquitIn-specific-processIng protease FAF-X	Human	E. coli
	The USP9X protein serves as a deubiquitinase, playing a crucial role in processing ubiquitin precursors and preventing protein degradation. It exhibits specificity in hydrolyzing various polyubiquitin chain linkages, including "Lys-63", "Lys-48", "Lys-29" and "Lys-33". USP9X Protein, Human (GST) is the recombinant human-derived USP9X protein, expressed by E. coli , with N-GST labeled tag.

HY-P701432

	USP9X Protein, Human USP9X; Probable ubiquitIn carboxyl-termInal hydrolase FAF-X; DeubiquitInatIng enzyme FAF-X; Fat facets In mammals; hFAM; Fat facets proteIn-related; X-lInked; UbiquitIn thioesterase FAF-X; UbiquitIn-specific protease 9; X chromosome; UbiquitIn-specific-processIng protease FAF-X	Human	E. coli
	The USP9X protein serves as a deubiquitinase, playing a crucial role in processing ubiquitin precursors and preventing protein degradation. It exhibits specificity in hydrolyzing various polyubiquitin chain linkages, including "Lys-63", "Lys-48", "Lys-29" and "Lys-33". USP9X Protein, Human is the recombinant human-derived USP9X protein, expressed by E. coli , with tag free.

HY-P702739

	NEK2 Protein, Human (Active) NEK2; NIMA (never In mitosis gene a)-related kInase 2; serIne/threonIne-proteIn kInase Nek2; HsPK 21; NEK2A; NLK1; nimA-like proteIn kInase 1; nimA-related proteIn kInase 2; HsPK21	Human	E. coli
	The NEK2 protein is a key kinase that coordinates important events in cell division and chromatin dynamics. In mitotic cells, it critically controls centrosome separation and bipolar spindle formation by phosphorylating CROCC, CEP250 and NINL. NEK2 Protein, Human (Active) is the recombinant human-derived NEK2, expressed by E. coli , with tag Free labeled tag. ,

HY-P70469

	SDF-1 alpha/CXCL12 Protein, Human 1 Publications Verification Stromal Cell-Derived Factor 1; SDF-1; hSDF-1; C-X-C Motif ChemokIne 12; IntercrIne Reduced In Hepatomas; IRH; hIRH; Pre-B Cell Growth-StimulatIng Factor; PBSF; CXCL12; SDF1; SDF1A; SDF1B	Human	E. coli
	SDF-1 alpha (CXCL12α) belongs to the CXC chemokine family and is encoded by the CXCL12 gene. SDF-1 alpha mediates cell chemotaxis and tissue repair through CXCR4/CXCR7, activates AMPK to inhibit NLRP3 inflammasome and pyroptosis; SDF-1 alpha promotes autophagy through the PI3K-mTOR pathway, is induced by upstream inflammatory factors such as TNF-α, and recruits integrins downstream to promote cell adhesion. SDF-1 alpha/CXCL12 Protein, Human is the recombinant human-derived SDF-1 alpha/CXCL12 protein, expressed by E. coli, with tag free.

HY-P71324

	SMAD4 Protein, Human (His) Mothers AgaInst Decapentaplegic Homolog 4; MAD Homolog 4; Mothers AgaInst DPP Homolog 4; Deletion Target In Pancreatic CarcInoma 4; SMAD Family Member 4; SMAD 4; Smad4; hSMAD4; SMAD4; DPC4; MADH4	Human	E. coli
	SMAD4 is a class of common mediator SMAD (Co-SMAD), which belongs to the dwarfin/SMAD family. It conducts cell signals through the SMAD4/TGF-β pathway and plays an important role in promoting bone development and tissue homeostasis. SMAD4 induces chondrogenesis of human bone marrow mesenchymal stem cells, and specifically targets stem cells to participate in self-renewal of hematopoietic stem cells. SMAD4 can also protect cell apoptosis and inhibit epithelial cell proliferation, showing antitumor effects. SMAD4 Protein, Human (His) has the 552 a.a. sequence (M1-D552), produced in E.coli with C-terminal 6*His-tag.

HY-P71270

	S100A12 Protein, Human ProteIn S100-A12; Calcium-bIndIng proteIn In amniotic fluid 1; CalgranulIn-C; Extracellular newly identified RAGE-bIndIng proteIn; Migration Inhibitory factor-related proteIn 6; S100 calcium-bIndIng proteIn A12; CalcitermIn; S100A12; CGRP; MRP-6; EN-RAGE	Human	E. coli
	The S100A12 protein is a calcium, zinc, and copper binder that regulates inflammation and immune responses. As a DAMP molecule, it activates innate immune cells through AGER, triggering pro-inflammatory pathways. S100A12 Protein, Human is the recombinant human-derived S100A12 protein, expressed by E. coli , with tag free.

HY-P700118AF

	Animal-Free IL-27 beta/EBI3 Protein, Human (His) InterleukIn-27 subunit alpha; IL-27-A; InterleukIn-27 subunit beta; IL-27B; EpsteIn-Barr virus-In_x0002_duced gene 3 proteIn; EBV-Induced gene 3 proteIn; EBI3; p28; InterleukIn-30; IL-30	Human	E. coli
	The IL-27 beta/EBI3 protein binds to IL27 to form IL-27 interleukin, which is critical in innate immunity. IL-27 has both pro- and anti-inflammatory properties, regulating T helper cell development, inhibiting T cell proliferation, stimulating cytotoxic T cell activity, inducing B cell isotype switching, and affecting innate immune cells. Animal-Free IL-27 beta/EBI3 Protein, Human (His) is the recombinant human-derived animal-FreeIL-27 beta/EBI3 protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P70085

