2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. 6PGD-IN-2

6PGD-IN-2 is an uncompetitive 6-phosphogluconate dehydrogenase (6PGD) inhibitor with an IC50 of 5.1 μM. 6PGD-IN-2 disrupts 6PGD oligomerization in a substrate-dependent manner. 6PGD-IN-2 results in a decrease of NADPH and Ru-5-P production as well as DNA synthesis in A549 cells. 6PGD-IN-2 can used for the studies of non-small cell carcinoma and liver cancer.

For research use only. We do not sell to patients.

6PGD-IN-2

6PGD-IN-2 Chemical Structure

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6PGD-IN-2 Related Antibodies

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Description

6PGD-IN-2 is an uncompetitive 6-phosphogluconate dehydrogenase (6PGD) inhibitor with an IC50 of 5.1 μM. 6PGD-IN-2 disrupts 6PGD oligomerization in a substrate-dependent manner. 6PGD-IN-2 results in a decrease of NADPH and Ru-5-P production as well as DNA synthesis in A549 cells. 6PGD-IN-2 can used for the studies of non-small cell carcinoma and liver cancer[1].

In Vitro

Enpp-1-IN-27 (Compound 19n) (0-300 μM) exhibits non-competitive inhibition characteristics against both 6PG and NADP+, with inhibition constants (Ki) of 64 μM (6PG) and 9.5 μM (NADP+), respectively[1].
Enpp-1-IN-27 (0-10 μM, 72 h-14 d) inhibits A549 cells (antiviability potency with an EC50 of 9.0 μM) and Huh7 cells proliferation and colony formation[1].
6PGD-IN-2 (0-40 μM) reduces the NADPH/NADP+ ratio, Ru-5-P levels, and DNA synthesis in A549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6PGD-IN-2 Related Antibodies
Molecular Weight

461.14

Formula

C16H9BrCl2FN3OS
SMILES

O=C(NC1=NN=C(C2=CC=C(Br)C=C2F)S1)CC3=CC=C(Cl)C(Cl)=C3
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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6PGD-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6PGD-IN-2DNA/RNA SynthesisA549 cellsHuh7 cellsPentose phosphate pathway (PPP)Metabolic reprogrammingInhibitorinhibitorinhibit

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