2. Protein Tyrosine Kinase/RTK
  3. Src
  4. SRC-3-IN-2

SRC-3-IN-2 (SI-12 6c)is an orally active steroid receptor coactivator 3 (SRC-3) inhibitor. SRC-3-IN-2 has antitumor activity.

For research use only. We do not sell to patients.

SRC-3-IN-2 Chemical Structure

SRC-3-IN-2 Chemical Structure

CAS No. : 3074959-44-4

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SRC-3-IN-2 Related Antibodies

Top Publications Citing Use of Products

View All Src Isoform Specific Products:

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Lck Fyn Blk Hck Lyn Yes

  • Biological Activity

  • Purity & Documentation

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Description

SRC-3-IN-2 (SI-12 6c)is an orally active steroid receptor coactivator 3 (SRC-3) inhibitor. SRC-3-IN-2 has antitumor activity[1].

In Vitro

SRC-3-IN-2 IC50 value of MCF7 cell is 3.4 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SRC-3-IN-2 Related Antibodies
In Vivo


Pharmacokinetic Analysis in CD-1 mice Model[1]

Route Dose (mg/kg) AUClast (ng·h/mL) t1/2 (h) Tmax (h) Cmax (ng/mL) Clobs (mL·min/kg) F (%)
i.v. 1 737 22.5 0.033 1066 22 /
p.o. 10 1719 14.3 0.25 217 / 24.6

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

319.28

Formula

C15H12F3N5
CAS No.
Appearance

Solid

Color

Purple to purplish red

SMILES

CN1C2=CC(F)=C(F)C=C2N/C1=N\N=C(C3=CC=C(C=N3)F)/C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (78.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1320 mL 15.6602 mL 31.3205 mL
5 mM 0.6264 mL 3.1320 mL 6.2641 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1320 mL 15.6602 mL 31.3205 mL 78.3012 mL
5 mM 0.6264 mL 3.1320 mL 6.2641 mL 15.6602 mL
10 mM 0.3132 mL 1.5660 mL 3.1320 mL 7.8301 mL
15 mM 0.2088 mL 1.0440 mL 2.0880 mL 5.2201 mL
20 mM 0.1566 mL 0.7830 mL 1.5660 mL 3.9151 mL
25 mM 0.1253 mL 0.6264 mL 1.2528 mL 3.1320 mL
30 mM 0.1044 mL 0.5220 mL 1.0440 mL 2.6100 mL
40 mM 0.0783 mL 0.3915 mL 0.7830 mL 1.9575 mL
50 mM 0.0626 mL 0.3132 mL 0.6264 mL 1.5660 mL
60 mM 0.0522 mL 0.2610 mL 0.5220 mL 1.3050 mL
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SRC-3-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SRC-3-IN-23074959-44-4SrcSRCInhibitorMCF7Antitumorinhibitorinhibit

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