2. Apoptosis
  3. c-Myc
  4. FUBP1-IN-2

FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases p21 mRNA and protein expression, and depletes intracellular polyamines.

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FUBP1-IN-2 Chemical Structure

FUBP1-IN-2 Chemical Structure

CAS No. : 1242862-71-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

FUBP1-IN-2 Related Antibodies

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  • Purity & Documentation

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Description

FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases p21 mRNA and protein expression, and depletes intracellular polyamines[1].

Cellular Effect
Cell Line Type Value Description References
CHO-K1 EC50
> 40 μM
Compound: 9; 0754479
Inhibition of spermidine uptake chinese hamster CHO-K1 cells assessed as decrease in cell growth by measuring cellular ATP content measured after 48 hrs in presence of DFMO and spermidine by ATPlite assay
Inhibition of spermidine uptake chinese hamster CHO-K1 cells assessed as decrease in cell growth by measuring cellular ATP content measured after 48 hrs in presence of DFMO and spermidine by ATPlite assay
[PMID: 36382923]
CHO-K1 EC50
8 μM
Compound: 9; 0754479
Inhibition of polyamine uptake in chinese hamster CHO-K1 cells assessed as rescue of Ant44-induced toxicity by measuring cellular ATP content measured after 48 hrs in presence of Ant44 and aminoguanidine by ATPlite assay
Inhibition of polyamine uptake in chinese hamster CHO-K1 cells assessed as rescue of Ant44-induced toxicity by measuring cellular ATP content measured after 48 hrs in presence of Ant44 and aminoguanidine by ATPlite assay
[PMID: 36382923]
L3.6pl IC50
16.8 μM
Compound: 9; 0754479
Cytotoxicity against human L3.6pl cells cells assessed as inhibition of cell growth measured after 72 hrs by ATPlite assay
Cytotoxicity against human L3.6pl cells cells assessed as inhibition of cell growth measured after 72 hrs by ATPlite assay
[PMID: 36382923]
In Vitro

FUBP1-IN-2 (compound 9) does not inhibit 3 H-spermidine uptake yet works synergistically with Eflornithine.html" class="link-product" target="_blank">Eflornithine (HY-B0744) to limit cell growth in the presence of exogenous spermidine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FUBP1-IN-2 Related Antibodies
Molecular Weight

479.96

Formula

C26H26ClN3O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

COC1=CC=C(C=C1)C(NC2=C(C=C(C=C2)N3CCN(CC3)C4=C(C=CC(Cl)=C4)C)C(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (243.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0835 mL 10.4175 mL 20.8351 mL
5 mM 0.4167 mL 2.0835 mL 4.1670 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0835 mL 10.4175 mL 20.8351 mL 52.0877 mL
5 mM 0.4167 mL 2.0835 mL 4.1670 mL 10.4175 mL
10 mM 0.2084 mL 1.0418 mL 2.0835 mL 5.2088 mL
15 mM 0.1389 mL 0.6945 mL 1.3890 mL 3.4725 mL
20 mM 0.1042 mL 0.5209 mL 1.0418 mL 2.6044 mL
25 mM 0.0833 mL 0.4167 mL 0.8334 mL 2.0835 mL
30 mM 0.0695 mL 0.3473 mL 0.6945 mL 1.7363 mL
40 mM 0.0521 mL 0.2604 mL 0.5209 mL 1.3022 mL
50 mM 0.0417 mL 0.2084 mL 0.4167 mL 1.0418 mL
60 mM 0.0347 mL 0.1736 mL 0.3473 mL 0.8681 mL
80 mM 0.0260 mL 0.1302 mL 0.2604 mL 0.6511 mL
100 mM 0.0208 mL 0.1042 mL 0.2084 mL 0.5209 mL
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FUBP1-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FUBP1-IN-21242862-71-0c-MycMycCHO-K1 cellsFUBP1far upstream binding protein 1FUBP1-FUSEp21polyaminesInhibitorinhibitorinhibit

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