2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. GGTase

GGTase

Geranylgeranyl Transferase

GGTase belongs to the family of isoprenyltransferases. It can transfer the geranylgeranyl group of GGPP to the cysteine residues of specific proteins. This post-translational modification can change the properties and functions of proteins, affecting their intracellular localization, stability, and interactions with other molecules, etc. GGTase is involved in cell signal transduction. By geranylgeranylating small G proteins, it can activate downstream signaling pathways, thus regulating processes such as cell proliferation and differentiation. In addition, GGTase is also involved in vesicle transport and the regulation of the cytoskeleton organization, which can alter cell morphology and migration ability. Abnormalities in its function or changes in its expression are closely related to tumors, neurodegenerative diseases, and cardiovascular diseases[1][2].

GGTase Isoform Specific Products:

GGTase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16229A
    GGTI-2154 hydrochloride
    		Inhibitor 98.93%
    GGTI-2154 hydrochloride is a potent and selective inhibitor geranylgeranyltransferase I (GGTase I), with an IC50 of 21 nM. GGTI-2154 hydrochloride shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 hydrochloride can be used for the research of cancer.
    GGTI-2154 hydrochloride
  • HY-161573
    BAY-593
    		Inhibitor 99.94%
    BAY-593 is an orally active GGTase-I inhibitor. BAY-593 can block YAP1/TAZ signaling in animals and has antitumor activity.
    BAY-593
  • HY-12369
    GGTI-2133
    		Inhibitor 98.50%
    GGTI-2133, a peptidomimetic, is a selective geranylgeranyltransferase I (GGTase-I) inhibitor with an IC50 of 38 nM. GGTI-2133 shows 140-fold selectivity over farnesyltransferase (FTase) (IC50 of 5.4 μM). GGTI-2133 inhibits the geranylation of Rap-1A with an IC50 of 10 μM. GGTI-2133 can be used for the study of eosinophilic airway inflammation such as asthma.
    GGTI-2133
  • HY-161573A
    (7S)-BAY-593
    		Inhibitor 99.61%
    (7S)-BAY-593 is the S-enantiomer of BAY-593 (HY-161573). BAY-593 is an orally active GGTase-I inhibitor. BAY-593 can block YAP1/TAZ signaling in animals and has antitumor activity.
    (7S)-BAY-593
  • HY-12369A
    GGTI-2133 TFA
    		Inhibitor
    GGTI-2133 TFA, a peptidomimetic, is a selective geranylgeranyltransferase I (GGTase-I) inhibitor with an IC50 of 38 nM. GGTI-2133 TFA shows 140-fold selectivity over farnesyltransferase (FTase) (IC50 of 5.4 μM). GGTI-2133 TFA inhibits the geranylation of Rap-1A with an IC50 of 10 μM. GGTI-2133 TFA can be used for the study of eosinophilic airway inflammation such as asthma.
    GGTI-2133 TFA
  • HY-161573B
    BAY-593 hydrochloride
    		Inhibitor
    BAY-593 (hydrochloride) is an orally active GGTase-I inhibitor. BAY-593 (hydrochloride) can block YAP1/TAZ signaling in animals and has antitumor activity.
    BAY-593 hydrochloride
  • HY-U00327
    Prenyl-IN-1
    		Inhibitor
    Prenyl-IN-1 is a protein prenylation inhibitor, especially a geranylgeranyltransferase (GGT) or a farnesyltransferase (FT) inhibitor, exhibiting potent activity against oxidative stress, and particularly in the treatment of Parkinson's Disease.
    Prenyl-IN-1
GGTase Isoform Comparison

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