2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. FGFR4-IN-18

FGFR4-IN-18 (compound 8z) is an inhibitor of FGFR4 and can be used in cancer research.

For research use only. We do not sell to patients.

FGFR4-IN-18

FGFR4-IN-18 Chemical Structure

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FGFR4-IN-18 Related Antibodies

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Description

FGFR4-IN-18 (compound 8z) is an inhibitor of FGFR4 and can be used in cancer research[1].

IC50 & Target

FGFR4[1]
Cellular Effect
Cell Line Type Value Description References
BaF3 IC50
1.2 nM
Compound: 8z
Antiproliferative activity against mouse BaF3 cells harboring wild type FGFR4 assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against mouse BaF3 cells harboring wild type FGFR4 assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 38348819]
BaF3 IC50
13.5 nM
Compound: 8z
Antiproliferative activity against mouse BaF3 cells harboring FGFR4 V550L mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against mouse BaF3 cells harboring FGFR4 V550L mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 38348819]
BaF3 IC50
64.5 nM
Compound: 8z
Antiproliferative activity against mouse BaF3 cells harboring FGFR4 V550M mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against mouse BaF3 cells harboring FGFR4 V550M mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 38348819]
BaF3 IC50
> 2000 nM
Compound: 8z
Antiproliferative activity against mouse BaF3 cells assessed as inhibition of cell growth
Antiproliferative activity against mouse BaF3 cells assessed as inhibition of cell growth
[PMID: 38348819]
HEK293 IC50
> 2000 nM
Compound: 8z
Cytotoxicity against HEK293 cells assessed as inhibition of cell growth
Cytotoxicity against HEK293 cells assessed as inhibition of cell growth
[PMID: 38348819]
Hep 3B2 IC50
15 nM
Compound: 8z
Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 38348819]
Huh-7 IC50
20.4 nM
Compound: 8z
Antiproliferative activity against FGF19/FGFR4 dependent human Huh-7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against FGF19/FGFR4 dependent human Huh-7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 38348819]
Molecular Weight

712.58

Formula

C32H35Cl2N9O6
SMILES

O=C(NC1=NC(C=O)=C(C=C1OCCN2CCOCC2)CN3C(CN(CC3)C)=O)NC4=CC(O[C@@H](C5=C(C=NC=C5Cl)Cl)C)=C(C=N4)C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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FGFR4-IN-18 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGFR4-IN-18FGFRFibroblast growth factor receptorcancerinhibitorInhibitorinhibit

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FGFR4-IN-18
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HY-162283
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