DMRT1 Antibody (YA1226)

DMRT1 Antibody (YA1226) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1226), targeting DMRT1. DMRT1 Antibody (YA1226) can be used for IHC-P experiment in human background.

DMRT1 is a transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. It functions centrally in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, thereby driving spermatogonial development and enabling continuous sperm production. DMRT1 acts as both a transcriptional repressor and activator: it prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression, while activating spermatogonial differentiation genes like SOHLH1 to promote development. It also maintains postnatal sex determination by sustaining testis identity and preventing feminization through repression of female-promoting genes (e.g., FOXL2) and activation of male-specific genes. DMRT1 may function as a tumor suppressor. By similarity, it might play a minor role in oogenesis.

Q9Y5R6

Predicted band size: 39 kDa; Observed band size: 34 kDa

Affinity Purified

Non-conjugated

Unmodified

Epigenetics and Nuclear Signaling

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

IHC: 1/100-1/200

IHC-P

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.308.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human DMRT1