2. Metabolic Enzyme/Protease Anti-infection
  3. Dihydroorotate Dehydrogenase SARS-CoV
  4. DHODH-IN-31

DHODH-IN-31 is a human dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.59 μM. DHODH-IN-31 exhibits antiviral activity. DHODH-IN-31 can be used for the research of infection, such as SARS-CoV-2.

For research use only. We do not sell to patients.

DHODH-IN-31

DHODH-IN-31 Chemical Structure

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Based on 1 publication(s) in Google Scholar

DHODH-IN-31 Related Antibodies

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Description

DHODH-IN-31 is a human dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.59 μM. DHODH-IN-31 exhibits antiviral activity. DHODH-IN-31 can be used for the research of infection, such as SARS-CoV-2[1].

IC50 & Target[1]

hDHODH

0.59 μM (IC50)

SARS-CoV-2

0.15 μM (EC50)

In Vitro

DHODH-IN-31 (Compound 10e) exhibits antiviral activity against SARS-CoV-2 with an EC50 of 0.15 μM[1].
DHODH-IN-31 shows CC50 values of 26 and 180 μM in Vero and SH-SY5Y cells[1].
DHODH-IN-31 (0.01-10 μM) inhibits SARS-CoV-2 viral replication in Calu-3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DHODH-IN-31 Related Antibodies
Molecular Weight

313.35

Formula

C20H15N3O
Appearance

Powder

SMILES

O=C1NC(NC2=CC(C3=CC=CC=C3)=CC=C2)=NC4=C1C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (398.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1913 mL 15.9566 mL 31.9132 mL
5 mM 0.6383 mL 3.1913 mL 6.3826 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1913 mL 15.9566 mL 31.9132 mL 79.7830 mL
5 mM 0.6383 mL 3.1913 mL 6.3826 mL 15.9566 mL
10 mM 0.3191 mL 1.5957 mL 3.1913 mL 7.9783 mL
15 mM 0.2128 mL 1.0638 mL 2.1275 mL 5.3189 mL
20 mM 0.1596 mL 0.7978 mL 1.5957 mL 3.9891 mL
25 mM 0.1277 mL 0.6383 mL 1.2765 mL 3.1913 mL
30 mM 0.1064 mL 0.5319 mL 1.0638 mL 2.6594 mL
40 mM 0.0798 mL 0.3989 mL 0.7978 mL 1.9946 mL
50 mM 0.0638 mL 0.3191 mL 0.6383 mL 1.5957 mL
60 mM 0.0532 mL 0.2659 mL 0.5319 mL 1.3297 mL
80 mM 0.0399 mL 0.1995 mL 0.3989 mL 0.9973 mL
100 mM 0.0319 mL 0.1596 mL 0.3191 mL 0.7978 mL
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DHODH-IN-31 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHODH-IN-31Dihydroorotate DehydrogenaseSARS-CoVDHODHSARS coronavirusdihydroorotate dehydrogenaseantiviralSARS-CoV-2infectionVeroSH-SY5YCalu-3Inhibitorinhibitorinhibit

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