2. Neuronal Signaling Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Ferroptosis Monoamine Oxidase Glutathione Peroxidase Reactive Oxygen Species (ROS) Tau Protein Amyloid-β
  4. MAO-B-IN-45

MAO-B-IN-45 is a dual inhibitors of ferroptosis and MAO-B. MAO-B-IN-45 shows selectivity towards MAO-B with an IC50 of 87.47 nM and selectivity exceeding 229-fold for MAO-B over MAO-A. MAO-B-IN-45 has excellent antiferroptosis activity through modulation of the iron metabolic pathway and GSH-GPX4 axis in vitro. MAO-B-IN-45 improves cognitive and behavioral impairments in 3×Tg (APP/Tau/Ps1) AD mouse and significantly reduced the levels of ferritin heavy chain 1 (FTH1), APP, and Tau phosphorylation (p-Tau) proteins in the brain[1].

For research use only. We do not sell to patients.

MAO-B-IN-45 Chemical Structure

MAO-B-IN-45 Chemical Structure

CAS No. : 3069915-36-9

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MAO-B-IN-45 Related Antibodies

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Description

MAO-B-IN-45 is a dual inhibitors of ferroptosis and MAO-B. MAO-B-IN-45 shows selectivity towards MAO-B with an IC50 of 87.47 nM and selectivity exceeding 229-fold for MAO-B over MAO-A. MAO-B-IN-45 has excellent antiferroptosis activity through modulation of the iron metabolic pathway and GSH-GPX4 axis in vitro. MAO-B-IN-45 improves cognitive and behavioral impairments in 3×Tg (APP/Tau/Ps1) AD mouse and significantly reduced the levels of ferritin heavy chain 1 (FTH1), APP, and Tau phosphorylation (p-Tau) proteins in the brain[1].

In Vitro

MAO-B-IN-45 (compound 21d) is a reversible hMAO-B inhibitor with inhibition constant a Ki value of 100.6 nM , which displays high hMAO-B inhibitory activity, and the inhibition rate are 94.81% (10 μM) and 76.31% (1 μM)[1].

MAO-B-IN-45 (0.1-75 μM, 24 h) shows favorable safety in PC12 cells and HT22 cells[1].

MAO-B-IN-45 (1-50 μM, 24 h) effectively mitigates ferroptosis induced by RSL3 (HY-100218A) or Erastin (HY-15763) in a dose-dependent manner in HT22 cells[1].

MAO-B-IN-45 (10-50 μM, 24 h) reduces intracellular ROS production in HT22 cells[1].

MAO-B-IN-45 (15-100 μM, 24 h) effectively suppresses ferroptosis by both reducing intracellular iron accumulation and enhancing the GSH dependent pathway in HT22 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-45 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HT22 cells, PC12 cells
Concentration: 25, 50, and 75 μM (HT22 cells), 0.1, 1, 10, 20, 30, 40, 50, 75 μM (PC12 cells)
Incubation Time: 24 h
Result: Showed favorable safety, maintaining a cell viability of 83.56% on PC12 cells and 86.47% on HT22 cells at the highest test concentration (75 μM), warranting further investigation.

Cell Cytotoxicity Assay[1]

Cell Line: RSL3/Erastin-induced HT22 cells
Concentration: 1, 5, 10, 25, 50 μM
Incubation Time: 24 h
Result: Reduced ferroptosis induced by RSL3 and Erastin at a concentration of 10 μM and completely restored cell viability to normal levels at 50 μM.
In Vivo

MAO-B-IN-45 (Compound 21d) (10 mg/kg, i.p., daily for 35 days) alleviates memory and cognitive dysfunction in the 3×Tg (APP/Tau/Ps1) mouse model of AD, demonstrating good safety in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Triple-transgenic (APP/Tau/Ps1) mice (30-35 g, 7 months)[1].
Dosage: 10 mg/kg
Administration: Intraperitoneal injection daily for 35 days
Result: Increased the number of entries, and reduced the latency and distance to the platform, showing effects comparable to those observed in the safinamide and donepezil groups.
Not markedly different from wild-type mice in cognitive function.
No abnormalities in the tissues (heart, liver, spleen, lung, kidney) compared to those of wild type mice (H&E staining).
Normalized FTH1 levels in 3×Tg mice, and significantly increased the expression level of GPX4.
Reduced the protein level of APP, and decreased the site-specificity in p-Tau at Ser202/Thr205.
Molecular Weight

315.75

Formula

C17H14ClNO3
CAS No.
SMILES

CN1C(C(O)=CC2=CC=C(C=C21)OCC3=CC=C(C=C3)Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MAO-B-IN-45 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-453069915-36-9FerroptosisMonoamine OxidaseGlutathione PeroxidaseReactive Oxygen Species (ROS)Tau ProteinAmyloid-βMAOβ-amyloid peptideAβAbetaAlzheimer’s disease (AD)Monoamine oxidase B (MAO-B)GSH-GPX4ROSInhibitorinhibitorinhibit

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