	CADM1/IGSF4A Protein, Mouse (HEK293, His) rMuCell adhesion molecule 1/CADM1, His; Cell adhesion molecule 1; ImmunoglobulIn superfamily member 4; IgSF4; NectIn-like proteIn 2; NECL-2; Synaptic cell adhesion molecule; SynCAM; Tumor suppressor In lung cancer 1; TSLC-1	Mouse	HEK293
	CADM1/IGSF4A proteins coordinate Ca(2+)-independent homophilic and heterophilic cell adhesion with CADM3 and NECTIN3. Interaction with CRTAM enhances NK cell cytotoxicity and CD8+ T cell function. CADM1/IGSF4A Protein, Mouse (341a.a, HEK293, His) is the recombinant mouse-derived CADM1/IGSF4A protein, expressed by HEK293 , with C-6*His labeled tag.

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HY-P80915

	TNF Receptor 2 Antibody CD120b; p75 TNF receptor; p80 TNF alpha receptor; Soluble TNFR1B variant 1; TBP-2; TBPII; TNF R75; TNFBR; TNFR-II; TNFR1B; TNFR2; TNFR80; TNFRII; Tnfrsf1b	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat
	TNF Receptor 2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to TNF Receptor 2.

HY-P80088

	Cortactin Antibody (YA495) AmplaxIn antibody; CTTN antibody; EMS 1 antibody; EMS1 antibody; FLJ34459 antibody; Mammary tumor and squamous cell carcInoma associated antibody; Oncogene EMS1 antibody; p80/85 src substrate antibody; Src substrate cortactIn antibody; SRC8_HUMAN antibody	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
	Cortactin Antibody (YA495) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cortactin.

HY-P82689

	XPD Antibody (YA2434) BTF2 p80; COFS2; CXPD; EM9; ERCC2; MAG; TFIIH p80; TTD; XPD; XPDC	WB, ICC/IF	Human
	XPD Antibody (YA2434) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to XPD.

HY-P82787

	Coilin Antibody (YA2532) CLN80; COIL; CoilIn; CoilIn p80	WB	Human
	Coilin Antibody (YA2532) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Coilin.

HY-P84100

	IL1R1 Antibody (YA3797) p80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha	WB, FC, ELISA	Human
	IL1R1 Antibody (YA3797) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL1R1.

HY-P84879

	*ALK/p80* Antibody (YA4576)** CD246; NBLST3	WB, FC, ELISA	Human
	ALK/p80 Antibody (YA4576) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ALK/p80.

HY-P84880

	*ALK/p80* Antibody (YA4577)** CD246; NBLST3	WB, IHC-P, FC, ELISA	Human
	ALK/p80 Antibody (YA4577) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ALK/p80.

HY-P86369

	*ALK/p80* Antibody (YA6061)** ALK; ALK tyrosIne kInase receptor; Anaplastic lymphoma kInase; CD antigen CD246	WB, IHC-P, ICC/IF, IP, ELISA	Human
	ALK/p80 Antibody (YA6061) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ALK/p80.

HY-P82901

	DAZAP1 Antibody (YA2646) Deleted In azoospermia-associated proteIn 1	WB, IP	Human, Mouse, Rat
	DAZAP1 Antibody (YA2646) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DAZAP1.

HY-P86253

	NABC1 Antibody (YA5945) BCAS1; AIBC1; NABC1; Breast carcInoma-amplified sequence 1 ; Amplified and overexpressed In breast cancer; Novel amplified In breast cancer 1;	WB	Human
	NABC1 Antibody (YA5945) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NABC1.

HY-P85490

	DBC 1 Antibody (YA5182) DBCCR1; Deleted In bladder cancer proteIn 1; Deleted In bladder cancer proteIn 1 recursor; FAM5A; ProteIn FAM5A.	WB, ICC/IF, IP	Human, Mouse, Rat, Monkey
	DBC 1 Antibody (YA5182) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to DBC 1.

HY-P85605

	XRCC1 Antibody (YA5297) DNA repair proteIn XRCC1; RCC; X ray repair complementIng defective repair In chInese hamster; X ray repair complementIng defective repair In chInese hamster cells 1; X ray Repair ComplementIng Defective Repair In ChInese Hamster Cells; X ray repair cross complementIng proteIn 1; X ray repair, complementIng defective, repair In ChInese hamster; X-ray repair cross-complementIng proteIn 1; XRCC 1; Xrcc1; XRCC1_HUMAN.	WB	Human
	XRCC1 Antibody (YA5297) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to XRCC1.

HY-P81285

	LPP Antibody (YA993) LPP; Lipoma-preferred partner; LIM domaIn-contaInIng preferred translocation partner In lipoma	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Monkey, Hamster
	LPP Antibody (YA993) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LPP.

HY-P81285A

	LPP Antibody (YA994) LPP; Lipoma-preferred partner; LIM domaIn-contaInIng preferred translocation partner In lipoma	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	LPP Antibody (YA994) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LPP.

HY-P85263

	LPP Antibody (YA4955) LPP; Lipoma-preferred partner; LIM domaIn-contaInIng preferred translocation partner In lipoma	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Monkey, Hamster
	LPP Antibody (YA4955) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to LPP.

HY-P81419

	Claudin 5 Antibody (YA1164) CLDN5; AWAL; TMVCF; ClaudIn-5; Transmembrane proteIn deleted In VCFS; TMDVCF	IHC-P	Human
	Claudin 5 Antibody (YA1164) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 5.

HY-P84122

	CD44 Antibody (YA3819) In; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
	CD44 Antibody (YA3819) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD44.

HY-P86997

	Nutm1 Antibody (YA6690) NUT family member 1 antibody; Nuclear proteIn In testis antibody; Nutm1 antibody; Nut antibody;	WB, IHC-P, ICC/IF, IF-Tissue	Human, Mouse, Rat
	Nutm1 Antibody (YA6690) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nutm1.

HY-P87277

	INCENP Antibody (YA6960) bInds and activates aurora B and C In vivo and In vitro antibody; Chromosomal passenger proteIn antibody; InCE_HUMAN antibody; InCENP antibody; Inner centromere proteIn antibody; Inner centromere proteIn antigens 135/155kDa antibody; Inner centromere proteIn antigens 135kD 155kD antibody; Inner centromere proteIn InCENP antibody	ICC/IF, IHC-P, FC	Human
	INCENP Antibody (YA6960) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to INCENP.

HY-P81457

	SPARC Antibody (YA1202) SPARC; ON; SPARC; Basement-membrane proteIn 40; BM-40; OsteonectIn; ON; Secreted proteIn acidic and rich In cysteIne	IHC-P	Human
	SPARC Antibody (YA1202) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SPARC.

HY-P83452

	TLS/FUS Antibody (YA3197) FUS; FUS-CHOP; TLS; 75 kDa DNA-pairIng proteIn; Oncogene FUS; Oncogene TLS; POMP75; Translocated In liposarcoma proteIn	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	TLS/FUS Antibody (YA3197) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TLS/FUS.

HY-P86845

	DCC Antibody (YA6538) Colorectal cancer related chromosome sequence 18 antibody; Colorectal cancer suppressor antibody; CRC 18 antibody; CRC18 antibody; CRCR 1 antibody; CRCR1 antibody; DCC antibody; DCC_HUMAN antibody; Deleted In colorectal cancer proteIn antibody; Deleted In colorectal carcInoma antibody; Colorectal cancer related chromosome sequence 18 antibody; Colorectal cancer suppressor antibody; CRC 18 antibody; CRC18 antibody; CRCR 1 antibody; CRCR1 antibody; DCC antibody; DCC_HUMAN antibody; Deleted In colorectal cancer proteIn antibody; Deleted In colorectal carcInoma antibody; ImmunoglobulIn superfamily DCC subclass member 1 antibody; NetrIn receptor DCC antibody; Tumor suppressor proteIn DCC antibody;	WB, IHC-F	Human, Mouse, Rat
	DCC Antibody (YA6538) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DCC.

HY-P85429

	FoxO1 Antibody (YA5121) FOXO1; FKHR; FOXO1A; Forkhead box proteIn O1; Forkhead box proteIn O1A; Forkhead In rhabdomyosarcoma	WB, ICC/IF	Human, Mouse
	FoxO1 Antibody (YA5121) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FoxO1.

HY-P86588

	FOXO1 Antibody (YA6280) FOXO1; FKHR; FOXO1A; Forkhead box proteIn O1; Forkhead box proteIn O1A; Forkhead In rhabdomyosarcoma	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse,
	FOXO1 Antibody (YA6280) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXO1.

HY-P81074

	FOXO1/FOXO1A Antibody FOXO1; FKHR; FOXO1A; Forkhead box proteIn O1; Forkhead box proteIn O1A; Forkhead In rhabdomyosarcoma	WB, IHC-F, IHC-P, ICC/IF, ELISA, ChIP	Human, Mouse, Rat, Pig
	FOXO1/FOXO1A Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to FOXO1/FOXO1A.

HY-P85063

	ETK Antibody (YA4755) BMX; Cytoplasmic tyrosIne-proteIn kInase BMX; Bone marrow tyrosIne kInase gene In chromosome X proteIn; Epithelial and endothelial tyrosIne kInase; ETK; NTK38	WB, ELISA	Human
	ETK Antibody (YA4755) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ETK.

HY-P85530

	IKK beta Antibody (YA5222) I kappa B kInase 2; I kappa B kInase beta; I-kappa-B kInase 2; I-kappa-B-kInase beta; IkBKB; IKK 2; IKK B; IKK beta; IKK-B; IKK-beta; IKK2; IKKB; IKKB_HUMAN; IMD15; Inhibitor of kappa light chaIn gene enhancer In B cells; Inhibitor of kappa light polypeptide gene enhancer In B cells; Inhibitor of kappa light polypeptide gene enhancer In B cells kInase beta; Inhibitor of kappa light polypeptide gene enhancer In B cells, kInase beta; Inhibitor of nuclear factor kappa B kInase beta subunit; Inhibitor of nuclear factor kappa B kInase subunit beta; Inhibitor of nuclear factor kappa-B kInase subunit beta; MGC131801; NFKBIKB; Nuclear factor NF kappa B Inhibitor kInase beta; Nuclear factor NF-kappa-B Inhibitor kInase beta; Nuclear factor of kappa light chaIn gene enhancer In B cells Inhibitor.	WB	Human, Rat
	IKK beta Antibody (YA5222) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IKK beta.

HY-P87272

	SIAH1 Antibody (YA6955) E3 ubiquitIn-proteIn ligase SIAH1 antibody; FLJ08065 antibody; hSIAH1 antibody; HUMSIAH antibody; Seven In absentia homolog 1 (Drosophila) antibody; Seven In absentia homolog 1 antibody; Siah 1 antibody; Siah 1a antibody; Siah E3 ubiquitIn proteIn ligase 1 antibody; Siah-1 antibody	WB, ICC/IF	Human, Mouse, Rat
	SIAH1 Antibody (YA6955) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SIAH1.

