2. MAPK/ERK Pathway Metabolic Enzyme/Protease
  3. JNK MMP
  4. JNK-IN-24

JNK-IN-24, a JNK inhibitor, is an anti-metastatic cancer agent. JNK-IN-24 downregulates JNK and MMP1 expression in Scrib knockdown induced cancer tissues. JNK-IN-24 promotes recovery from tumorous wing disc phenotype of ScribRNAi. JNK-IN-24 can be used for the study in various epithelial cell-derived cancers.

For research use only. We do not sell to patients.

JNK-IN-24

JNK-IN-24 Chemical Structure

CAS No. : 2226808-28-0

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JNK-IN-24 Related Antibodies

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Description

JNK-IN-24, a JNK inhibitor, is an anti-metastatic cancer agent. JNK-IN-24 downregulates JNK and MMP1 expression in Scrib knockdown induced cancer tissues. JNK-IN-24 promotes recovery from tumorous wing disc phenotype of ScribRNAi. JNK-IN-24 can be used for the study in various epithelial cell-derived cancers[1].

In Vivo

JNK-IN-24 (Compound 5f) (15-1000 μM, incorporated into a corn agar-based food medium) shows no lethality across the range of different doses on WT pupal development [1].
JNK-IN-24 (250-1000 μM, incorporated into a corn agar-based food medium, 36 h) rescues early pupal deaths to fully differentiated into pharate adults and promotes recovery from tumorous wing disc phenotype of ScribRNAi[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Knockdown Scrib in wing imaginal discs[1]
Dosage: 250, 1000 μM
Administration: Incorporated into a corn agar-based food medium for 36 h
Result: Exhibited significantly reduced Scrib transcript levels.
Decreased the levels of JNK and MMP1.
Restricted cancer cell migration from across anterior to posterior boundary.
Molecular Weight

360.79

Formula

C19H17ClO5
CAS No.
SMILES

O=C(C1=C(C)OC2=C(C(O)=CC(O)=C2)C1C3=CC=C(Cl)C=C3)OCC
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JNK-IN-24 Related Classifications

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Keywords:

JNK-IN-242226808-28-0JNKMMPc-Jun N-terminal kinaseMatrix metalloproteinasesMMP1epithelial cell-derived cancersInhibitorinhibitorinhibit

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