LRRFIP1 Antibody (YA5242)

LRRFIP1 Antibody (YA5242) is a mouse-derived and non-conjugated monoclonal antibody, targeting to LRRFIP1. It can be applicated for WB assays, in the background of human, mouse.

LRRFIP1, functioning as a transcriptional repressor, exhibits a preference for binding to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and is implicated in the potential regulation of TNF, EGFR, and PDGFA expression. This regulatory role extends to the control of smooth muscle cell proliferation following artery injury, achieved through the repression of PDGFA. Furthermore, LRRFIP1 demonstrates the capacity to bind double-stranded RNA. It plays a positive role in Toll-like receptor (TLR) signaling in response to agonists, likely by competitively interacting with the negative FLII regulator for MYD88-binding. Existing as a homodimer, LRRFIP1 may also form higher-order oligomers, and it interacts with FLII and MYD88, competing with FLII for MyD88-binding, even in the absence of lipopolysaccharide (LPS).

Q32MZ4

Observed band size: 160 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse

WB: 1:1000

WB

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human LRRFIP1 protein fragments expressed in E.coli.