HY-P80676

	FOXO1/FOXO1A Antibody (YA430) FOXO1; FKHR; FOXO1A; Forkhead box proteIn O1; Forkhead box proteIn O1A; Forkhead In rhabdomyosarcoma	WB, IHC-F, IHC-P, ICC/IF	Human
	FOXO1/FOXO1A Antibody (YA430) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXO1/FOXO1A.

HY-P81481

	DMRT1 Antibody (YA1226) DMT1; DMRT1; DM domaIn expressed In testis proteIn 1; Doublesex- and mab-3-related transcription factor 1	IHC-P	Human
	DMRT1 Antibody (YA1226) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DMRT1.

HY-P86280

	PACSIN3 Antibody (YA5972) PACSIn3; ProteIn kInase C and caseIn kInase substrate In neurons proteIn 3 ; SH3 domaIn-contaInIng proteIn 6511;	WB, IHC-P, ICC/IF, FC, IP	Human
	PACSIN3 Antibody (YA5972) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PACSIN3.

HY-P85525

	FOXO1(C-term) Antibody (YA5217) FKH 1; FKH1; FKH1; FKHR; FKHR; Forkhead; Drosophila; homolog 1; rhabdomyosarcoma; Forkhead; Drosophila; homolog 1; rhabdomyosarcoma; Forkhead box O1; Forkhead box proteIn O1; Forkhead box proteIn O1A; Forkhead In rhabdomyosarcoma; Forkhead, Drosophila, homolog of, In rhabdomyosarcoma; FOXO1; FOXO1; FOXO1_HUMAN; FOXO1A; OTTHUMP00000018301.	WB	Human
	FOXO1(C-term) Antibody (YA5217) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FOXO1(C-term).

HY-P83052

	CEP55 Antibody (YA2797) CEP55; C10orf3; URCC6; Centrosomal proteIn of 55 kDa; Cep55; Up-regulated In colon cancer 6	WB, ICC/IF	Human, Rat
	CEP55 Antibody (YA2797) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CEP55.

HY-P80677

	FOXO3A Antibody (YA428) FOXO3; FKHRL1; FOXO3A; Forkhead box proteIn O3; AF6q21 proteIn; Forkhead In rhabdomyosarcoma-like 1	WB	Human
	FOXO3A Antibody (YA428) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXO3A.

HY-P83592

	DAZL Antibody (YA3337) DAZ homolog; DAZ like autosomal; DAZH; DAZL; DAZL1; DAZLA; Deleted In azoospermia like 1; GermlIne specific RNA bIndIng proteIn; SPGY like autosomal; SPGYLA; Tpx2	WB	Human
	DAZL Antibody (YA3337) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DAZL.

HY-P80817

	Phospho-FOXO3A (Ser253) Antibody (YA197) FOXO3; FKHRL1; FOXO3A; Forkhead box proteIn O3; AF6q21 proteIn; Forkhead In rhabdomyosarcoma-like 1	WB	Human, Mouse, Rat
	Phospho-FOXO3A (Ser253) Antibody (YA197) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-FOXO3A (Ser253).

HY-P86548

	Phospho-FOXO3A(Ser253) Antibody (YA6240) FOXO3; FKHRL1; FOXO3A; Forkhead box proteIn O3; AF6q21 proteIn; Forkhead In rhabdomyosarcoma-like 1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-FOXO3A(Ser253) Antibody (YA6240) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-FOXO3A(Ser253).

HY-P82235

	SERPING1 Antibody (YA1980) SERPInG1; C1In; C1NH; Plasma protease C1 Inhibitor; C1 Inh; C1Inh; C1 esterase Inhibitor; C1-InhibitIng factor; SerpIn G1	WB, IP	Human, Mouse, Rat
	SERPING1 Antibody (YA1980) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SERPING1.

HY-P85677

	NFkB p65 Antibody (YA5369) RELA; NFKB3; Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer In B-cells 3	WB, ICC/IF, ELISA	Human, Mouse,
	NFkB p65 Antibody (YA5369) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NFkB p65.

HY-P86492

	NF-κB p65 Antibody (YA6184) RELA; NFKB3; Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer In B-cells 3	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	NF-κB p65 Antibody (YA6184) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NF-κB p65.

HY-P80979

	HOPX Antibody (YA846) CAMEO antibody; heart odd homeobox 1 proteIn antibody; HOD antibody; HomeodomaIn-only proteIn antibody; HOP antibody; HOP homeobox antibody; HOP_HUMAN antibody; HOPX antibody; LAGY antibody; Lung cancer-associated Y proteIn antibody; NECC1 antibody; Not expressed In choriocarcInoma clone 1 antibody; Not expressed In choriocarcInoma proteIn 1 antibody; OB1 antibody; odd homeobox 1 proteIn antibody; Odd homeobox proteIn 1 antibody; OTTHUMP00000158970 antibody; SMAP31 antibody; TOTO antibody;	WB, IP	Human
	HOPX Antibody (YA846) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HOPX.

HY-P80764

	NF-KB p105/p50 Antibody (YA700) NFKB1; Nuclear factor NF-kappa-B p105 subunit; DNA-bIndIng factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer In B-cells 1	WB	Human, Mouse, Rat
	NF-KB p105/p50 Antibody (YA700) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NF-KB p105/p50.

HY-P83599

	MTA2 Antibody (YA3344) Mata1l1; Metastasis associated gene 1 like 1; Metastasis associated gene family member 2; Mmta2; MTA1L1; p53 target proteIn In deacetylase complex; PID	WB, IHC-P, ICC/IF, FC	Human
	MTA2 Antibody (YA3344) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MTA2.

HY-P86373

	NF-κB1 p105/p50 Antibody (YA6065) NFKB1; Nuclear factor NF-kappa-B p105 subunit; DNA-bIndIng factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer In B-cells 1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	NF-κB1 p105/p50 Antibody (YA6065) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NF-κB1 p105/p50.

