2. Neuronal Signaling
  3. AAK1
  4. AAK1-IN-10

AAK1-IN-10 (Compound 1-2) is an AAK1 inhibitor. AAK1-IN-10 has significant AAK1 enzyme inhibitory activity (IC50: 9.62 nM). AAK1-IN-10 mainly exerts its effects by inhibiting the activity of connexin-associated kinase 1 (AAK1). AAK1-IN-10 has low cardiotoxicity (IC50 = 13.7 μM). AAK1-IN-10 can be used in the study of diabetic neuropathy and postherpetic pain.

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AAK1-IN-10 Chemical Structure

AAK1-IN-10 Chemical Structure

CAS No. : 3083494-45-2

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AAK1-IN-10 Related Antibodies

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Description

AAK1-IN-10 (Compound 1-2) is an AAK1 inhibitor. AAK1-IN-10 has significant AAK1 enzyme inhibitory activity (IC50: 9.62 nM). AAK1-IN-10 mainly exerts its effects by inhibiting the activity of connexin-associated kinase 1 (AAK1). AAK1-IN-10 has low cardiotoxicity (IC50 = 13.7 μM). AAK1-IN-10 can be used in the study of diabetic neuropathy and postherpetic pain[1].

Molecular Weight

417.40

Formula

C19H23F4N3O3
CAS No.
SMILES

FC(F)C1=NC=CC(C2=CC=C(OC[C@](N)(C)C[C@](O)(C)CO)C(C(F)F)=N2)=C1
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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AAK1-IN-10 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AAK1-IN-103083494-45-2AAK1Adaptor-associated Kinase 1AP2-associated kinase 1CHO cellsHergICR mice,SD ratsInhibitorinhibitorinhibit

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