Kathon 886MW (14.5% in water)

Cat. No.: HY-W017982 Purity: 97.0%: Data Sheet
COA

SDS
Handling Instructions
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Kathon 886MW (14.5% in water) is an efficient broad-spectrum biocide suitable for various metalworking fluids.

For research use only. We do not sell to patients.

Kathon 886MW (14.5% in water) Chemical Structure

CAS No. : 55965-84-9

Size	Stock	Quantity
100 g	In-stock	Estimated Time of Arrival: December 31
500 g	In-stock	Estimated Time of Arrival: December 31
1 kg	In-stock	Estimated Time of Arrival: December 31

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Purity & Documentation
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Description

Kathon 886MW (14.5% in water) is an efficient broad-spectrum biocide suitable for various metalworking fluids^[1]^[2].

Molecular Weight

264.75

Formula

C₈H₉ClN₂O₂S₂

CAS No.

55965-84-9

Appearance

Liquid (Density: 1.19 g/cm³)

Color

Colorless to light yellow

SMILES

O=C1C=CSN1C.O=C2C=C(SN2C)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (755.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7771 mL	18.8857 mL	37.7715 mL
5 mM	0.7554 mL	3.7771 mL	7.5543 mL
10 mM	0.3777 mL	1.8886 mL	3.7771 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (18.89 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (18.89 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (18.89 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (248 KB)

Handling Instructions (2659 KB)

References

[1]. Springle W R. Evaluation of latex paint preservatives: comparative method and a quantitative treatment of bacterial behavior in paint test systems[J]. Industrial & Engineering Chemistry Product Research and Development, 1983, 22(1): 61-67.

[2]. de Groot A C, et al. Kathon® CG: cosmetic allergy and patch test sensitization[J]. Contact dermatitis, 1985, 12(2): 76-80.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7771 mL	18.8857 mL	37.7715 mL	94.4287 mL
	5 mM	0.7554 mL	3.7771 mL	7.5543 mL	18.8857 mL
	10 mM	0.3777 mL	1.8886 mL	3.7771 mL	9.4429 mL
	15 mM	0.2518 mL	1.2590 mL	2.5181 mL	6.2952 mL
	20 mM	0.1889 mL	0.9443 mL	1.8886 mL	4.7214 mL
	25 mM	0.1511 mL	0.7554 mL	1.5109 mL	3.7771 mL
	30 mM	0.1259 mL	0.6295 mL	1.2590 mL	3.1476 mL
	40 mM	0.0944 mL	0.4721 mL	0.9443 mL	2.3607 mL
	50 mM	0.0755 mL	0.3777 mL	0.7554 mL	1.8886 mL
	60 mM	0.0630 mL	0.3148 mL	0.6295 mL	1.5738 mL
	80 mM	0.0472 mL	0.2361 mL	0.4721 mL	1.1804 mL
	100 mM	0.0378 mL	0.1889 mL	0.3777 mL	0.9443 mL