HY-P83443

	SDF1 Antibody (YA3188) CXCL12; SDF1; SDF1A; SDF1B; Stromal cell-derived factor 1; SDF-1; hSDF-1; C-X-C motif chemokIne 12; IntercrIne reduced In hepatomas; IRH; hIRH; Pre-B cell growth-stimulatIng factor; PBSF	WB, ICC/IF	Human
	SDF1 Antibody (YA3188) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SDF1.

HY-P87345

	Themis Antibody (YA7028) C6orf190 antibody; C6orf207 antibody; MGC163388 antibody; ProteIn THEMIS antibody; SIGNALInG PHOSPHOPROTEIn SPECIFIC FOR T CELLS antibody; SPOT antibody; THEMIS antibody; THMS1_HUMAN antibody; Thymocyte expressed molecule Involved In selection antibody; Thymocyte selection associated antibody	WB, ICC/IF, IHC-P, FC	Human, Rat
	Themis Antibody (YA7028) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Themis.

HY-P85293

	NCoA-3 Antibody (YA4985) NCOA3; AIB1; BHLHE42; RAC3; TRAM1; Nuclear receptor coactivator 3; NCoA-3; ACTR; Amplified In breast cancer 1 proteIn; AIB-1; CBP-InteractIng proteIn; pCIP; Class E basic helix-loop-helix proteIn 42; bHLHe42; Receptor-associated coactivator	WB, ELISA	Human
	NCoA-3 Antibody (YA4985) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NCoA-3.

HY-P85369

	Smad4 Antibody (YA5061) SMAD4; DPC4; MADH4; Mothers agaInst decapentaplegic homolog 4; MAD homolog 4; Mothers agaInst DPP homolog 4; Deletion target In pancreatic carcInoma 4; SMAD family member 4; SMAD 4; Smad4; hSMAD4	WB, IHC-P, ICC/IF, FC, ELISA	Human
	Smad4 Antibody (YA5061) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Smad4.

HY-P86352

	Smad4 Antibody (YA6044) SMAD4; DPC4; MADH4; Mothers agaInst decapentaplegic homolog 4; MAD homolog 4; Mothers agaInst DPP homolog 4; Deletion target In pancreatic carcInoma 4; SMAD family member 4; SMAD 4; Smad4; hSMAD4	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Smad4 Antibody (YA6044) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Smad4.

HY-P81238

	Phospho-NF-κB p65 (Ser536) Antibody 1 Publications Verification Phospho-NF-KB p65 (Ser536) ; NF-kB p65 (phospho S536); p-NF-κB p65(Phospho-Ser536); RELA(phospho S536); NF kB P65; NF-kB p65; NFKBp65; NF-κBp65; p65 NF kappaB; p65 NFkB; NFKBp65; RELA; Transcription Factor p65; v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer In B cells 3 (p65)); V Rel Avian Reticuloendotheliosis Viral Oncogene Homolog A; v rel reticuloendotheliosis viral oncogene homolog A (avian); v-rel reticuloendotheliosis viral oncogene homolog A; p65NFKB; Avian reticuloendotheliosis viral (v rel) oncogene homolog A; MGC131774; NFKB 3; NFKB3; Nuclear Factor NF Kappa B p65 Subunit; Nuclear factor of kappa light polypeptide gene enhancer In B cells 3; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B Cells; TF65_HUMAN. NFκB-p65; NFκB p65; NF κB-p65; NFκBp65;	WB, IHC-P, FC	Human, Mouse, Rat
	Phospho-NF-κB p65 (Ser536) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-NF-κB p65 (Ser536).

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Cat. No.	Product Name		Classification

HY-148921

SDH-IN-2		Alkynes
SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 0.55 μg/mL. SDH-IN-2 is also an antifungal agent. SDH-IN-2 inhibits phytopathogenic fungia with average EC₅₀ values of 3.82-9.81 μg/mL for all the fungi . SDH-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-U00318

JAK-IN-11		Alkynes
JAK-IN-11 is a potent and selective JAK inhibitor extracted from patent WO2012122452A1, Compound II, has the potential for the skin disorders (such as cutaneous lupus) treatment . JAK-IN-11 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-153050

JAK-IN-24		Alkynes
JAK-IN-24 is a JAK inhibitor, with IC₅₀s of 0.534 and 24 nM at the presence of 4 μM or 1mM ATP, respectively. JAK-IN-24 also inhibits PBMC IL-15 induced STAT5 phosphorylation with an IC₅₀ of 86.171 nM . JAK-IN-24 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-149058

Neuraminidase-IN-13		Azide
Neuraminidase-IN-13 (Compound 10) is a neuraminidase inhibitor with antiviral activity and low cytotoxicity. Neuraminidase-IN-13 significantly inhibits NDV infection of Vero cells by preventing the release of viral particles from infected cells . Neuraminidase-IN-13 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-150781

EGFR-IN-71		Alkynes
EGFR-IN-71 is a potent narrow spectrum epidermal growth factor receptor (EGFR) inhibitor with IC₅₀ values of 3.7 μM. EGFR-IN-71 can be used for researching chordoma . EGFR-IN-71 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-149057

Neuraminidase-IN-12		Azide
NDV-IN-1 is an antiviral agent with high neuraminidase inhibitory activity. NDV-IN-1 exhibits in vitro inhibitory activity against Newcastle disease virus (NDV). NDV-IN-1 significantly inhibits NDV infection of Vero cells by preventing the release of virus particles from infected cells . Neuraminidase-IN-12 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-161407

AURKA-IN-1		Alkynes
AURKA-IN-1 (compound 9) is an cell-active covalent AURKA inhibitor. AURKA-IN-1 is a lysine-reactive activity probe .

