2. Membrane Transporter/Ion Channel
  3. Proton Pump
  4. V-ATPase-IN-1

V-ATPase-IN-1 (Compound 3b-03) is a Vacuolar-type H+-ATPases (V-ATPase) inhibitor (IC50 = 194.80 μM) that can effectively target the V-ATPase subunit A (Kd = 0.803 μM). V-ATPase-IN-1 exhibits insecticidal activity against M. separata (LC50 = 2.64 mM) and contributes to research in the development of chemical insecticides.

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V-ATPase-IN-1 Chemical Structure

V-ATPase-IN-1 Chemical Structure

CAS No. : 1243603-61-3

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V-ATPase-IN-1 Related Antibodies

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Description

V-ATPase-IN-1 (Compound 3b-03) is a Vacuolar-type H+-ATPases (V-ATPase) inhibitor (IC50 = 194.80 μM) that can effectively target the V-ATPase subunit A (Kd = 0.803 μM). V-ATPase-IN-1 exhibits insecticidal activity against M. separata (LC50 = 2.64 mM) and contributes to research in the development of chemical insecticides[1].

IC50 & Target

IC50: 194.8 μM (V-ATPase)[1].
Molecular Weight

353.84

Formula

C21H20ClNO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC(CNC2=CC=CC=C2)=CC(OC)=C1OCC3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (353.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8261 mL 14.1307 mL 28.2614 mL
5 mM 0.5652 mL 2.8261 mL 5.6523 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8261 mL 14.1307 mL 28.2614 mL 70.6534 mL
5 mM 0.5652 mL 2.8261 mL 5.6523 mL 14.1307 mL
10 mM 0.2826 mL 1.4131 mL 2.8261 mL 7.0653 mL
15 mM 0.1884 mL 0.9420 mL 1.8841 mL 4.7102 mL
20 mM 0.1413 mL 0.7065 mL 1.4131 mL 3.5327 mL
25 mM 0.1130 mL 0.5652 mL 1.1305 mL 2.8261 mL
30 mM 0.0942 mL 0.4710 mL 0.9420 mL 2.3551 mL
40 mM 0.0707 mL 0.3533 mL 0.7065 mL 1.7663 mL
50 mM 0.0565 mL 0.2826 mL 0.5652 mL 1.4131 mL
60 mM 0.0471 mL 0.2355 mL 0.4710 mL 1.1776 mL
80 mM 0.0353 mL 0.1766 mL 0.3533 mL 0.8832 mL
100 mM 0.0283 mL 0.1413 mL 0.2826 mL 0.7065 mL
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V-ATPase-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

V-ATPase-IN-11243603-61-3Proton PumpM. separatainsecticidesInhibitorinhibitorinhibit

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