2. Neuronal Signaling
  3. Cholinesterase (ChE) Amyloid-β Tau Protein
  4. BChE-IN-41

BChE-IN-41 is a highly selective Butyrylcholinesterase (BChE) inhibitor (IC50 =12 nM, Ki = 6.6 nM). BChE-IN-41 has high brain penetration with a brain-to-plasma ratio of 9.0. BChE-IN-41 has pro-cognitive effects on mice with AD-like symptoms induced by Scopolamine (HY-N0296) and Aβ1-42.

For research use only. We do not sell to patients.

BChE-IN-41 Chemical Structure

BChE-IN-41 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

BChE-IN-41 Related Antibodies

Top Publications Citing Use of Products

View All Cholinesterase (ChE) Isoform Specific Products:

View All Isoforms
AChE BChE

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BChE-IN-41 is a highly selective Butyrylcholinesterase (BChE) inhibitor (IC50 =12 nM, Ki = 6.6 nM). BChE-IN-41 has high brain penetration with a brain-to-plasma ratio of 9.0. BChE-IN-41 has pro-cognitive effects on mice with AD-like symptoms induced by Scopolamine (HY-N0296) and Aβ1-42[1].

IC50 & Target

hAChE

22110 nM (IC50)

In Vitro

BChE-IN-41 (Compound (R)-(−)-3) (5 μM, 48 h) exhibits neuroprotective activity by diminishing Aβ1−42-induce SH-SY5Y cells death[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BChE-IN-41 Related Antibodies

Cell Viability Assay[1]

Cell Line: HepG2 cells, SH-SY5Y cells
Concentration: 1 μM, 5 μM, 10 μM, 20 μM, 50 μM, 100 μM
Incubation Time: 48 h
Result: Had comparable cytotoxicity profiles in both HepG2 cells and SH-SY5Y cells.

Cell Cytotoxicity Assay[1]

Cell Line: SH-SY5Y cells
Concentration: 2.5 μM, 5 μM
Incubation Time: 48 h
Result: Reversed Aβ toxicity and reduced cell death at 5 μM; its effect was not significant at 2.5 μM.
In Vivo

BChE-IN-41 (Compound (R)-(−)-3) (10-100 mg/kg, i.g, sing dose) is highly potent and has high brain penetration and low toxicity in wild-type Balb/c mice, with no histopathological changes in mice[1].
BChE-IN-41 (1-10 mg/kg, i.p, sing dose) improves contextual memory deficits and recognition memory deficits in adult male CD-1 mice induced by scopolamine[1].
BChE-IN-41 (10 mg/kg, i.p, at the corresponding doses for 14 days) improves learning ability and cognitive function in ICR male mice induced by Aβ1-42 oligomers[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female and male wild-type Balb/c mice (3 months)[1]
Dosage: 10 mg/kg, 100 mg/kg
Administration: Oral gavage (i.g.), sing dose
Result: Exhibited high brain penetration with a brain-to-plasma ratio of 9.0.
Caused no mortality or tissue lesions in mice, and no abnormalities were found in histological examination.
Caused steady weight gain with no signs of acute toxicity.
Animal Model: Scopolamine (HY-N0296) (1 mg/kg, s.c) induced AD model in adult male CD-1 mice (18-22 g)[1]
Dosage: 1 mg/kg, 10 mg/kg
Administration: Intraperitoneal injection (i.p.), sing dose
Result: Prolonged the latency to enter the dark chamber and improved the contextual memory deficit.
Demonstrated prolonged step-through latency compared to mice treated with scopolamine only.
Enhanced preference for novel objects and increased the discrimination index (DI) and reversed the recognition memory deficit.
Animal Model: Aβ1-42 oligomers (10 µg per mouse, i.c.v) induced AD-like cognitive deficits model in ICR male mice (8-10 weeks, 18−20 g)[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.), at the corresponding doses for 14 days.
Result: Caused no motor impairment in the rotarod test (6/18/24 rpm).
Resulted in shorter escape latency and shorter distance to reach the target area, and improved Aβ1-42-induced cognitive deficits.
Molecular Weight

394.53

Formula

C23H26N2O2S
SMILES

CN(S(=O)(C1=CC=C(C=CC=C2)C2=C1)=O)C[C@@H](C3)CCN3CC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

BChE-IN-41 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BChE-IN-41Cholinesterase (ChE)Amyloid-βTau Proteinβ-amyloid peptideAβAbetaAlzheimer’s DiseaseHepG2 cellsSH-SY5Y cellsBALB/C miceICR miceCD-1 micehBChEInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
BChE-IN-41
Cat. No.:
HY-174381
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.