HY-159119

hDHODH-IN-15		Alkynes
hDHODH-IN-15 (Compound H19) is an inhibitor for human dihydroguanylate dehydrogenase (hDHODH) with an IC₅₀ of 0.21 µM. hDHODH-IN-15 exhibits cytotoxicity in cancer cells NCI-H226, HCT-116, and MDA-MB-231, with IC₅₀ of 0.95-2.81 µM. hDHODH-IN-15 induces ferroptosis in HCT-116, and exhibits antitumor efficacy .

HY-159653

MASTL-IN-5		Azide
MASTL-IN-5 (compound 11) is a MASTL (microtubule-associated serine/threonine kinase-like) inhibitor, with a K_i of 0.018 nM .

HY-141859

PPO-IN-1		Alkynes
PPO-IN-1 is a potent protoporphyrinogen IX oxidase (PPO) inhibitor with a K_i value of 2.5 nM. PPO-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159128

hCAIX-IN-21		Azide
hCAIX-IN-21 (compound 16c) is a potent hCAIX inhibitor with K_I values of 5.2, 3.5, 12.6, 13600 nM for hCAIX, hCA II, hCA XII, hCA I, respectively. hCAIX-IN-21 inhibits cathepsin B enzyme activity .

HY-151872

HDAC-IN-48		Alkynes
HDAC-IN-48 is a potent HDAC inhibitor. HDAC-IN-48 is a hybrid molecule with great cytotoxic profile (GI₅₀~20 nM). HDAC-IN-48 consists of harmacophores of SAHA and CETZOLE molecules. HDAC-IN-48 induces ferroptosis and inhibits HDAC proteins . HDAC-IN-48 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159511

Hedgehog IN-7		Azide
Hedgehog IN-7 (Compound 8g), a purine derivative, acts as an inhibitor of Hedgehog, capable of reducing the expression of Hedgehog genes and inhibiting Hedgehog signaling. Hedgehog IN-7 has significant cytotoxicity and selectivity towards the Hedgehog pathway-dependent pancreatic cancer cell Mia-PaCa-2 cells and can be used in the research of pancreatic cancer .

HY-159589

BTK-IN-37		Azide
BTK-IN-37 (compound 8d) is a BTK inhibitor that can induce apoptosis in cancer cells. BTK-IN-37 targets BTK with K_i and IC₅₀ of 5.07 nM and 3.6 nM, respectively. BTK-IN-37 can also selectively induce enrichment of genes involved in necroptosis and pyroptosis .

HY-159129

hCAXII-IN-10		Azide
hCAXII-IN-10 (Compound 18b) is a dual inhibitor of human carbonic anhydrase isoform XII (hCAXII) and cathepsin B, with a K_i value of 2.2 nM. hCAXII-IN-10 can inhibit the role of hCAXII in providing tumors with a pH microenvironment conducive to tumor growth, and is expected to be used in the study of tumor diseases .

HY-159133

BuChE-IN-13		Azide
BuChE-IN-13 (compound 3) is a BuChE inhibitor and shows anti-Alzheimer activity. BuChE-IN-13 can be used for study of neurodegenerative disease .

HY-U00277

JAK-IN-10		Alkynes
JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders . JAK-IN-10 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159473

K-Ras-IN-3		Alkynes
K-Ras-IN-3 (compound 3) is a potent GDP-KRAS G12V inhibitor with an IC₅₀ value of 0.371 nM. K-Ras-IN-3 has the potential for the research of cancer .

HY-169157

HDAC6-IN-50		Alkynes
HDAC6-IN-50 (Compound 4) is a potent HDAC6 inhibitor with an IC₅₀ of 35 nM. HDAC6-IN-50 can be used for the study of Parkinson's disease (PD) and Alzheimer's disease (AD) research .

HY-163143

HDAC8-IN-6		Alkynes
HDAC8-IN-6 (compound 3) is a potent HDAC8 inhibitor with an IC₅₀ of 5.1 μM. HDAC8-IN-6 shows cytotoxicity .

HY-146314

MAO-B-IN-9		Alkynes
MAO-B-IN-9 (compound 16) is a potent, selective, BBB-penetrated, irreversible and time-dependent MAO-B (monoamine oxidase B) inhibitor, with an IC₅₀ of 0.18 μM. MAO-B-IN-9 prevents Aβ_1-42-induced neuronal cell death. MAO-B-IN-9 shows neuroprotective effects, which may be the result of its Aβ_1-42 anti-aggregation effects . MAO-B-IN-9 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-162446

pan-KRAS-IN-13		Alkynes
pan-KRAS-IN-13 (compound 2) is a potent inhibitor of KRAS, with IC₅₀s of 2.75 nM and 2.89 nM for G12D and G12V, respectively

HY-152074

CD73-IN-14		Alkynes
D73-IN-14 is a potent, selective and orally active CD73 inhibitor with an IC₅₀ value of 0.17 nM. CD73-IN-14 increases the number of tumor-infiltrating CD8 ⁺ cells and shows anti-tumor activity . CD73-IN-14 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-146691

hMAO-B-IN-2		Alkynes
hMAO-B-IN-2 (compound 6j) is an orally active, potent, selective and BBB penetrated and competitive reversible hMAO-B inhibitor, with an IC₅₀ of 4 nM. hMAO-B-IN-2 shows low toxicity and good neuroprotective effects in SH-SY5Y cell. hMAO-B-IN-2 can be used for alzheimer’s disease research . hMAO-B-IN-2 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159562

COX-2-IN-46		Azide
COX-2-IN-46 (compound 5m) is an anti-inflammatory agent with potent analgesic activity. COX-2-IN-46 exhibits a significant inhibitory effect on COX-2 (IC₅₀=87.74 nM) .

