2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK12-IN-8

CDK12-IN-8 (Compound Cpd143) is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). CDK12-IN-8 inhibits CDK12-mediated phosphorylation of the C-terminal domain (CTD) serine 2 of RNA polymerase II, interfering with gene transcription elongation and DNA damage repair pathways. CDK12-IN-8 is promising for research of cancers with high CDK12 expression such as small cell lung cancer and triple-negative breast cancer.

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CDK12-IN-8 Chemical Structure

CDK12-IN-8 Chemical Structure

CAS No. : 2928619-86-5

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CDK12-IN-8 Related Antibodies

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Description

CDK12-IN-8 (Compound Cpd143) is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). CDK12-IN-8 inhibits CDK12-mediated phosphorylation of the C-terminal domain (CTD) serine 2 of RNA polymerase II, interfering with gene transcription elongation and DNA damage repair pathways. CDK12-IN-8 is promising for research of cancers with high CDK12 expression such as small cell lung cancer and triple-negative breast cancer[1].

IC50 & Target

CDK12

 

Molecular Weight

459.42

Formula

C21H20F3N7O2
CAS No.
SMILES

N#CC1=CC2=NN=C(N2C=C1)[C@@H](CCC3)C[C@@H]3NC4=NC=C(C(F)(F)F)C(OC5COC5)=N4
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CDK12-IN-8 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK12-IN-82928619-86-5CDKCyclin dependent kinaseorally activeCDK12RNA polymerase IIcancersInhibitorinhibitorinhibit

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