2. Neuronal Signaling
  3. OLIG2
  4. OLIG2-IN-1

OLIG2-IN-1 is a potent and selective oligodendrocyte transcription factor 2 (OLIG2) inhibitor. OLIG2-IN-1 directly and dose-dependently downregulates nuclear OLIG2 levels with an IC50 value of 0.88 μM. OLIG2-IN-1 exhibits strong anti-proliferative activity in U87 and U251 cells with IC50 values of 7.02 μM and 6.43 μM, respectively. OLIG2-IN-1 can be used for the research of cancer, such as glioblastoma multiforme.

For research use only. We do not sell to patients.

OLIG2-IN-1

OLIG2-IN-1 Chemical Structure

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OLIG2-IN-1 Related Antibodies

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Description

OLIG2-IN-1 is a potent and selective oligodendrocyte transcription factor 2 (OLIG2) inhibitor. OLIG2-IN-1 directly and dose-dependently downregulates nuclear OLIG2 levels with an IC50 value of 0.88 μM. OLIG2-IN-1 exhibits strong anti-proliferative activity in U87 and U251 cells with IC50 values of 7.02 μM and 6.43 μM, respectively. OLIG2-IN-1 can be used for the research of cancer, such as glioblastoma multiforme[1].

In Vitro

OLIG2-IN-1 (Compound B01) (10 μM, 12 h) exhibits the highest reduction in nuclear OLIG2 protein levels (75.87 %) in U87 cells[1].
OLIG2-IN-1 exhibits anti-proliferative activity in LN18 and C6 cells with IC50 values of 8.88 μM and 6.02 μM, respectively[1].
OLIG2-IN-1 (5 μM, 10 days) markedly suppresses colony formation in U87 cells[1].
OLIG2-IN-1 (0.02-10 μM, 12 h) dose-dependently reduces nuclear OLIG2 protein levels in U87 and U251 cells[1].
OLIG2-IN-1 protects OLIG2 from heat-induced denaturation in U87 cells and U251 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

OLIG2-IN-1 Related Antibodies

Western Blot Analysis[1]

Cell Line: U87 and U251 cells
Concentration: 0.02, 0.04, 0.08, 0.16, 0.31, 0.62, 1.25, 2.5, 5, 7.5 and 10 μM
Incubation Time: 12 h
Result: Reduced nuclear OLIG2 protein levels in a clear dose-dependent manner.
In Vivo

OLIG2-IN-1 (Compound B01) (50 mg/kg, i.p., every other day for 21 days) inhibits tumor growth in combination with Temozolomide (HY-17364) in a U87 xenograft mice models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: U87 xenograft mice models[1]
Dosage: 50 mg/kg, companied with 39 mg/kg of Temozolomide (HY-17364)
Administration: Intraperitoneally injection, every other day for 21 days
Result: Had stable body weights.
Reduced tumor volumes to 44.6 % and weight to 50.0 %.
Downregulated OLIG2 expression.
Molecular Weight

298.13

Formula

C11H9Cl2N5O
SMILES

NC1=NC=NC(NC(NC2=CC(Cl)=C(Cl)C=C2)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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OLIG2-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OLIG2-IN-1OLIG2Oligodendrocyte Transcription Factor 2Oligodendrocyte transcription factorU87U251Glioblastoma multiformeInhibitorinhibitorinhibit

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