HY-156555

pan-KRAS-IN-3		Alkynes
pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor. pan-KRAS-IN-3 can be used for research of cancers . pan-KRAS-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-153831

c-Met-IN-17		Alkynes
c-Met-IN-17 is a potent c-Met kinase inhibitor with an IC₅₀ of 0.031 μM. c-Met-IN-17 can be used in anticancer research. . c-Met-IN-17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-148908

TNF-α-IN-8		Azide
TNF-α-IN-8 (compound I-42) is a TNF-α inhibitor. TNF-α-IN-8 is an isoindole-imide compound. TNF-α-IN-8 can be used for the research of cancer, heart disease, osteoporosis, inflammatory, allergic and autoimmune diseases . TNF-α-IN-8 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-145259

HDAC6-IN-3		Alkynes
HDAC6-IN-3 (Compound 14), an antiprostate cancer agent, is a potent, orally active HDAC6 inhibitor with IC₅₀s ranging from 0.02-1.54 μM for HDAC1/2/3/6/8/10. HDAC6-IN-3 is also an effective MAO-A (IC₅₀=0.79 μM) and LSD1 inhibitor . HDAC6-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159561

COX-1-IN-2		Azide
COX-1-IN-2 (compound 5h) is an anti-inflammatory agent with potent analgesic activity. COX-1-IN-2 exhibits a significant inhibitory effect on COX-1 (IC₅₀=38.76 nM) .

HY-159132

CAIX/CAXII-IN-2		Azide
CAIX/CAXII-IN-2 (compound 23) is a CAIX/CAXII inhibitor, with K_i values of 8.9 nM and 5.3 nM for CAIX/CAXII, respectively. CAIX/CAXII-IN-2 can be used in cancer research .

HY-144313

Galectin-3-IN-2		Alkynes
Galectin-3-IN-2 (Compound 9) is a potent multivalent inhibitor of galectin-3 (Gal-3; IC₅₀=8.3 μM). Galectin-3 participates in many cancer-related metabolic processes .

HY-149880

c-Met-IN-18		Alkynes
c-Met-IN-18 is ATP competitive type-III c-MET inhibitor of WT and D1228V mutant c-MET. c-Met-IN-18 has inhibitory for WT/D1228V with an IC₅₀ value of 0.013/0.20 ^e.c-Met-IN-18 can be used for the research of c-MET driven cancers . c-Met-IN-18 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-131036

MAO-IN-M30 dihydrochloride		Alkynes
MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC₅₀=37 nM) and MAO-B (IC₅₀=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease . MAO-IN-M30 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159615

Cbl-b-IN-21		Azide
Cbl-b-IN-21 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Cbl-b-IN-21 can be used for synthesis PROTAC Cbl-b-IN-1 (HY-159608) .

HY-120330

Nek2-IN-5		Alkynes
Nek2-IN-5 (compound 6) is a potent and irreversible Nek2 ((Never in mitosis gene a)-related kinase 2) inhibitior . Nek2-IN-5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159151

AChE/Aβ-IN-6		Azide
BACE1-IN-15 (compound 4j) is a potent inhibitor of BACE1 (β-secretase) that can inhibited the copper ion induced Aβ toxicity, with the EC₅₀ of 0.68 μM .

HY-173115

15-LOX-IN-2		Alkynes
15-LOX-IN-2 (Compound 2a) is an orally active COX-2/15-LOX inhibitor and a partial agonist of PPARγ. 15-LOX-IN-2 has anti-inflammatory activity and inhibits the levels of 20-HETE, IL-1β and TNF-α in RAW 264.7 cells treated with LPS (HY-D1056). In addition, 15-LOX-IN-2 has significant glucose uptake capacity in the absence of insulin. 15-LOX-IN-2 can be used for the research of metabolic diseases .

HY-175484

PDIA1-IN-1		Alkynes
PDIA1-IN-1 is a protein disulfide isomerase 1 (PDIA1) inhibitor. PDIA1-IN-1 can inhibit NLRP3 inflammasome assembly and activity, with an IC₅₀ value of 1 μM. PDIA1-IN-1 can reduce IL-1β secretion. PDIA1-IN-1 can be used for the researches of inflammation and neurological disease .

HY-15843

MIR96-IN-1		Azide
MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with K_ds of 1.3, 9.4, 3.4, 1.3 and 7.4 μM for RNA1, RNA2, RNA3, RNA4 and RNA5, respectively . MIR96-IN-1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-168879

GPX4-IN-16		Azide
GPX4-IN-16 ((R)-9i) is a potent GPX4 inhibitor with an K_d value of 20.4 nM. GPX4-IN-16 shows cytotoxicity. GPX4-IN-16 shows anticancer activity .

HY-152233

Reverse transcriptase-IN-4		Azide
Reverse transcriptase-IN-4 (compound F10) is a potent and selective non-nucleoside reverse transcriptase (NNRT) inhibitor with an EC₅₀ value of 0.053 μM for wild-type HIV-1 and an EC₅₀ value of 0.26 μM for HIV-1 mutant E138K . Reverse transcriptase-IN-4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-126271

PYCR1-IN-1		Alkynes
PYCR1-IN-1 (compound 4) is a pyrroline-5-carboxylate reductase 1 (PYCR1) inhibitor with an IC₅₀ of 8.8 µM. PYCR1-IN-1 has anticancer effects .

