ETK Antibody (YA4755)

ETK Antibody (YA4755) is a mouse-derived and non-conjugated monoclonal antibody, targeting to ETK. It can be applicated for WB, ELISA assays, in the background of human.

ETK is a non-receptor tyrosine kinase that plays central yet diverse modulatory roles in signaling processes regulating actin reorganization, cell migration, proliferation, survival, adhesion, and apoptosis. It participates in transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors, and integrins—inducing tyrosine phosphorylation of BCAR1 upon integrin regulation. Its activation by integrins is mediated by PTK2/FAK1, a key player in integrin signaling for actin cytoskeleton and motility control. ETK is critical for TNF-induced angiogenesis and implicated in TEK/FLT1 receptor signaling (essential for angiogenesis). It enables STAT3 phosphorylation (a differentiation-related transcription factor) and IL6-induced differentiation. ETK also programs adaptive cytoprotection against extracellular stress in salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. Potential roles include endocytosis regulation via interaction with endosomal protein RUFY1, hematopoietic cell growth/differentiation, and signal transduction in endocardial/arterial endothelial cells.

P51813

Predicted band size: 78 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human Bmx expressed in E. Coli.