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  4. POSH-IN-1

POSH-IN-1 (Compound 108) is an inhibitor for POSH polypeptide, that inhibits the ubiquitin ligase of POSH with an IC50 of 900 nM.

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POSH-IN-1 Chemical Structure

POSH-IN-1 Chemical Structure

CAS No. : 328960-84-5

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POSH-IN-1 Related Antibodies

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Description

POSH-IN-1 (Compound 108) is an inhibitor for POSH polypeptide, that inhibits the ubiquitin ligase of POSH with an IC50 of 900 nM[1].

Molecular Weight

289.28

Formula

C14H8FNO3S
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C1S/C(C(N1)=O)=C\C2=CC=C(C3=CC=C(F)C=C3)O2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (172.84 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4569 mL 17.2843 mL 34.5686 mL
5 mM 0.6914 mL 3.4569 mL 6.9137 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4569 mL 17.2843 mL 34.5686 mL 86.4215 mL
5 mM 0.6914 mL 3.4569 mL 6.9137 mL 17.2843 mL
10 mM 0.3457 mL 1.7284 mL 3.4569 mL 8.6421 mL
15 mM 0.2305 mL 1.1523 mL 2.3046 mL 5.7614 mL
20 mM 0.1728 mL 0.8642 mL 1.7284 mL 4.3211 mL
25 mM 0.1383 mL 0.6914 mL 1.3827 mL 3.4569 mL
30 mM 0.1152 mL 0.5761 mL 1.1523 mL 2.8807 mL
40 mM 0.0864 mL 0.4321 mL 0.8642 mL 2.1605 mL
50 mM 0.0691 mL 0.3457 mL 0.6914 mL 1.7284 mL
60 mM 0.0576 mL 0.2881 mL 0.5761 mL 1.4404 mL
80 mM 0.0432 mL 0.2161 mL 0.4321 mL 1.0803 mL
100 mM 0.0346 mL 0.1728 mL 0.3457 mL 0.8642 mL
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POSH-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

POSH-IN-1328960-84-5HIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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