2. MAPK/ERK Pathway
  3. JNK
  4. JNK-IN-11

JNK-IN-11 (compound 1) is a potent JNK inhibitor with an IC50 value of 2.2, 21.4, 1.8 µM for JNK1, JNK2, JNK3, respectively. JNK-IN-11 has the potential for the research of alzheimer and parkinson disease.

For research use only. We do not sell to patients.

JNK-IN-11 Chemical Structure

JNK-IN-11 Chemical Structure

CAS No. : 676594-38-0

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Based on 1 publication(s) in Google Scholar

JNK-IN-11 Related Antibodies

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Description

JNK-IN-11 (compound 1) is a potent JNK inhibitor with an IC50 value of 2.2, 21.4, 1.8 µM for JNK1, JNK2, JNK3, respectively. JNK-IN-11 has the potential for the research of alzheimer and parkinson disease[1].

IC50 & Target[1]

JNK1

1.8 μM (IC50)

JNK3

2.2 μM (IC50)

JNK2

21.4 μM (IC50)

In Vitro

JNK-IN-11 (compound 1) exhibits remarkable selectivity over closely related kinases p38a and Erk2. JNK-IN-11 is a Type I ATP-competitive kinase inhibitor where the critical hydrogen bond formed between the inhibitor carbonyl and the NH of Met-149. The thiophene ring of the inhibitor is found to be within hydrophobic contact of the gatekeeper Met-146 side chain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNK-IN-11 Related Antibodies
Molecular Weight

281.35

Formula

C12H11NO3S2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(C1=C(NC(CC2=CC=CS2)=O)C=CS1)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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JNK-IN-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK-IN-11676594-38-0JNKc-Jun N-terminal kinasealzheimerparkinsonthiophene,Inhibitorinhibitorinhibit

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