2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. FGFR-IN-18

FGFR-IN-18 (Compound KF7) is a lysine-targeting FGFR covalent inhibitor, with IC50s of: 1.1 nM for FGFR2, 1.3 nM for FGFR1, 31.5 nM for FGFR4. FGFR-IN-18 also has affinity for FGFR3 (inhibition rate of 52% at 10 nM). FGFR-IN-18 covalently modifies Lys485 (an reactive site of FGFRs).

For research use only. We do not sell to patients.

FGFR-IN-18 Chemical Structure

FGFR-IN-18 Chemical Structure

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FGFR-IN-18 Related Antibodies

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Description

FGFR-IN-18 (Compound KF7) is a lysine-targeting FGFR covalent inhibitor, with IC50s of: 1.1 nM for FGFR2, 1.3 nM for FGFR1, 31.5 nM for FGFR4. FGFR-IN-18 also has affinity for FGFR3 (inhibition rate of 52% at 10 nM). FGFR-IN-18 covalently modifies Lys485 (an reactive site of FGFRs)[1].

IC50 & Target[1]

FGFR2

1.1 nM (IC50)

FGFR1

1.3 nM (IC50)

FGFR4

31.5 nM (IC50)

FGFR3

 

Molecular Weight

643.69

Formula

C32H37N9O6
SMILES

COC1=CC(CCC2=CC(NC3=NC(NCC4=CC=CC(CNC5=C(C(C5=O)=O)OC)=C4)=NC(NCCOC)=N3)=NN2)=CC(OC)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FGFR-IN-18 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGFR-IN-18FGFRFibroblast growth factor receptorLys485FGFR1FGFR2FGFR3FGFR4Inhibitorinhibitorinhibit

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