HY-159921

Tubulin Polymerization-IN-1 prodrug		Alkynes
Tubulin Polymerization-IN-1 prodrug (Compound 2b) is a palladium (Pd)-mediated tubulin polymerization inhibitor prodrug. Developed based on colchicine binding site inhibitors (CBSIs), it reduces toxicity and enhances targeted release properties. Compared to the parent compound, Tubulin Polymerization-IN-1 prodrug exhibited 68.3-fold lower cytotoxicity, which can be restored in situ in the presence of Pd resin. Mechanistic studies showed that its anticancer activity is consistent with CBSIs. In vivo, Tubulin Polymerization-IN-1 prodrug significantly inhibited tumor growth (63.2%) when activated by Pd resin. It holds promise for research in the field of anticancer therapy .

HY-157029S

KRASG12D-IN-1		Alkynes
KRASG12D-IN-1 (compound 22) is a KRAS ^G12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition .

HY-175524

BChE/MAO-B-IN-2		Alkynes
BChE/MAO-B-IN-2 is a dual inhibitor of BChE (IC₅₀ = 0.05 μM, K_i = 0.01 μM) and MAO-B (IC₅₀ = 0.45 μM, K_i = 0.08 μM) with good blood-brain barrier permeability. BChE/MAO-B-IN-2 exhibits antioxidant activity, including DPPH radical scavenging, CUPRAC copper ion reduction, and superoxide anion scavenging. BChE/MAO-B-IN-2 can be used for the study of Alzheimer's disease (AD) .

HY-142706

MAO A/HDAC-IN-1		Alkynes
MAO A/HDAC-IN-1 is a dual?inhibitor?of monoamine oxidase A (MAO A) and HDAC. MAO A/HDAC-IN-1 can be used for glioma research . MAO A/HDAC-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159564

iNOS/COX-2-IN-3		Azide
iNOS/COX-2-IN-3 (compound 7d) is a dual inhibitor of iNOS and COX-2, with potential anti-inflammatory activity against LPS (HY-D1056)-induced RAW 264.7 cells (IC₅₀=3.48 μM). iNOS/COX-2-IN-3 has good plasma stability, oral activity and gastric safety, and its inhibitory activity on iNOS and COX-2 expression is 5.43-fold and 2.37-fold that of Indomethacin (HY-14397), respectively .

HY-162994

KAT6A-IN-1		Alkynes
KAT6A-IN-1 (compund 5) is a KAT6A inhibitor .

HY-136211

Cystathionine-γ-lyase-IN-1		Alkynes
Cystathionine-γ-lyase-IN-1 is a selective cystathionine γ-lyase (CSE) enzyme inhibitor with an IC₅₀ of 6.3 μM . Cystathionine-γ-lyase-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-167012

306Oi9-cis2		Cationic Lipids
306Oi9-cis2 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. 306Oi9-cis2 can be used in the preparation of liposomes .

HY-167011

Al-28		Cationic Lipids
Al-28 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. Al-28 can be used in the preparation of liposomes .

HY-167015

1O14		Cationic Lipids
1O14 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. 1O14 can be used in the preparation of liposomes .

HY-Y0966

Glycine 10+ Cited Publications		Fillers
Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis .

HY-153734

Inactive ASO (in vivo) sodium		Antisense Oligonucleotides
Inactive ASO (in vivo) sodium is an inactive Antisense Oligonucleotide. ASO is a class of oligonucleotide molecules, usually composed of 20-30 bases, used to interfere with or regulate gene expression. Inactive ASO (in vivo) sodium is not targeted in the rodent genome and can be used as a negative control for Tofersen. Inactive ASO (in vivo) sodium contains thiophosphate skeleton modification and MOE modification. Cytosine in Inactive ASO (in vivo) is 5' methylcytosine. See References for the location of chemical modifications

HY-W392209A

Copovidone (50% in ethanol)		Binders
Copovidone can be used as an excipient, such as Film formers, adhesives, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .

HY-B2232

Benzalkonium (chloride) (51% in water) 2 Publications Verification Alkyldimethylbenzylammonium chloride		Solubilizing Agents
Benzalkonium (Alkyldimethylbenzylammonium) chloride (51% in water) is a potent anti-microbial agent, used as a preservative in eye drops.

HY-R04609B

In Vivo Rgma Rat Pre-designed siRNA Set A-2‍		siRNAs Rat Pre-designed siRNA Sets
In Vivo Rgma Rat Pre-designed siRNA Set A-2‍ is a siRNA product designed for the Rgma (Rat) gene and can be used for in vivo experiments in rats.

HY-167002

RM 137-15		Cationic Lipids
RM 137-15 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. RM 137-15 can be used in the preparation of liposomes .

HY-160276

DOPE-PEG-Fluor 555,MW 5000		Pegylated Lipids Fluorescent Lipids
DOPE-PEG-Fluor 555, MW 5,000 is consist of a DOPE phospholipid which is an unsaturated phospholipid and a Fluor 555 dye which is a bright orange cyanine dye that can be used in fluorescence microscopy, FRET and other in vivo imaging techniques.

HY-R04609C

In Vivo Rgma Rat Pre-designed siRNA Set A-3		siRNAs Rat Pre-designed siRNA Sets
In Vivo Rgma Rat Pre-designed siRNA Set A-3 is a siRNA product designed for the Rgma (Rat) gene and can be used for in vivo experiments in rats.

HY-R04609A

In Vivo Rgma Rat Pre-designed siRNA Set A-1		siRNAs Rat Pre-designed siRNA Sets
In Vivo Rgma Rat Pre-designed siRNA Set A-1 is a siRNA product designed for the Rgma (Rat) gene and can be used for in vivo experiments in rats.

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In (Lu)-related protein p80

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