2. Immunology/Inflammation Apoptosis
  3. CD28 IFNAR TNF Receptor Interleukin Related
  4. CD28-IN-1

CD28-IN-1 (Compound 19MS-5) is a CD28 inhibitor with a KD of 12.48  μM. CD28-IN-1 has a superior binding capacity to CD28 and potently inhibits CD28-B7 interactions. CD28-IN-1 inhibits CD28-driven immune activation and suppresses cytokine (IFN-γ, IL-2 and TNF-α) production in primary human T cells co-cultured with tumor spheroids and human epithelial tissues. CD28-IN-1 can be used for tumor immunity research.

For research use only. We do not sell to patients.

CD28-IN-1

CD28-IN-1 Chemical Structure

CAS No. : 1465291-19-3

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CD28-IN-1 Related Antibodies

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Description

CD28-IN-1 (Compound 19MS-5) is a CD28 inhibitor with a KD of 12.48  μM. CD28-IN-1 has a superior binding capacity to CD28 and potently inhibits CD28-B7 interactions. CD28-IN-1 inhibits CD28-driven immune activation and suppresses cytokine (IFN-γ, IL-2 and TNF-α) production in primary human T cells co-cultured with tumor spheroids and human epithelial tissues. CD28-IN-1 can be used for tumor immunity research[1].

IC50 & Target[1]

IL-2

 

Molecular Weight

315.32

Formula

C16H17N3O4
CAS No.
SMILES

O=C1N(C)C2=CC=CC(C(OCCC3=C(C)NN=C3C)=O)=C2O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CD28-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CD28-IN-11465291-19-3CD28IFNARTNF ReceptorInterleukin RelatedInterferon-α/β receptorInterferon-alpha/beta receptor Tumor Necrosis Factor ReceptorTNFRILCD28-B7Immune activationT cellsTumor immunityInhibitorinhibitorinhibit

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