2. MAPK/ERK Pathway
  3. JNK
  4. JNK-IN-23

JNK-IN-23 (Compound K12) is an inhibitor of JNK. JNK-IN-23 inhibits the proliferation of MDA-MB-231 (GIC50: 30 nM). JNK-IN-23 blocks TNBC metastatic growth in vivo. JNK-IN-23 inhibits the growth of lung metastases by dual targeting of glutaminase-1 (GLS) and pyruvate dehydrogenase complex (PDHC).

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JNK-IN-23 Chemical Structure

JNK-IN-23 Chemical Structure

CAS No. : 1007786-48-2

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JNK-IN-23 Related Antibodies

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Description

JNK-IN-23 (Compound K12) is an inhibitor of JNK. JNK-IN-23 inhibits the proliferation of MDA-MB-231 (GIC50: 30 nM). JNK-IN-23 blocks TNBC metastatic growth in vivo. JNK-IN-23 inhibits the growth of lung metastases by dual targeting of glutaminase-1 (GLS) and pyruvate dehydrogenase complex (PDHC)[1].

Molecular Weight

382.50

Formula

C19H18N4OS2
CAS No.
SMILES

CC(C1=NC(SC(C)=C2C)=C2C(N1)=O)SC3=NC4=C(N=C3C)C=CC=C4
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JNK-IN-23 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK-IN-231007786-48-2JNKc-Jun N-terminal kinaseMDA-MB-231TNBCGLSPDHCanticancerInhibitorinhibitorinhibit

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