2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. Smurf1-IN-5

Smurf1-IN-5 (Compound cpd-6) is an allosteric SMAD ubiquitin regulatory factor 1 (SMURF1) inhibitor. Smurf1-IN-5 leads to a reduction in the ubiquitylation of substrates such as BMPR2 (bone morphogenetic protein receptor 2) and SMAD1, enhancing the BMP (bone morphogenetic protein) signaling pathway. Smurf1-IN-5 is promising for research of pulmonary arterial hypertension (PAH).

For research use only. We do not sell to patients.

Smurf1-IN-5 Chemical Structure

Smurf1-IN-5 Chemical Structure

CAS No. : 1824647-09-7

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Smurf1-IN-5 Related Antibodies

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Description

Smurf1-IN-5 (Compound cpd-6) is an allosteric SMAD ubiquitin regulatory factor 1 (SMURF1) inhibitor. Smurf1-IN-5 leads to a reduction in the ubiquitylation of substrates such as BMPR2 (bone morphogenetic protein receptor 2) and SMAD1, enhancing the BMP (bone morphogenetic protein) signaling pathway. Smurf1-IN-5 is promising for research of pulmonary arterial hypertension (PAH)[1].

Molecular Weight

480.92

Formula

C25H22ClFN4O3
CAS No.
SMILES

FC1=CC=CC=C1N2C(C(NC(C3=NOC(C4=CC=C(C5CC5)C=C4Cl)=C3C)=O)=C(C)N2C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Smurf1-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Smurf1-IN-51824647-09-7E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseSMURF1BMPR2BMPPAHInhibitorinhibitorinhibit

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