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  4. Multi-target kinase-IN-6

Multi-target kinase-IN-6 is a Multiple target kinase inhibitor. Multi-target kinase-IN-6 can inhibit cardiac RyR2- and NaV1.5-channels but stimulate SERCA2a pump activity. Multi-target kinase-IN-6 can be used for the research of cardiovascular disease, such as heart failure.

For research use only. We do not sell to patients.

Multi-target kinase-IN-6

Multi-target kinase-IN-6 Chemical Structure

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Multi-target kinase-IN-6 Related Antibodies

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Description

Multi-target kinase-IN-6 is a Multiple target kinase inhibitor. Multi-target kinase-IN-6 can inhibit cardiac RyR2- and NaV1.5-channels but stimulate SERCA2a pump activity. Multi-target kinase-IN-6 can be used for the research of cardiovascular disease, such as heart failure[1].

In Vitro

Multi-target kinase-IN-6 (Compound 12) (25 μM, 24 h) inhibits RyR2-mediated Ca2+ leakage in HEK-293 RyR2 R-CEPIA1er cells[1].
Multi-target kinase-IN-6 (1.1 μM, 2 h) activates sarcoplasmic reticulum Ca2+-ATPase 2a (SERCA2a) in HL-1 cardiomyocytes[1].
Multi-target kinase-IN-6 (2.3 nM, 10 mins) significantly enhances the ATPase activity of SERCA2a in sarcoplasmic reticulum microsomal vesicles isolated from adult mouse ventricles[1].
Multi-target kinase-IN-6 (10 μM, 30 mins) inhibits NaV1.5-mediated Na+ influx in CHO NaV1.5 Duo cells[1].
Multi-target kinase-IN-6 (10 μM, 24 h) causes no significant cell death in HL-1 cardiomyocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Multi-target kinase-IN-6 Related Antibodies
Molecular Weight

481.46

Formula

C26H36BN3O3S
SMILES

OC(C=C1/C=C/C[NH+](CCCCCCN2CCSC3=CC=C(C=C3C2)OC)[BH2-]C#N)=C(C=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Multi-target kinase-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-target kinase-IN-6OthersRyR2NaV1.5SERCA2aheart failureHL-1Inhibitorinhibitorinhibit

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