2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC6-IN-21

HDAC6-IN-21 (compound 13) is airreversibleinhibitor of histonedeacetylase 6 (HDAC6).

For research use only. We do not sell to patients.

HDAC6-IN-21 Chemical Structure

HDAC6-IN-21 Chemical Structure

CAS No. : 2920929-76-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Solution
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HDAC6-IN-21 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC6-IN-21 (compound 13) is airreversibleinhibitor of histonedeacetylase 6 (HDAC6)[1].

Molecular Weight

321.28

Formula

C14H13F2N5O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN=C(NCC2=CC=CC=C2)N=C1)NNC(C(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (389.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1125 mL 15.5627 mL 31.1255 mL
5 mM 0.6225 mL 3.1125 mL 6.2251 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1125 mL 15.5627 mL 31.1255 mL 77.8137 mL
5 mM 0.6225 mL 3.1125 mL 6.2251 mL 15.5627 mL
10 mM 0.3113 mL 1.5563 mL 3.1125 mL 7.7814 mL
15 mM 0.2075 mL 1.0375 mL 2.0750 mL 5.1876 mL
20 mM 0.1556 mL 0.7781 mL 1.5563 mL 3.8907 mL
25 mM 0.1245 mL 0.6225 mL 1.2450 mL 3.1125 mL
30 mM 0.1038 mL 0.5188 mL 1.0375 mL 2.5938 mL
40 mM 0.0778 mL 0.3891 mL 0.7781 mL 1.9453 mL
50 mM 0.0623 mL 0.3113 mL 0.6225 mL 1.5563 mL
60 mM 0.0519 mL 0.2594 mL 0.5188 mL 1.2969 mL
80 mM 0.0389 mL 0.1945 mL 0.3891 mL 0.9727 mL
100 mM 0.0311 mL 0.1556 mL 0.3113 mL 0.7781 mL
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HDAC6-IN-21 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-212920929-76-4HDACHistone deacetylasesInhibitorinhibitorinhibit

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