2. Apoptosis
  3. Bcl-2 Family Apoptosis
  4. Mcl-1-IN-17

Mcl-1-IN-17 (Compound 25) is an orally active Myeloid Cell Leukemia 1 (Mcl-1) inhibitor with a Ki < 0.08  nM. Mcl-1-IN-17 has a significant antiproliferative activity (GI50s of 39 and 105  nM for H929 and A427 cells, respectively) and inhibits cell apoptosis. Mcl-1-IN-17 can be used for hematological and solid cancers research.

For research use only. We do not sell to patients.

Mcl-1-IN-17

Mcl-1-IN-17 Chemical Structure

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Mcl-1-IN-17 Related Antibodies

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Description

Mcl-1-IN-17 (Compound 25) is an orally active Myeloid Cell Leukemia 1 (Mcl-1) inhibitor with a Ki < 0.08  nM. Mcl-1-IN-17 has a significant antiproliferative activity (GI50s of 39 and 105  nM for H929 and A427 cells, respectively) and inhibits cell apoptosis. Mcl-1-IN-17 can be used for hematological and solid cancers research[1].

IC50 & Target[1]

Mcl-1

<0.08 nM (Ki)

Molecular Weight

827.79

Formula

C44H48Cl2N6O6
SMILES

CC1=C(Cl)C(C)=CC(OCCCC2=C(C(N(C3=CC(OC)=C(OC)C4=C3N(CCCOC5)C(C(N(C)C)=O)=C4)C[C@H]6C)=O)N6C7=C2C=CC(Cl)=C7C(C5=N8)=CN8C)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Mcl-1-IN-17 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mcl-1-IN-17Bcl-2 FamilyApoptosisMyeloid Cell Leukemia 1Mcl-1AntiproliferativeHematologicalSolid cancersInhibitorinhibitorinhibit

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