ALK Antibody (YA6061)

ALK Antibody (YA6061) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ALK. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human.

ALK is a neuronal receptor tyrosine kinase transiently expressed in specific nervous system regions, playing crucial roles in neurogenesis and differentiation. It also regulates energy homeostasis by controlling white adipose tissue lipolysis and sympathetic tone (By similarity). Activated by ALKAL2 (but not ALKAL1), it initiates intracellular signaling through MAPK pathway activation, phosphorylating targets like CBL, FRS2, IRS1, and SHC1. ALK may also be modulated by pleiotrophin (PTN) and midkine (MDK), which promote anti-apoptotic signaling and cell proliferation via MAPK/PI3K pathways. Additionally, ALK drives NF-κB activation through IRS1-AKT, essential for MDK-mediated autocrine growth and survival.

Q9UM73

Predicted band size: 177 kDa; Observed band size: 220 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human

IHC: 1:200-1:1000; WB: 1:2000-1:10000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200;

WB, IHC-P, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG