2. Metabolic Enzyme/Protease Apoptosis NF-κB Immunology/Inflammation
  3. MMP Apoptosis Reactive Oxygen Species (ROS)
  4. MMP-9-IN-12

MMP-9-IN-12 is a matrix metalloproteinase-9 (MMP-9) inhibitor with an IC50 of 6.57 μM. MMP-9-IN-12 shows an IC50 value of 1.54 μM for HCT-116 cells. MMP-9-IN-12 induces cell apoptosis, ROS production and mitochondrial depolarization. MMP-9-IN-12 inhibits cells migration and disrupts cell cycle progression. MMP-9-IN-12 can be used for the research of colorectal cancer (CRC).

For research use only. We do not sell to patients.

MMP-9-IN-12

MMP-9-IN-12 Chemical Structure

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MMP-9-IN-12 Related Antibodies

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

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Description

MMP-9-IN-12 is a matrix metalloproteinase-9 (MMP-9) inhibitor with an IC50 of 6.57 μM. MMP-9-IN-12 shows an IC50 value of 1.54 μM for HCT-116 cells. MMP-9-IN-12 induces cell apoptosis, ROS production and mitochondrial depolarization. MMP-9-IN-12 inhibits cells migration and disrupts cell cycle progression. MMP-9-IN-12 can be used for the research of colorectal cancer (CRC)[1].

IC50 & Target[1]

MMP-9

6.57 μM (IC50)

In Vitro

MMP-9-IN-12 (compound 10 g) displays an IC50 value of 1.54 μM in HCT-116 cancer cell line while maintaining moderate activity of 14.41-24.35 μM in the remaining cancer cell lines[1].
MMP-9-IN-12 (0.77-3.08 μM, 48 h) induces apoptosis, ROS production and mitochondrial depolarization, in HCT-116 cells[1].
MMP-9-IN-12 (0.77-3.08 μM, 48 h) dose-dependently decreases the number of colony formations in HCT-116 cells[1].
MMP-9-IN-12 (0.77-3.08 μM, 48 h) reduces cell population in the S and G2 phases while increasing in the G0/G1 phase in HCT-116 cells[1].
MMP-9-IN-12 (0.77-3.08 μM, 48 h) reduces MMP9 expression in HCT-116 cells[1].
MMP-9-IN-12 (0.77-3.08 μM, 48 h) inhibits cells migration in HCT-116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MMP-9-IN-12 Related Antibodies

Apoptosis Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.77, 1.54 and 3.08 μM
Incubation Time: 48 h
Result: Increased apoptosis in a dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.77, 1.54 and 3.08 μM
Incubation Time: 48 h
Result: Reduced cell population in the S and G2 phases while increasing in the G0/G1 phase.

Western Blot Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.77, 1.54 and 3.08 μM
Incubation Time: 48 h
Result: Reduced MMP9 expression.
Molecular Weight

517.96

Formula

C28H24ClN3O5
SMILES

COC1=C(OCC2=NN=C(C3=CC=CC=C3Cl)O2)C(C4)=C(C=C1)CC5N4CCC6=CC7=C(OCO7)C=C56
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MMP-9-IN-12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMP-9-IN-12MMPApoptosisReactive Oxygen Species (ROS)Matrix metalloproteinasesMatrix metalloproteinaseHCT-116ROSCRCInhibitorinhibitorinhibit

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