2. Cell Cycle/DNA Damage NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  3. Topoisomerase Reactive Oxygen Species (ROS) Apoptosis
  4. Topoisomerase II-IN-25

Topoisomerase II-IN-25 (Compound 6a) is a selective inhibitor of topoisomerase II and has no inhibitory activity on topoisomerase I. Topoisomerase II-IN-25 exhibits significant anti-PC-3 cell activity. Topoisomerase II-IN-25 significantly increases intracellular ROS levels, inducing oxidative stress. Topoisomerase II-IN-25 causes depolarization of mitochondrial membrane potential and promotes cell apoptosis. Topoisomerase II-IN-25 blocks PC-3 cells in the G2/M phase. Topoisomerase II-IN-25 can be used for the study of prostate cancer.

For research use only. We do not sell to patients.

Topoisomerase II-IN-25

Topoisomerase II-IN-25 Chemical Structure

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Topoisomerase II-IN-25 Related Antibodies

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Description

Topoisomerase II-IN-25 (Compound 6a) is a selective inhibitor of topoisomerase II and has no inhibitory activity on topoisomerase I. Topoisomerase II-IN-25 exhibits significant anti-PC-3 cell activity. Topoisomerase II-IN-25 significantly increases intracellular ROS levels, inducing oxidative stress. Topoisomerase II-IN-25 causes depolarization of mitochondrial membrane potential and promotes cell apoptosis. Topoisomerase II-IN-25 blocks PC-3 cells in the G2/M phase. Topoisomerase II-IN-25 can be used for the study of prostate cancer[1].

Molecular Weight

476.36

Formula

C26H22BrNO3
SMILES

O=C(C1=C(OCC=C)C=C(C2=CC=C(Br)C=C2)C(N3CC=C)=C1C4=C3C=CC=C4)OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Topoisomerase II-IN-25 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase II-IN-25TopoisomeraseReactive Oxygen Species (ROS)ApoptosisCarbazoleBreast cancerProstate cancerTopoisomerasesLead optimizationInhibitorinhibitorinhibit

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