2. Immunology/Inflammation
  3. Complement System
  4. Factor B-IN-5-1

Factor B-IN-5 is an orally active complement factor B (CFB) inhibitor. Factor B-IN-5 alleviates kidney damage in diabetes nephropathy by inhibiting the over activation of complement system and improving mitochondrial function. Factor B-IN-5 can improve renal tubulointerstitial inflammation and fibrosis. Factor B-IN-5 can be used for research on diabetic nephropathy.

For research use only. We do not sell to patients.

Factor B-IN-5-1 Chemical Structure

Factor B-IN-5-1 Chemical Structure

CAS No. : 1644670-23-4

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Factor B-IN-5-1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Factor B-IN-5 is an orally active complement factor B (CFB) inhibitor. Factor B-IN-5 alleviates kidney damage in diabetes nephropathy by inhibiting the over activation of complement system and improving mitochondrial function. Factor B-IN-5 can improve renal tubulointerstitial inflammation and fibrosis. Factor B-IN-5 can be used for research on diabetic nephropathy[1].

In Vivo

Factor B-IN-5 (20 and 60 mg/kg; i.g.; twice daily; for 10 weeks) improves interstitial inflammation of renal tubules and reduces kidney damage in male diabetic db/db C57BL/6J mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male diabetic db/db C57BL/6J mice (C57BL/6J-LepRdb/db) (6 weeks)[1]
Dosage: 20 and 60 mg/kg
Administration: Oral gavage (i.g.); twice daily for 10 weeks
Result: Significantly reduced the level of uACR.
Significantly improved renal tubulointerstitial fibrosis and atrophy.
Significantly reduced the thickness of glomerular basement membrane (GBM).
Reduced the expression of inflammatory markers Kim-1 and IL-1β.
Improved mitochondrial morphology and dynamics and upregulated the expression of Mfn2 and Prkn.
Might exert its effect by regulating CASP3 and DPP4.
Molecular Weight

392.49

Formula

C24H28N2O3
CAS No.
SMILES

CC1=CC(OC)=C(CN2CC[C@@H](C)C[C@H]2C3=CC=C(C(O)=O)C=C3)C4=C1NC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Factor B-IN-5-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Factor B-IN-5-11644670-23-4Complement SystemCFBinflammationdiabetic nephropathymitochondriadb/db micediabetes mellituInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Factor B-IN-5-1
Cat. No.:
HY-174913
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.