2. Neuronal Signaling Metabolic Enzyme/Protease
  3. Monoamine Oxidase Amylases
  4. MAO-B-IN-46

MAO-B-IN-46 (Compound 16) is a selective hMAO-B inhibitor (IC50: 26.8 nM), with weak activity against hMAO-A (IC50: 7.2054 μM). MAO-B-IN-46 (Compound 8) also acts as an α-amylase inhibitor (IC50: 19.46 μM). MAO-B-IN-46 exhibits certain neuroprotective effects and shows no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS free radicals, with IC50 values of 17.86 μM and 17.71 μM, respectively. MAO-B-IN-46 can be used in the research of neurodegenerative diseases such as Parkinson's disease, diabetes, and diseases related to oxidative stress resistance.

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MAO-B-IN-46

MAO-B-IN-46 Chemical Structure

CAS No. : 27052-20-6

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MAO-B-IN-46 Related Antibodies

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MAO-A MAO-B

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Description

MAO-B-IN-46 (Compound 16) is a selective hMAO-B inhibitor (IC50: 26.8 nM), with weak activity against hMAO-A (IC50: 7.2054 μM). MAO-B-IN-46 (Compound 8) also acts as an α-amylase inhibitor (IC50: 19.46 μM). MAO-B-IN-46 exhibits certain neuroprotective effects and shows no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS free radicals, with IC50 values of 17.86 μM and 17.71 μM, respectively. MAO-B-IN-46 can be used in the research of neurodegenerative diseases such as Parkinson's disease, diabetes, and diseases related to oxidative stress resistance[1][2].

IC50 & Target[1]

hMAO-A

7.2054 μM (IC50)

hMAO-B

26.8 nM (IC50)

Molecular Weight

256.68

Formula

C15H9ClO2
CAS No.
SMILES

C1=CC=C2C(=C1)C=C(C(=O)C3=CC=C(C=C3)Cl)O2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MAO-B-IN-46 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-4627052-20-6Monoamine OxidaseAmylasesMAOhuman gingival fibroblastsSH-SY5Y cellsPDdiabetesoxidative stressInhibitorinhibitorinhibit

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