2. Protein Tyrosine Kinase/RTK Apoptosis
  3. Src Apoptosis
  4. Lck-IN-4

Lck-IN-4 (Compound A-1) is a protein tyrosine kinase Lck inhibitor with an IC50 of 2  nM. Lck-IN-4 significantly inhibits YAP tyrosine phosphorylation and activity and induces apoptosis in cholangiocarcinoma CCA cells. Lck-IN-4 is cytotoxic in CCA tumor-derived organoids with elevated YAP activity Lck-IN-4 can be used for cancers like cholangiocarcinoma (CCA) research.

For research use only. We do not sell to patients.

Lck-IN-4

Lck-IN-4 Chemical Structure

CAS No. : 1326278-38-9

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Lck-IN-4 Related Antibodies

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Lck Fyn Blk Fgr Hck Lyn Yes SRC-3

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Description

Lck-IN-4 (Compound A-1) is a protein tyrosine kinase Lck inhibitor with an IC50 of 2  nM. Lck-IN-4 significantly inhibits YAP tyrosine phosphorylation and activity and induces apoptosis in cholangiocarcinoma CCA cells. Lck-IN-4 is cytotoxic in CCA tumor-derived organoids with elevated YAP activity Lck-IN-4 can be used for cancers like cholangiocarcinoma (CCA) research[1].

Molecular Weight

621.77

Formula

C36H43N7O3
CAS No.
SMILES

CC1=NC=CN2C([C@H]3CC[C@H](N4CCN(CC4)C)CC3)=NC(C5=CC(OC)=C(C=C5)NC(C6=CC7=C(OC)C=CC=C7N6C)=O)=C12
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Lck-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lck-IN-41326278-38-9SrcApoptosisLckYAP tyrosine phosphorylationHuCCT-1 cellsCholangiocarcinomaCCAInhibitorinhibitorinhibit

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