GGTI-2133 TFA

Cat. No.: HY-12369A: Data Sheet Handling Instructions
FAQs
Technical Support

GGTI-2133 TFA, a peptidomimetic, is a selective geranylgeranyltransferase I (GGTase-I) inhibitor with an IC₅₀ of 38 nM. GGTI-2133 TFA shows 140-fold selectivity over farnesyltransferase (FTase) (IC₅₀ of 5.4 μM). GGTI-2133 TFA inhibits the geranylation of Rap-1A with an IC₅₀ of 10 μM. GGTI-2133 TFA can be used for the study of eosinophilic airway inflammation such as asthma.

For research use only. We do not sell to patients.

GGTI-2133 TFA Chemical Structure

CAS No. : 1217480-14-2

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of GGTI-2133 TFA:

GGTI-2133

Other Forms of GGTI-2133 TFA:

GGTI-2133 In-stock

1 Publications Citing Use of MCE GGTI-2133 TFA

•Cell Rep. 2025 Mar 5;44(3):115397. [Abstract]

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All GGTase Isoform Specific Products:

View All Isoforms

GGTase I

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

GGTI-2133 (5 mg/kg; intraperitoneal injection; once a day; for 10 days) TFA inhibits infiltration of inflammatory cells into airways in mouse experimental asthma^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male BALB/c mice (8 weeks of age) were actively sensitized byintraperitoneal injections of 8 ug ovalbumin with 2 mg Imject Alum on days 0 and 5^[2].
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; once a day; for 10 days from Day 11 to Day 20
Result:	Inhibited the antigen-induced eosinophil infiltration into airways almost completely.

Molecular Weight

570.56

Formula

C₂₉H₂₉F₃N₄O₅

CAS No.

1217480-14-2

SMILES

CC(C)C[C@@H](C(O)=O)NC(C1=CC=C(NCC2=CN=CN2)C=C1C3=C4C=CC=CC4=CC=C3)=O.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Vasudevan A, et al., Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I. J Med Chem. 1999 Apr 22;42(8):1333-40. [Content Brief]

[2]. Chiba Y, et al. GGTI-2133, an inhibitor of geranylgeranyltransferase, inhibits infiltration of inflammatory cells into airways in mouse experimental asthma. Int J Immunopathol Pharmacol. 2009 Oct-Dec;22(4):929-35. [Content Brief]

GGTI-2133 TFA Related Classifications

Inflammation/Immunology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GGTI-21331217480-14-2GGTI2133GGTI 2133GGTaseGeranylgeranyl TransferasepeptidomimeticGGTase-IasthmaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *