2. Apoptosis
  3. Bcl-2 Family
  4. A-1211212

A-1211212 (BCL2-IN-1) is a potent Bcl-2 inhibitor. BCL2-IN-1 binds Bcl-2 with a Ki of <0.01 nM.

For research use only. We do not sell to patients.

A-1211212 Chemical Structure

A-1211212 Chemical Structure

CAS No. : 1257044-75-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
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200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

A-1211212 Related Antibodies

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  • Biological Activity

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Description

A-1211212 (BCL2-IN-1) is a potent Bcl-2 inhibitor. BCL2-IN-1 binds Bcl-2 with a Ki of <0.01 nM[1].

Molecular Weight

896.49

Formula

C47H54ClN7O7S
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(NS(=O)(C1=CC=C(NC[C@H]2CC[C@H](OC)CC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCN(CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)CC4)C=C3OC7=CN=C(NC=C8)C8=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (111.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1155 mL 5.5773 mL 11.1546 mL
5 mM 0.2231 mL 1.1155 mL 2.2309 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1155 mL 5.5773 mL 11.1546 mL 27.8865 mL
5 mM 0.2231 mL 1.1155 mL 2.2309 mL 5.5773 mL
10 mM 0.1115 mL 0.5577 mL 1.1155 mL 2.7887 mL
15 mM 0.0744 mL 0.3718 mL 0.7436 mL 1.8591 mL
20 mM 0.0558 mL 0.2789 mL 0.5577 mL 1.3943 mL
25 mM 0.0446 mL 0.2231 mL 0.4462 mL 1.1155 mL
30 mM 0.0372 mL 0.1859 mL 0.3718 mL 0.9296 mL
40 mM 0.0279 mL 0.1394 mL 0.2789 mL 0.6972 mL
50 mM 0.0223 mL 0.1115 mL 0.2231 mL 0.5577 mL
60 mM 0.0186 mL 0.0930 mL 0.1859 mL 0.4648 mL
80 mM 0.0139 mL 0.0697 mL 0.1394 mL 0.3486 mL
100 mM 0.0112 mL 0.0558 mL 0.1115 mL 0.2789 mL
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A-1211212 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A-12112121257044-75-9BCL2-IN-1A1211212A 1211212Bcl-2 Familycancerapoptosispro-apoptoticInhibitorinhibitorinhibit

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