2. Cell Cycle/DNA Damage
  3. Telomerase
  4. TRF1-TIN2 interaction-IN-1

TRF1-TIN2 interaction-IN-1 (Compound 40) is a TRF1-TIN2 interaction inhibitor. TRF1-TIN2 interaction-IN-1 binds to the TRFH domain of TRF1 (KD = 29 μM) and competitively inhibits the binding of the TIN2 peptide (IC50 = 67 μM). TRF1-TIN2 interaction-IN-1 disrupts the interaction between TRF1 and TIN2 by occupying the hotspot region of the TRF1-TIN2 binding interface. TRF1-TIN2 interaction-IN-1 can expel TRF 1 from the shelterin complex and can be used to study shelterin-related cancers.

For research use only. We do not sell to patients.

TRF1-TIN2 interaction-IN-1 Chemical Structure

TRF1-TIN2 interaction-IN-1 Chemical Structure

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TRF1-TIN2 interaction-IN-1 Related Antibodies

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Description

TRF1-TIN2 interaction-IN-1 (Compound 40) is a TRF1-TIN2 interaction inhibitor. TRF1-TIN2 interaction-IN-1 binds to the TRFH domain of TRF1 (KD = 29 μM) and competitively inhibits the binding of the TIN2 peptide (IC50 = 67 μM). TRF1-TIN2 interaction-IN-1 disrupts the interaction between TRF1 and TIN2 by occupying the hotspot region of the TRF1-TIN2 binding interface. TRF1-TIN2 interaction-IN-1 can expel TRF 1 from the shelterin complex and can be used to study shelterin-related cancers[1].

Molecular Weight

374.41

Formula

C19H18O6S
SMILES

OS(C1=CC=C(OCC2=CC(OC)=CC(OC)=C2)C3=C1C=CC=C3)(=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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TRF1-TIN2 interaction-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRF1-TIN2 interaction-IN-1TelomeraseShelterincancerproteintelomeres,DNAInhibitorinhibitorinhibit

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