2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. P-gp-IN-32

P-gp-IN-32 is a P-glycoprotein (P-gp) inhibitor. P-gp-IN-32 exhibits low cytotoxicity and potent multidrug resistance (MDR) reversal activity against Doxorubicin (HY-15142A) in MCF7/ADR cells (IC50 = 0.11 μM, reversal fold (RF) = 215.9). P-gp-IN-32 can bind to P-gp directly, induce a conformation change of P-gp and inhibit the efflux function. P-gp-IN-32 can be used for the research of cancer, such as breast cancer.

For research use only. We do not sell to patients.

P-gp-IN-32

P-gp-IN-32 Chemical Structure

CAS No. : 2918249-59-7

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P-gp-IN-32 Related Antibodies

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Description

P-gp-IN-32 is a P-glycoprotein (P-gp) inhibitor. P-gp-IN-32 exhibits low cytotoxicity and potent multidrug resistance (MDR) reversal activity against Doxorubicin (HY-15142A) in MCF7/ADR cells (IC50 = 0.11 μM, reversal fold (RF) = 215.9). P-gp-IN-32 can bind to P-gp directly, induce a conformation change of P-gp and inhibit the efflux function. P-gp-IN-32 can be used for the research of cancer, such as breast cancer[1].

In Vitro

P-gp-IN-32 (Compound BP3p) (5 μM) shows growth inhibition rates below 25% in both MCF-7 and MCF-7/ADR cells[1].
P-gp-IN-32 has a RF of 215.9 combined with Doxorubicin (HY-15142A) (IC50 of 0.11 μM) in MCF-7/ADR cells[1].
P-gp-IN-32 (2.5-5 μM, 4 h) increases Rhodamine 123 accumulation in MCF-7/ADR cells in a dose-dependent manner[1].
P-gp-IN-32 (0.5-5 μM, 48 h) has no significant effect on P-gp expression in MCF-7/ADR cells[1].
P-gp-IN-32 (50 μM) enhances UIC-2 antibody (HY-P990196) binding to P-gp in MCF-7/ADR cells[1].
P-gp-IN-32 (5 μM, 5 days) reduces the volume of MCF-7/ADR 3D tumor spheroids combined with Doxorubicin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

P-gp-IN-32 Related Antibodies

Western Blot Analysis[1]

Cell Line: MCF-7/ADR cells
Concentration: 0.5, 2.5 and 5 μM
Incubation Time: 48 h
Result: Did not reduce P-gp expression.
Molecular Weight

562.65

Formula

C35H34N2O5
CAS No.
SMILES

COC1=CC(C2=CC3=C(N(C(C(N4CCC5=C(C4)C=C(C(OC)=C5)OC)=O)=C3)CC6=CC=C(C=C6)OC)C=C2)=CC=C1
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Purity & Documentation
References
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P-gp-IN-32 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P-gp-IN-322918249-59-7P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243MDRMCF7/ADRBreast cancerInhibitorinhibitorinhibit

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