2. Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. VEGFR EGFR
  4. EGFR T790M/VEGFR-2-IN-1

EGFR T790M/VEGFR-2-IN-1 (Compound 6) is a dual EGFR T790M mutant (IC50=0.26 μM) and VEGFR-2 (IC50=0.95 μM) inhibitor. EGFR T790M/VEGFR-2-IN-1 blocks tumor cell proliferation and angiogenesis signaling pathways. EGFR T790M/VEGFR-2-IN-1 exhibits potent cytotoxicity against multiple cancer cell lines (HCT116, MCF-7, HepG2, A549; IC50=5.35-9.90 μM). EGFR T790M/VEGFR-2-IN-1 is promising for research of non-small cell lung cancer and solid tumors.

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EGFR T790M/VEGFR-2-IN-1

EGFR T790M/VEGFR-2-IN-1 Chemical Structure

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EGFR T790M/VEGFR-2-IN-1 Related Antibodies

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Description

EGFR T790M/VEGFR-2-IN-1 (Compound 6) is a dual EGFR T790M mutant (IC50=0.26 μM) and VEGFR-2 (IC50=0.95 μM) inhibitor. EGFR T790M/VEGFR-2-IN-1 blocks tumor cell proliferation and angiogenesis signaling pathways. EGFR T790M/VEGFR-2-IN-1 exhibits potent cytotoxicity against multiple cancer cell lines (HCT116, MCF-7, HepG2, A549; IC50=5.35-9.90 μM). EGFR T790M/VEGFR-2-IN-1 is promising for research of non-small cell lung cancer and solid tumors[1].

IC50 & Target

EGFRT790M

0.26 μM (IC50)

VEGFR2

0.95 μM (IC50)

Molecular Weight

465.45

Formula

C18H15N11O3S
SMILES

O=S(C1=CC=C(/N=N/C2=C3N=C(N)C(C#N)=C(C4=CC=CO4)N3N=C2N)C=C1)(/N=C(N)\N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR T790M/VEGFR-2-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR T790M/VEGFR-2-IN-1VEGFREGFRVascular endothelial growth factor receptorEpidermal growth factor receptorErbB-1HER1EGFR T790MVEGFR-2angiogenesisnon-small cell lung cancerInhibitorinhibitorinhibit

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EGFR T790M/VEGFR-2-IN-1
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