2. MAPK/ERK Pathway Stem Cell/Wnt Apoptosis
  3. ERK Apoptosis
  4. Multi-target kinase inhibitor 5

Multi-target kinase inhibitor 5 (Compound 23) is an orally active ERK1/2 inhibitor (IC50 values are 3.04 nM and 1.57 nM, respectively). Multi-target kinase inhibitor 5 significantly inhibits cancer cell proliferation, migration and invasion, and induces cell apoptosis and cell cycle arrest. Multi-target kinase inhibitor 5 inhibits the phosphorylation of ERK1/2 and downregulates the activity of its downstream substrate RSK to exert anti-tumor effects. Multi-target kinase inhibitor 5 can be used in cancer research.

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Multi-target kinase inhibitor 5 Chemical Structure

Multi-target kinase inhibitor 5 Chemical Structure

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Multi-target kinase inhibitor 5 Related Antibodies

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Description

Multi-target kinase inhibitor 5 (Compound 23) is an orally active ERK1/2 inhibitor (IC50 values are 3.04 nM and 1.57 nM, respectively). Multi-target kinase inhibitor 5 significantly inhibits cancer cell proliferation, migration and invasion, and induces cell apoptosis and cell cycle arrest. Multi-target kinase inhibitor 5 inhibits the phosphorylation of ERK1/2 and downregulates the activity of its downstream substrate RSK to exert anti-tumor effects. Multi-target kinase inhibitor 5 can be used in cancer research[1].

Molecular Weight

416.83

Formula

C20H18ClFN4O3
SMILES

O=C(C1=CC2=C(C=C1)C=NC(NC3COC3)=N2)N[C@H](CO)C4=CC=C(C(F)=C4)Cl
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Multi-target kinase inhibitor 5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-target kinase inhibitor 5ERKApoptosisExtracellular signal regulated kinasesHT29 cellsColo205 cellsA375 cellsH358 cellsHepG2 cellsBalb/c miceInhibitorinhibitorinhibit

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HY-174128
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