2. Others Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. Isotope-Labeled Compounds JAK
  4. JAK2-IN-11

JAK2-IN-11 (Example 6) is a JAK2 kinase inhibitor with IC50 ≤10 nM against JH2 BIND WT/V617F. JAK2-IN-11 has antitumor activity.

For research use only. We do not sell to patients.

JAK2-IN-11

JAK2-IN-11 Chemical Structure

CAS No. : 3057053-17-2

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Based on 1 publication(s) in Google Scholar

JAK2-IN-11 Related Antibodies

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Description

JAK2-IN-11 (Example 6) is a JAK2 kinase inhibitor with IC50 ≤10 nM against JH2 BIND WT/V617F. JAK2-IN-11 has antitumor activity[1].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

IC50 & Target

JAK2-WT

≤10 nM (IC50)

JAK2-V617F

≤10 nM (IC50)

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JAK2-IN-11 Related Antibodies
Molecular Weight

639.64

Formula

C31H28D3F3N8O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N([C@H]2C[C@@H](CC2)NC(OC)=O)C3=CC(NC4=NC5=C(C=CC=C5C(F)(F)F)C(C(N6CCC(CC6)C#N)=O)=C4)=NC=C3N1C([2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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JAK2-IN-11 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK2-IN-113057053-17-2Isotope-Labeled CompoundsJAKJanus kinaseJAK2 InhibitorantitumorInhibitorinhibitorinhibit

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HY-169326S
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