COX-2/15-LOX-IN-7

Cat. No.: HY-179021: Data Sheet Handling Instructions
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COX-2/15-LOX-IN-7 is a potent and selective dual inhibitor of COX-2 and 15-LOX with IC₅₀ values of 0.022 and 1.19 μM. COX-2/15-LOX-IN-7 also inhibits COX-1 with an IC₅₀ value of 28.081μM. COX-2/15-LOX-IN-7 has low cytotoxicity against human colorectal cancer HT-29 and HCT116 cell lines (IC₅₀ >100μM for both). COX-2/15-LOX-IN-7 exhibits non-ulcerogenic performance. COX-2/15-LOX-IN-7 can be used for the research of cancer.

For research use only. We do not sell to patients.

COX-2/15-LOX-IN-7 Chemical Structure

CAS No. : 1860810-23-6

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•Related Small Molecules:

•Related Proteins:

View All COX Isoform Specific Products:

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COX COX-1 COX-2 COX-3

View All Lipoxygenase Isoform Specific Products:

View All Isoforms

5-LOX 12-LOX 15-LOX

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

COX-2

0.022 μM (IC₅₀)

15-LOX

1.19 μM (IC₅₀)

COX-1

28.081 μM (IC₅₀)

In Vivo

COX-2/15-LOX-IN-7 (Compound 4a) (10 mg/kg, p.o., daily for 3 days) exhibits non-ulcerogenic property in the rats gastric ulcerogenic liability assay with an ulcer index of 0^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

366.38

Formula

C₂₂H₁₇F₃N₂

CAS No.

1860810-23-6

SMILES

FC(F)(F)C(C=C1)=CC=C1C(CC(C2=CC=CC=C2)=N3)N3C4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Abdullah D, et al. Pioneering 1,3,5-triaryl pyrazolines as promising dual inhibitors of COX-2 and 15-LOX endowed with potent anticancer activity: design, synthesis, and in silico study. Bioorg Chem. 2025 Oct 12;166:109081.

COX-2/15-LOX-IN-7 Related Classifications

Cancer

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The molarity calculator equation

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2/15-LOX-IN-71860810-23-6COXLipoxygenaseCyclooxygenaseLOXCOX-2COX-115-LOXHT-29HCT116ulcerogeniccolorectal cancerInhibitorinhibitorinhibit

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